Patents by Inventor Christopher M. Gaylo
Christopher M. Gaylo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7875290Abstract: A drug delivery device such as an oral dosage form (ODF) with a toxic or potent core encapsulated by a non-toxic region. The non-toxic region may be a region including multiple layers, coatings, shells, and combinations thereof, which provides protection to and isolation from the toxic or potent core. The drug in the toxic or potent core is incorporated into the dosage form via, for example, three-dimensional printing, as a solution, solubilization or suspension of solid particles in liquid, rather than by the more conventional handling and compressing of dry powder. This minimizes the likelihood of creating airborne particles of the toxic drug during manufacturing, hence controlling and minimizing the exposure of manufacturing personnel to the hazardous substance. Wet dispensing of the toxic or potent drug further provides greater bioavailability of the drug to the patient.Type: GrantFiled: October 7, 2005Date of Patent: January 25, 2011Assignee: Massachusetts Institute of TechnologyInventors: Francis C. Payumo, Jill K. Sherwood, Donald C. Monkhouse, Jaedeok Yoo, Christopher M. Gaylo, Chen-Chao Wang, Michael J. Cima
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Patent number: 7445441Abstract: The invention includes a three-dimensional printing (3DP) machine that has at least one ultraviolet (UV) light source directed at powder or slurry being processed by the 3DP machine and/or directed at any of various surfaces or machine components, in a manner suitable to kill or damage microorganisms to a desired extent. The UV light sources may be either stationary or movable, and may be either pulsed or substantially continuous, and may operate in any desired sequence and timing with respect to other operations performed by the machine. The invention may include ultraviolet illumination in such a way as to interact with powder to sterilize or disinfect powder either while the powder is stationary or, alternatively, as powder is being moved from one place to another within the 3DP machine, or both. The invention also includes methods of performing three-dimensional printing using such illumination.Type: GrantFiled: July 14, 2004Date of Patent: November 4, 2008Assignee: Therics, LLCInventors: Thomas George West, Qing Liu, Peter A. Materna, Alfred Anthony Litwak, Christopher M. Gaylo
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Patent number: 7276252Abstract: A drug delivery device such as an oral dosage form (ODF) with a toxic or potent core encapsulated by a non-toxic region. The non-toxic region may be a region including multiple layers, coatings, shells, and combinations thereof, which provides protection to and isolation from the toxic or potent core. The drug in the toxic or potent core is incorporated into the dosage form via, for example, three-dimensional printing, as a solution, solubilization or suspension of solid particles in liquid, rather than by the more conventional handling and compressing of dry powder. This minimizes the likelihood of creating airborne particles of the toxic drug during manufacturing, hence controlling and minimizing the exposure of manufacturing personnel to the hazardous substance. Wet dispensing of the toxic or potent drug further provides greater bioavailability of the drug to the patient.Type: GrantFiled: May 18, 2001Date of Patent: October 2, 2007Assignee: Massachusetts Institute of TechnologyInventors: Francis C. Payumo, Jill K. Sherwood, Donald C. Monkhouse, Jaedeok Yoo, Christopher M. Gaylo, Chen-Chao Wang, Michael J. Cima
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Patent number: 7122057Abstract: An engineered regenerative biostructure (erb) for implantation into a human body as a bone substitute, which includes an internal microstructure, mesostructure and/or macrostructure to provide improved bone in-growth, and methods for making the erb. Under one aspect of the invention, the biostructure has resorbable and nonresorbable regions. Under another aspect of the invention, the biostructure is constructed of hydroxyapatite, tricalcium phosphate and/or demineralized bone. Under yet another aspect of the invention, the porous biostructure is partially or fully infused with a resorbable, nonresorbable or dissolvable material.Type: GrantFiled: April 12, 2002Date of Patent: October 17, 2006Assignee: Therics, LLCInventors: Heather Ann Beam, Thomas J. Bradbury, Kathleen D. Chesmel, Christopher M. Gaylo, Alfred Anthony Litwak, Qing Liu, Peter Albert Materna, Donald Monkhouse, Jennifer Patterson, Timothy J. Pryor, Sunil Saini, Henry Leon Surprenant, Chen-Chao Wang, Thomas George West, Jaedeok Yoo
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Patent number: 7073442Abstract: Apparatus, systems and methods for use in three-dimensional printing are shown and described. Various embodiments of the invention allow for more precise and controlled delivery of heat to achieve interlayer drying; isolation of the working region from the outside for reasons of cleanliness and in connection with the vapors of organic solvents; better control of the temperature of the working region; better accuracy in the flowrates of binder fluid dispensed; matching of delivered flowrates for multiple dispensers; verification of delivered flowrate or drops; provision for easier changeover of the machine from one powder to another; cleanability; and other needs.Type: GrantFiled: July 3, 2002Date of Patent: July 11, 2006Assignee: AFBS, Inc.Inventors: Jeffrey A. Fedor, Christopher M. Gaylo, Peter A. Materna
