Abstract: Disclosed is a nickel-base alloy comprising, in weight percentages based on total alloy weight: 11 to 18 chromium; 16 to 28 cobalt; 1.5 to 7.0 molybdenum; 0 to 6.5 tungsten; 0 to 1.0 niobium; 1.0 to 2.5 aluminum; 2.0 to 6.0 titanium; 0 to 2.0 tantalum; 0 to 4.0 iron; 0 to 0.5 hafnium; 0.01 to 0.2 carbon; 0.001 to 0.02 boron; 0.001 to 0.1 zirconium; nickel; and impurities. Also disclosed is a nickel-base alloy comprising, in weight percentages based on total alloy weight: 11 to 18 chromium; 24 to 28 cobalt; 1.5 to 7.0 molybdenum; 2.0 to 6.0 tungsten; 0 to 1.0 niobium; 1.0 to 2,5 aluminum; 2,0 to 6.0 titanium; 0 to 2.0 tantalum; 0 to 4.0 iron; 0 to 0.5 hafnium; 0.01 to 0.2 carbon; 0.001 to 0.02 boron; 0.001 to 0.1 zirconium; nickel; and impurities.

Abstract: Processes and methods related to processing and hot working alloy ingots are disclosed. A metallic material layer is deposited onto at least a region of a surface of an alloy ingot before hot working the alloy ingot. The processes and methods are characterized by a reduction in the incidence of surface cracking of the alloy ingot during hot working.

Abstract: Processes and methods related to processing and hot working alloy ingots are disclosed. A metallic material layer is deposited onto at least a region of a surface of an alloy ingot before hot working the alloy ingot. The processes and methods are characterized by a reduction in the incidence of surface cracking of the alloy ingot during hot working.

Abstract: Processes and methods related to processing and hot working alloy ingots are disclosed. A metallic material layer is deposited onto at least a region of a surface of an alloy ingot before hot working the alloy ingot. The processes and methods are characterized by a reduction in the incidence of surface cracking of the alloy ingot during hot working.

Abstract: The invention describes methods for producing a biphasic nanocomposite scaffold comprising custom polymer-based core-shelled nanospheres by the physical and chemical attachment of two disparate polymeric materials whose composition can be readily modified with tissue-specific nanomaterials and products created using such methods. The custom nanospheres are constructed via co-axial wet electrospraying and can be employed to deliver compounds to the polymeric materials.

Abstract: The present invention provides for methods and compositions for treating, reducing and/or preventing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate, prodrug thereof, functional analog or a pharmaceutically effective salt thereof in an amount sufficient to increase activity of at least one kinase in heart tissue of the subject.

Abstract: The present invention provides for methods for treating and/or reducing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate, functional analogue or a pharmaceutically effective salt thereof.

Abstract: A system and method of processing an alloy ingot or other alloy workpiece to reduce thermal cracking and reduce friction between the workpiece and the forging die may generally comprise positioning a multi-layer pad between the workpiece and the forging die. An article for processing an alloy ingot or other alloy workpiece to reduce thermal cracking also is disclosed. The present disclosure also is directed to an alloy workpieces processed according to the methods described herein, and to articles of manufacture including or made from alloy workpieces made according to these methods.

Abstract: A system and method of processing an alloy ingot or other alloy workpiece to reduce thermal cracking and reduce friction between the workpiece and the forging die may generally comprise positioning a multi-layer pad between the workpiece and the forging die. An article for processing an alloy ingot or other alloy workpiece to reduce thermal cracking also is disclosed. The present disclosure also is directed to an alloy workpieces processed according to the methods described herein, and to articles of manufacture including or made from alloy workpieces made according to these methods.

Abstract: The invention describes methods for producing a biphasic nanocomposite scaffold comprising custom polymer-based core-shelled nanospheres by the physical and chemical attachment of two disparate polymeric materials whose composition can be readily modified with tissue-specific nanomaterials and products created using such methods. The custom nanospheres are constructed via co-axial wet electrospraying and can be employed to deliver compounds to the polymeric materials.

Abstract: Processes and methods related to processing and hot working alloy ingots are disclosed. A metallic material layer is deposited onto at least a region of a surface of an alloy ingot before hot working the alloy ingot. The processes and methods are characterized by a reduction in the incidence of surface cracking of the alloy ingot during hot working.

Abstract: Processes and methods related to processing and hot working alloy ingots are disclosed. A metallic material layer is deposited onto at least a region of a surface of an alloy ingot before hot working the alloy ingot. The processes and methods are characterized by a reduction in the incidence of surface cracking of the alloy ingot during hot working.

Abstract: The present invention provides for methods and compositions for treating, reducing and/or preventing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate, prodrug thereof, functional analogue or a pharmaceutically effective salt thereof in an amount sufficient to increase activity of at least one kinase in heart tissue of the subject.

Abstract: A system and method of processing an alloy ingot or other alloy workpiece to reduce thermal cracking and reduce friction between the workpiece and the forging die may generally comprise positioning a multi-layer pad between the workpiece and the forging die. An article for processing an alloy ingot or other alloy workpiece to reduce thermal cracking also is disclosed. The present disclosure also is directed to an alloy workpieces processed according to the methods described herein, and to articles of manufacture including or made from alloy workpieces made according to these methods.

Abstract: The present invention provides for methods and compositions for treating and/or preventing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate, functional analogue or a pharmaceutically effective salt thereof.

Abstract: Processes and methods related to processing and hot working alloy ingots are disclosed. A metallic material layer is deposited onto at least a region of a surface of an alloy ingot before hot working the alloy ingot. The processes and methods are characterized by a reduction in the incidence of surface cracking of the alloy ingot during hot working.

Abstract: A one-arm data center topology routes traffic between internal sub-nets and between a sub-net and an outside network through a common chain of services. The data center topology employs layer 4 services on a common chassis or platform to provide routing and firewall services while reducing the number of devices necessary to implement the data center and simplifying configuration. Load balancing is provided by a load balancing device. In the one-arm topology, policy based routing or client network address translations or NAT pushes traffic to the CSM.

Abstract: The present invention pertains to methods for reducing the platelet activation state in an individual comprising administering a selective serotonin reuptake inhibitor (SSRI). The platelet activation state is reduced upon administering a SSRI, as measured by one or more platelet activation markers. The invention also relates to methods for treating or preventing an individual at risk for a vascular event, disease or disorder by administering a SSRI.

Abstract: The present invention pertains to methods for reducing the platelet activation state in an individual comprising administering a selective serotonin reuptake inhibitor (SSRI). The platelet activation state is reduced upon administering a SSRI, as measured by one or more platelet activation markers. The invention also relates to methods for treating or preventing an individual at risk for a vascular event, disease or disorder by administering a SSRI.

Abstract: The present invention pertains to methods for reducing the platelet activation state in an individual comprising administering a selective serotonin reuptake inhibitor (SSRI). The platelet activation state is reduced upon administering a SSRI, as measured by one or more platelet activation markers. The invention also relates to methods for treating or preventing an individual at risk for a vascular event, disease or disorder by administering a SSRI.