Abstract: An audio device adapted for altering the structure of water is provided. The device includes a rigid, enclosed cabinet with speakers mounted to the cabinet. The speakers are positioned on opposing walls, facing each other, within the cavity of the cabinet and a watertight container is placed between the speakers. The exterior surface of the container rests directly against with the cone or the voice coil of the speakers, which are connected to an external sound system. Because the container is flush against the surface of the speakers, vibrations from the sound waves generated by the cone or the voice coil are transferred directly through the water. The sound waves alter the structure of the water from a liquid form to a liquid crystalline form, such that the liquid crystalline takes coherent geometric shapes.

Abstract: A breathing assistance apparatus is configured with features that improve serviceability of the apparatus. The apparatus can include animations to provide instruction regarding correcting easily-identified fault conditions and to provide instruction regarding routine maintenance routines. The apparatus also can be configured with top level control menus that are obscured in a manner to limit manipulation of the top level control elements by unauthorized users.

Abstract: One embodiment relates to a tilt-imaging scanning electron microscope apparatus. The apparatus includes an electron gun, first and second deflectors, an objective electron lens, and a secondary electron detector. The first deflector deflects the electron beam away from the optical axis, and the second deflector deflects the electron beam back towards the optical axis. The objective lens focuses the electron beam onto a spot on a surface of a target substrate, wherein the electron beam lands on the surface at a tilt angle. Another embodiment relates to a method of imaging a surface of a target substrate using an electron beam with a trajectory tilted relative to a substrate surface. Other embodiments and features are also disclosed.

Abstract: A detonator which includes a tubular body within which is located a detonator assembly which comprise a container (20) which houses a set explosive composition element in which is embedded part of a PCB (72, 76) which carries an ignition element (66).

Abstract: The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.

Abstract: A detonator assembly (10) which includes a housing (16), an explosive (20) in the housing (16), an initiating element (32) exposed to the explosive (20), a circuit for controlling operation of the initiating element (32), and a communication arrangement which can establish communication between the circuit and an external controller (60) at least at one optical frequency.

Abstract: Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.

Abstract: A detonator (120) which has a battery (136) which is movable by a pressure wave from a shock tube (158) to a position at which the battery is placed in electrical contact with a circuit (130) which controls firing of an ignition element (128).

Abstract: Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.

Abstract: A breathing assistance system is provided for delivering a flow of gases to a user. The system includes a humidifier unit which holds and heats a volume of water, and which in use receives a flow of gases from a gases source via an inlet port. The flow of gases passes through the humidifier and exits via an exit port. The system further having a temperature sensor which measures the temperature of the gases exiting the humidifier unit, an ambient temperature sensor which measures the temperature of gases before they enter the humidifier unit, and a flow sensor which measures the flow rate of the gases stream. The system also has a controller which receives data from the temperature and flow sensors, and which determines a control output in response. The control output is configured to adjust the power to the humidifier unit to achieve a desired output at the humidifier unit exit port.

Abstract: The present invention relates to methods for diagnosing transplant rejection, or a condition associated with transplant rejection, such as, primary graft dysfunction in a subject, to antigen probe arrays for performing such a diagnosis, and to antigen probe sets for generating such arrays.

Abstract: A detonator which has a printed circuit board with contact pads which are electrically connected to conductors by means of a compression-type fitting.

Abstract: One embodiment disclosed relates to an electron source for generating an electron beam. The electron source includes an electron emitter having a tip from which an electron beam is extracted. The electron further includes a non-planar extractor with an extractor opening and a built-in beam-limiting aperture. The extractor opening is larger than the beam-limiting aperture, and central axes of both the extractor opening and the beam-limiting aperture are aligned with the tip along a beam axis. Another embodiment relates to a method of generating an electron beam using an electron source having a non-planar extractor. Another embodiment relates to an array of electron sources for generating an array of electron beams. The array of electron sources includes an array of electron emitters and an array of non-planar extractor structures. Other embodiments, aspects and features are also disclosed.

Abstract: One embodiment disclosed relates an apparatus which includes an electromagnet arranged to provide a large-scale magnetic field in a region. The apparatus further includes an array of multiple electron beam columns formed in the region using an array of bores through magnetic material. Another embodiment relates to a method of generating an array of electron beams. A large-scale magnetic field is generated in a region using at least two magnetic poles. The array of electron beams is generated using an array of columns formed using bores through a magnetic material positioned in the region. Other embodiments, aspects and features are also disclosed.

Abstract: One embodiment disclosed relates an apparatus which includes an electromagnet arranged to provide a large-scale magnetic field in a region. The apparatus further includes an array of multiple electron beam columns formed in the region using an array of bores through magnetic material. Another embodiment relates to a method of generating an array of electron beams. A large-scale magnetic field is generated in a region using at least two magnetic poles. The array of electron beams is generated using an array of columns formed using bores through a magnetic material positioned in the region. Other embodiments, aspects and features are also disclosed.

Abstract: A detonator (120) which has a battery (136) which is movable by a pressure wave from a shock tube (158) to a position at which the battery is placed in electrical contact with a circuit (130) which controls firing of an ignition element (128).

Abstract: A breathing assistance system for delivering a stream of heated, humidified gases to a user, comprising a humidifier unit which holds and heats a volume of water, and which in use receives a flow of gases from a gases source via an inlet port, the flow of gases passing through the humidifier and exiting via an exit port, the system further having a temperature sensor which measures the temperature of the gases exiting the humidifier unit, an ambient temperature sensor which measures the temperature of gases before they enter the humidifier unit, and a flow sensor which measures the flow rate of the gases stream, the system also having a controller which receives data from the temperature and flow sensors, and which determines a control output in response, the control output adjusting the power to the humidifier unit to achieve a desired output at the humidifier unit exit port.

Abstract: A timing module for use in a detonating system which includes discriminating and validating arrangements which sense and validate at least one characteristic of at least one parameter produced by at least one shock tube event and an electronic timer which executes a timing interval in response thereto.

Abstract: The invention relates to novel tetralone based amines and their use in the treatment of central nervous system (CNS) disorders, such as depression, attention deficit hyperactivity disorder (ADHD) and Parkinson's disease. The invention further relates to pharmaceutical compositions containing the compounds and compositions of the invention as well as methods of inhibiting reuptake of one or more monoamine, such as such as dopamine and norepinephrine, from the synaptic cleft, and methods of modulating one or more monoamine transporter.

Abstract: A method of crosslinking a protein or peptide for use as a biomaterial, the method comprising the step of irradiating a photoactivatable metal-ligand complex and an electron acceptor in the presence of the protein or peptide, thereby initiating a crosslinking reaction to form a 3-dimensional matrix of the biomaterial.