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Patent number: 7027887Abstract: Apparatus, systems and methods for use in three-dimensional printing are shown and described. Various embodiments of the invention allow for more precise and controlled delivery of heat to achieve interlayer drying; isolation of the working region from the outside for reasons of cleanliness and in connection with the vapors of organic solvents; better control of the temperature of the working region; better accuracy in the flowrates of binder fluid dispensed; matching of delivered flowrates for multiple dispensers; verification of delivered flowrate or drops; provision for easier changeover of the machine from one powder to another; cleanability; and other needs.Type: GrantFiled: July 3, 2002Date of Patent: April 11, 2006Assignee: Theries, LLCInventors: Christopher M. Gaylo, Timothy J. Pryor, James A. Fairweather, Douglas E. Weitzel
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Patent number: 6986654Abstract: Apparatus, systems and methods for use in three-dimensional printing are shown and described. Various embodiments of the invention allow for more precise and controlled delivery of heat to achieve interlayer drying; isolation of the working region from the outside for reasons of cleanliness and in connection with the vapors of organic solvents; better control of the temperature of the working region; better accuracy in the flowrates of binder fluid dispensed; matching of delivered flowrates for multiple dispensers; verification of delivered flowrate or drops; provision for easier changeover of the machine from one powder to another; cleanability; and other needs.Type: GrantFiled: July 3, 2002Date of Patent: January 17, 2006Inventors: Ireneusz J. Imiolek, Christopher M. Gaylo
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System and method for rapidly customizing design, manufacture and/or selection of biomedical devices
Publication number: 20040243481Abstract: The rapid design and manufacture of biomedical devices such as implants, oral dosage pills and implantable pharmaceuticals employs electronic data and modeling transmissions via a computer network. Patient information and patient-specific radiological data is captured and transmitted via a computer network to a design and/or manufacturing site. A multi-dimensional digital model is created based on the radiological data and patient information. Communications interchanges between a clinical/diagnostic site and a design/manufacturing site permit modification of the digital model until approved. The approved digital model is converted into machine instructions to construct the biomedical device. Alternatively, the digital model is employed in a best fit selection of a biomedical device from a pre-existing set of biomedical devices or machine-instructions. Transmittal of data over computer networks is further directed to the use of a Website to perform various client-interaction and follow-up tasks.Type: ApplicationFiled: July 1, 2004Publication date: December 2, 2004Applicant: Therics, Inc.Inventors: Thomas J. Bradbury, Christopher M. Gaylo, James A. Fairweather, Kathleen D. Chesmel, Peter A. Materna, Adolphe Youssef -
System and method for rapidly customizing design, manufacture and/or selection of biomedical devices
Patent number: 6772026Abstract: The rapid design and manufacture of biomedical devices such as implants, oral dosage pills and implantable pharmaceuticals employs electronic data and modeling transmissions via a computer network. Patient information and patient-specific radiological data is captured and transmitted via a computer network to a design and/or manufacturing site. A multi-dimensional digital model is created based on the radiological data and patient information. Communications interchanges between a clinical/diagnostic site and a design/manufacturing site permit modification of the digital model until approved. The approved digital model is converted into machine instructions to construct the biomedical device. Alternatively, the digital model is employed in a best fit selection of a biomedical device from a pre-existing set of biomedical devices or machine-instructions. Transmittal of data over computer networks is further directed to the use of a Website to perform various client-interaction and follow-up tasks.Type: GrantFiled: October 5, 2001Date of Patent: August 3, 2004Assignee: Therics, Inc.Inventors: Thomas J. Bradbury, Christopher M. Gaylo, James A. Fairweather, Kathleen D. Chesmel, Peter A. Materna, Adolphe Youssef -
Publication number: 20040118309Abstract: Apparatus, systems and methods for use in three-dimensional printing are shown and described. Various embodiments of the invention allow for more precise and controlled delivery of heat to achieve interlayer drying; isolation of the working region from the outside for reasons of cleanliness and in connection with the vapors of organic solvents; better control of the temperature of the working region; better accuracy in the flowrates of binder fluid dispensed; matching of delivered flowrates for multiple dispensers; verification of delivered flowrate or drops; provision for easier changeover of the machine from one powder to another; cleanability; and other needs.Type: ApplicationFiled: July 3, 2002Publication date: June 24, 2004Applicant: Therics, Inc.Inventors: Jeffrey A. Fedor, Christopher M. Gaylo, Peter A. Materna
