Patents by Inventor Christopher M. Mapes

Christopher M. Mapes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor
    Patent number: 9365548
    Abstract: Benzoimidazol-2-yl pyrimidines and pyrazines, pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritis.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: June 14, 2016
    Assignee: Janssen Pharmaceutica NV
    Inventors: James P. Edwards, David E. Kindrachuk, Christopher M. Mapes, Daniel J. Pippel, Jennifer D. Venable
  • Process for the preparation of substituted pyrimidine derivatives
    Patent number: 9359327
    Abstract: The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: June 7, 2016
    Assignee: Janssen Pharmaceutica NV
    Inventors: Sergio Cesco-Cancian, Hongfeng Chen, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Kirk L. Sorgi, Tong Xiao
  • Process for the preparation of substituted pyrimidine derivatives
    Patent number: 9079884
    Abstract: The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
    Type: Grant
    Filed: November 11, 2013
    Date of Patent: July 14, 2015
    Assignee: Janssen Pharmaceutica NV
    Inventors: Sergio Cesco-Cancian, Hongfeng Chen, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Kirk L. Sorgi, Tong Xiao
  • Process for the preparation of substituted pyrimidine derivatives
    Patent number: 9079882
    Abstract: The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: July 14, 2015
    Assignee: Janssen Pharmaceutica NV
    Inventors: Sergio Cesco-Cancian, Hongfeng Chen, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Kirk L. Sorgi, Tong Xiao
  • Process for the preparation of substituted pyrimidine derivatives
    Patent number: 9079883
    Abstract: The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 14, 2015
    Assignee: Janssen Pharmaceutica NV
    Inventors: Sergio Cesco-Cancian, Hongfeng Chen, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Kirk L. Sorgi, Tong Xiao
  • Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor
    Publication number: 20150148361
    Abstract: Benzoimidazol-2-yl pyrimidines and pyrazines, pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritis.
    Type: Application
    Filed: January 28, 2015
    Publication date: May 28, 2015
    Inventors: James P. Edwards, David E. Kindrachuk, Christopher M. Mapes, Daniel J. Pippel, Jennifer D. Venable
  • Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine Hreceptor
    Patent number: 8962644
    Abstract: Benzoimidazol-2-yl pyrimidines and pyrazines, pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritis.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: February 24, 2015
    Assignee: Janssen Pharmaceutica, NV
    Inventors: James P. Edwards, David E. Kindrachuk, Christopher M. Mapes, Daniel J. Pippel, Jennifer D. Venable
  • Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives
    Patent number: 8921550
    Abstract: The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: December 30, 2014
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Neelakandha S. Mani, Christopher M. Mapes, Daniel J. Pippel, Diego F. Broggini
  • Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives
    Patent number: 8835633
    Abstract: The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: September 16, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Sergio Cesco-Cancian, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Tong Xiao, Diego Broggini, Susanne Lochner
  • Process for the preparation of substituted pyrimidine derivatives
    Publication number: 20140073795
    Abstract: The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
    Type: Application
    Filed: November 13, 2013
    Publication date: March 13, 2014
    Applicant: Janssen Pharmaceutica NV
    Inventors: Sergio Cesco-Cancian, Hongfeng Chen, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Kirk L. Sorgi, Tong Xiao
  • Process for the preparation of substituted pyrimidine derivatives
    Publication number: 20140066624
    Abstract: The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
    Type: Application
    Filed: November 11, 2013
    Publication date: March 6, 2014
    Applicant: Janssen Pharmaceutica NV
    Inventors: Sergio Cesco-Cancian, Hongfeng Chen, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Kirk L. Sorgi, Tong Xiao
  • Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor
    Publication number: 20140038995
    Abstract: Benzoimidazol-2-yl pyrimidines and pyrazines, pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritis.
    Type: Application
    Filed: October 11, 2013
    Publication date: February 6, 2014
    Applicant: Janssen Pharmaceutica NV
    Inventors: James P. Edwards, David E. Kindrachuk, Christopher M. Mapes, Daniel J. Pippel, Jennifer D. Venable
  • Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine Hreceptor
    Patent number: 8598189
    Abstract: Benzoimidazol-2-yl pyrimidines and pyrazines, pharmaceutical compositions and methods for H4 receptor activity modulation and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritis.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: December 3, 2013
    Assignee: Janssen Pharmaceutica NV
    Inventors: James P. Edwards, David E. Kindrachuk, Christopher M. Mapes, Daniel J. Pippel, Jennifer D. Venable
  • Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine Hreceptor
    Patent number: 8343989
    Abstract: Benzoimidazol-2-yl pyrimidines and pyrazines, pharmaceutical compositions and methods for H4 receptor activity modulation and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritis.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: January 1, 2013
    Assignee: Janssen Pharmaceutica NV
    Inventors: James P. Edwards, David E. Kindrachuk, Christopher M. Mapes, Daniel J. Pippel, Jennifer D. Venable
  • Process for the preparation of substituted pyrimidine derivatives
    Patent number: 8309720
    Abstract: The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: November 13, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Sergio Cesco-Cancian, Hongfeng Chen, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Kirk L. Sorgi, Tong Xiao
  • Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives
    Publication number: 20120184740
    Abstract: The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
    Type: Application
    Filed: March 22, 2012
    Publication date: July 19, 2012
    Inventors: Sergio Cesco-Cancian, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Tong Xiao, Diego Broggini, Susanne Lochner
  • Process for the preparation of benzoimidazol-2-yl pyrimidine derivatgives
    Publication number: 20120178932
    Abstract: The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
    Type: Application
    Filed: March 22, 2012
    Publication date: July 12, 2012
    Inventors: Sergio CESCO-CANCIAN, Jeffrey S. GRIMM, Neelakandha S. MANI, Christopher M. MAPES, David C. PALMER, Daniel J. PIPPEL, Tong XIAO, Diego BROGGINI, Susanne LOCHNER
  • BENZOIMIDAZOL-2-YL PYRIMIDINES AND PYRAZINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR
    Publication number: 20100256373
    Abstract: Benzoimidazol-2-yl pyrimidines and pyrazines, pharmaceutical compositions and methods for H4 receptor activity modulation and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritis.
    Type: Application
    Filed: June 16, 2010
    Publication date: October 7, 2010
    Inventors: James P. EDWARDS, David E. KINDRACHUK, Christopher M. MAPES, Daniel J. PIPPEL, Jennifer D. VENABLE
  • Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives
    Publication number: 20100029942
    Abstract: The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
    Type: Application
    Filed: June 29, 2009
    Publication date: February 4, 2010
    Inventors: Sergio Cesco-Cancian, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Tong Xiao, Diego Broggini, Susanne Lochner
  • Process for the preparation of substituted pyrimidine derivatives
    Publication number: 20100004450
    Abstract: The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
    Type: Application
    Filed: June 29, 2009
    Publication date: January 7, 2010
    Inventors: Sergio Cesco-Cancian, Hongfeng Chen, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Kirk L. Sorgi, Tong Xiao