Abstract: Provided herein are compounds of formula (II): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein m, n, p, R1, R2, R3, L1, L2, L3, R4, X1, X2, X3, and X4 are as defined herein. Also provided are methods of preparing compounds of formula (II), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided are methods of inhibiting APOL1 and methods of treating an APOL1-mediated disease, disorder, or condition in an individual.

Abstract: A ground plane detection system for a motor vehicle and a motor vehicle with enhanced maneuverability characteristics of a type including a frame structure, a pair of front road engaging wheels, a pair of rear road engaging wheels. The detection system includes, a body controller configured for determining a ground plane including receiving at least one of a GPS signal and an inertial navigation system signal. The body controller is further configured for providing a roll and a pitch signal with respect to the ground plane; and the body controller combining the signals with inputs from one or more sensors detecting displacement of the front and rear road engaging wheels. The body controller is also configured to determine a terrain plane reference to the ground plane, and providing control signals to cause the vehicle to undertake an earth level orientation mode or a terrain following orientation mode.

Abstract: A ground plane detection system for a motor vehicle and a motor vehicle with enhanced maneuverability characteristics of a type including a frame structure, a pair of front road engaging wheels, a pair of rear road engaging wheels. The detection system includes, a body controller configured for determining a ground plane including receiving at least one of a GPS signal and an inertial navigation system signal. The body controller is further configured for providing a roll and a pitch signal with respect to the ground plane; and the body controller combining the signals with inputs from one or more sensors detecting displacement of the front and rear road engaging wheels. The body controller is also configured to determine a terrain plane reference to the ground plane, and providing control signals to cause the vehicle to undertake an earth level orientation mode or a terrain following orientation mode.

Abstract: An instrumentation system including a plurality of sensors attached to a test piece, each of the sensors provided with an electrical signal generating device and an electrical signal measurement device. Each sensor is located remotely from its electrical signal measurement device, and connected thereto by connectors. A method of testing connectivity of the instrumentation system including: inducing an electrical signal in a first sensor; and checking that the electric signal is received in the corresponding signal measurement device.

Abstract: A blank for forming a carton, the carton formed therefrom, and a closure for the carton are provided for enclosing a plurality of unbound elongate smoking articles. The blank includes a base sub-blank at the distal end which is folded to form an open top box and a lid sub-blank at the proximal end which is folded to form a top for the box. A movable lid sub-panel is formed in the lid sub-blank which is hingedly removable therefrom to open the top of the box and which is reclosable by use of a foldable member provided therein. After opening of the movable lid sub-panel, the foldable member is folded over to form an extending tab which is received in a weakening line provided in an underlying front panel of the carton when it is desired to hold the movable lid sub-panel in a closed position.