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Publication number: 20040091516Abstract: The invention includes dispensing a suspension containing solid particles for use in manufacturing a dosage form or other biomedical article by 3DP. The suspension contains solid particles suspended in a liquid. The solid particles may be one or more Active Pharmaceutical Ingredients. The solid particles may be particles of material that are insoluble in the liquid, or they may be particles of a substance that have already dissolved in the liquid up to the saturation level and are present in a concentration beyond what can be dissolved. In addition to solid particles, the liquid may also contain other substances dissolved in it, either substances containing Active Pharmaceutical Ingredients (API) or substances without API. One aspect of the invention includes prevention of agglomeration by adding one or more of several categories of additives to the suspending liquid.Type: ApplicationFiled: November 3, 2003Publication date: May 13, 2004Applicants: Therics, Inc., Massachusetts Institute of TechnologyInventors: Charles William Rowe, Wendy E. Pryce Lewis, Michael J. Cima, Esteban R.N. Bornancini, Jill K. Sherwood, Chen-Chao Wang, Christopher M. Gaylo, James A. Fairweather
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Publication number: 20040003738Abstract: Apparatus, systems and methods for use in three-dimensional printing are shown and described. Various embodiments of the invention allow for more precise and controlled delivery of heat to achieve interlayer drying; isolation of the working region from the outside for reasons of cleanliness and in connection with the vapors of organic solvents; better control of the temperature of the working region; better accuracy in the flowrates of binder fluid dispensed; matching of delivered flowrates for multiple dispensers; verification of delivered flowrate or drops; provision for easier changeover of the machine from one powder to another; cleanability; and other needs.Type: ApplicationFiled: July 3, 2002Publication date: January 8, 2004Applicant: Therics, Inc.Inventors: Ireneusz J. Imiolek, Christopher M. Gaylo
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Publication number: 20040005182Abstract: Apparatus, systems and methods for use in three-dimensional printing are shown and described. Various embodiments of the invention allow for more precise and controlled delivery of heat to achieve interlayer drying; isolation of the working region from the outside for reasons of cleanliness and in connection with the vapors of organic solvents; better control of the temperature of the working region; better accuracy in the flowrates of binder fluid dispensed; matching of delivered flowrates for multiple dispensers; verification of delivered flowrate or drops; provision for easier changeover of the machine from one powder to another; cleanability; and other needs.Type: ApplicationFiled: July 3, 2002Publication date: January 8, 2004Applicant: Therics, Inc.Inventors: Christopher M. Gaylo, Timothy J. Pryor, James A. Fairweather, Douglas E. Weitzel
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Publication number: 20030114936Abstract: The devices disclosed herein are composite implantable devices having a gradient of one or more of the following: materials, macroarchitecture, microarchitecture, or mechanical properties, which can be used to select or promote attachment of specific cell types on and in the devices prior to and/or after implantation. In preferred embodiments, the implants include complex three-dimensional structure, including curved regions and saddle-shaped areas. In various embodiments, the gradient forms a transition zone in the device from a region composed of materials or having properties best suited for one type of tissue to a region composed of materials or having properties suited for a different type of tissue.Type: ApplicationFiled: July 29, 2002Publication date: June 19, 2003Applicant: Therics, Inc.Inventors: Jill K. Sherwood, Donald Monkhouse, Christopher M. Gaylo
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Publication number: 20030099708Abstract: The invention includes dispensing a suspension containing solid particles for use in manufacturing a dosage form or other biomedical article by 3DP. The suspension contains solid particles suspended in a liquid. The solid particles may be one or more Active Pharmaceutical Ingredients. The solid particles may be particles of material that are insoluble in the liquid, or they may be particles of a substance that have already dissolved in the liquid up to the saturation level and are present in a concentration beyond what can be dissolved. In addition to solid particles, the liquid may also contain other substances dissolved in it, either substances containing Active Pharmaceutical Ingredients (API) or substances without API. One aspect of the invention includes prevention of agglomeration by adding one or more of several categories of additives to the suspending liquid.Type: ApplicationFiled: November 21, 2001Publication date: May 29, 2003Applicant: Therics, IncInventors: Charles William Rowe, Wendy E. Pryce Lewis, Michael J. Cima, Esteban R.N. Bornancini, Jill K. Sherwood, Chen-Chao Wang, Christopher M. Gaylo, James A. Fairweather
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Publication number: 20030065400Abstract: An engineered regenerative biostructure (erb) for implantation into a human body as a bone substitute, which includes an internal microstructure, mesostructure and/or macrostructure to provide improved bone in-growth, and methods for making the erb. Under one aspect of the invention, the biostructure has resorbable and nonresorbable regions. Under another aspect of the invention, the biostructure is constructed of hydroxyapatite, tricalcium phosphate and/or demineralized bone. Under yet another aspect of the invention, the porous biostructure is partially or fully infused with a resorbable, nonresorbable or dissolvable material.Type: ApplicationFiled: April 12, 2002Publication date: April 3, 2003Inventors: Heather Ann Beam, Thomas J. Bradbury, Kathleen D. Chesmel, Christopher M. Gaylo, Alfred Anthony Litwak, Qing Liu, Peter Albert Materna, Donald Monkhouse, Jennifer Patterson, Timothy J. Pryor, Sunil Saini, Henry Leon Surprenant, Chen-Chao Wang, Thomas George West, Jaedeok Yoo
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System and method for rapidly customizing design, manufacture and/or selection of biomedical devices
Publication number: 20020059049Abstract: The rapid design and manufacture of biomedical devices such as implants, oral dosage pills and implantable pharmaceuticals employs electronic data and modeling transmissions via a computer network. Patient information and patient-specific radiological data is captured and transmitted via a computer network to a design and/or manufacturing site. A multi-dimensional digital model is created based on the radiological data and patient information. Communications interchanges between a clinical/diagnostic site and a design/manufacturing site permit modification of the digital model until approved. The approved digital model is converted into machine instructions to construct the biomedical device. Alternatively, the digital model is employed in a best fit selection of a biomedical device from a pre-existing set of biomedical devices or machine-instructions. Transmittal of data over computer networks is further directed to the use of a Website to perform various client-interaction and follow-up tasks.Type: ApplicationFiled: October 5, 2001Publication date: May 16, 2002Applicant: Therics, IncInventors: Thomas J. Bradbury, Christopher M. Gaylo, James A. Fairweather, Kathleen D. Chesmel, Peter A Materna, Adolphe Youssef -
Publication number: 20020015728Abstract: A drug delivery device such as an oral dosage form (ODF) with a toxic or potent core encapsulated by a non-toxic region. The non-toxic region may be a region including multiple layers, coatings, shells, and combinations thereof, which provides protection to and isolation from the toxic or potent core. The drug in the toxic or potent core is incorporated into the dosage form via, for example, three-dimensional printing, as a solution, solubilization or suspension of solid particles in liquid, rather than by the more conventional handling and compressing of dry powder. This minimizes the likelihood of creating airborne particles of the toxic drug during manufacturing, hence controlling and minimizing the exposure of manufacturing personnel to the hazardous substance. Wet dispensing of the toxic or potent drug further provides greater bioavailability of the drug to the patient.Type: ApplicationFiled: May 18, 2001Publication date: February 7, 2002Inventors: Francis C. Payumo, Jill K. Sherwood, Donald C. Monkhouse, Jaedeok Yoo, Christopher M. Gaylo, Chen-Chao Wang, Michael J. Cima
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Patent number: 6341952Abstract: A system for molding a tissue or substitute tissue product in a mold having an exterior surface, and an interior surface, wherein at least one portion of the interior surface is porous and whose pores are in continuous communication with the exterior surface, and wherein said mold can be fabricated using solid free-form fabrication techniques is disclosed.Type: GrantFiled: January 22, 2001Date of Patent: January 29, 2002Assignee: Therics, Inc.Inventors: Christopher M. Gaylo, Walter Flamenbaum, Miles J. Flamenbaum
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Publication number: 20020007294Abstract: A method of rapid design and manufacture of biomedical devices using electronic data and modeling transmissions, wherein such transmissions are transferred via a computer network. The method includes capturing patient-specific diagnostic imaged data, converting the data to a digital computer file, transmitting the converted data via the computer network to a remote manufacturing site, converting the computer file into a multi-dimensional model and then into machine instructions, and constructing the biomedical implant. The present invention is further directed to the preparation of rapid-prototyped pharmaceutical forms, including oral dosage pills and implantable pharmaceuticals, with transmittal of such data over computer networks being used to significantly increase the cost effectiveness and responsiveness, and is further directed to the use of a website to perform various client-interaction and follow-up tasks.Type: ApplicationFiled: April 5, 2001Publication date: January 17, 2002Inventors: Thomas J. Bradbury, Christopher M. Gaylo, James A. Fairweather, Kathleen D. Chesmel, Peter A. Materna