Patents by Inventor Christopher McLean

Christopher McLean has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200078350
    Abstract: Provided are compositions and methods comprising a FOXO inhibitor for increasing proliferation of Lgr5+ cochlear cells, and related methods of treating hearing loss.
    Type: Application
    Filed: August 19, 2019
    Publication date: March 12, 2020
    Inventors: Christopher LOOSE, Will MCLEAN, Megan HARRISON, Melissa HILL-DRZEWI
  • Publication number: 20200080054
    Abstract: Provided are compositions and methods comprising Jag-1 agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
    Type: Application
    Filed: August 19, 2019
    Publication date: March 12, 2020
    Inventors: Christopher Loose, Will McLean, Megan Harrison
  • Publication number: 20200080055
    Abstract: Provided are compositions and methods comprising PI3K agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
    Type: Application
    Filed: August 19, 2019
    Publication date: March 12, 2020
    Inventors: Christopher LOOSE, Will MCLEAN, Megan HARRISON
  • Patent number: 10530088
    Abstract: A stage pin electrical connector includes a housing having a first housing member and a second housing member. The first and second housing members are releasably connected together to define an interior, a conductor opening, a contact portion, and a contact opening. The contact portion includes a first snap-fit connection feature. A sleeve receives a contact member and has a second snap-fit connection feature configured to releasably mate with the first snap-fit connection feature.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: January 7, 2020
    Assignee: Hubbell Incorporated
    Inventors: Ryan Papageorge, Thomas Scanzillo, Christopher Carbone, Tom McLean
  • Publication number: 20190352313
    Abstract: The present invention relates to 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.
    Type: Application
    Filed: December 21, 2017
    Publication date: November 21, 2019
    Inventors: Christopher LOOSE, Bradley TAIT, Rajesh MANCHANDA, Will MCLEAN
  • Patent number: 10416342
    Abstract: The invention provides a device (100) for screening one or more items (101,1806) of freight or baggage for one or more types of target material, the device comprising: a source (200, 201,1800) of incident radiation (204,206,1804) configured to irradiate the one or more items (101,1806); a plurality of detectors (202,209,1807, 301) adapted to detect packets of radiation (205,207,1700) emanating from within or passing through the one or more items (101, 1806) as a result of the irradiation by the incident radiation (204, 206, 1804), each detector being configured to produce an electrical pulse (312) caused by the detected packets having a characteristic size or shape dependent on an energy of the packets; one or more digital processors (203, 210, 303, 304, 306, 305) configured to process each electrical pulse to determine the characteristic size or shape and to thereby generate a detector energy spectrum for each detector of the energies of the packets detected, and characterize a material associated with the o
    Type: Grant
    Filed: November 28, 2015
    Date of Patent: September 17, 2019
    Assignee: Southern Innovation International Pty Ltd
    Inventors: Paul Scoullar, Christopher McLean, Shane Tonissen, Syed Khusro Saleem, Brendan Allman
  • Patent number: 10383881
    Abstract: The present invention relates to 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: August 20, 2019
    Assignee: Frequency Therapeutics, Inc.
    Inventors: Christopher Loose, Bradley Tait, Rajesh Manchanda, Will McLean
  • Patent number: 10368685
    Abstract: An infusion extractor is provided including a plunger to be inserted into an infusing container containing the infusion mixture that has vertical inner walls oriented parallel to a vertical axis of the container. The plunger includes a first surface with a seal situated at an edge of the surface. The seal is adapted for sealing against the inner walls of the infusing container as the plunger moves within the container, to define a first chamber containing the mixture of infusible material and extract. The plunger also includes a second surface extending from the first surface and defining a second chamber; the second surface includes extract flow openings which permit flow of extract from the first chamber into the second chamber. At least a portion of the extract flow openings are situated at a depth either above or below the first surface along the vertical axis.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: August 6, 2019
    Assignee: Espro Inc.
    Inventors: Christopher McLean, Bruce A. Constantine
  • Publication number: 20190231880
    Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Application
    Filed: January 4, 2019
    Publication date: August 1, 2019
    Inventors: Christopher LOOSE, Will MCLEAN, Megan HARRISON, Michael R. JIROUSEK
  • Publication number: 20190212272
    Abstract: The invention provides a material characterisation system and method for characterising a stream of material emanating from a material identification, exploration, extraction or processing activity, the system comprising: a source of incident radiation (64) configured to irradiate the stream of material in an irradiation region (18); one or more detectors (300,302,312,1701,1704,1600,1607,1608,1604) adapted to detect radiation emanating from within or passing through the stream of material as a result of the irradiation by the incident radiation (1700) and thereby produce a detection signal (313); and one or more digital processors (304-311,2000-2009) configured to process the detection signal to characterise the stream of material; wherein the source of incident radiation (64) and the one or more detectors (300,302,312,1701,1704,1600,1607,1608,1604) are adapted to be disposed relative to the stream of material so as to irradiate the stream of material and detect the radiation emanating from within or passing
    Type: Application
    Filed: May 30, 2017
    Publication date: July 11, 2019
    Inventors: Paul SCOULLAR, Christopher MCLEAN, Shane TONISSEN, Syed Khusro SALEEM
  • Publication number: 20190212273
    Abstract: The invention provides a system and method for characterising at least part of a material comprising: a source of incident X-rays (4, 28) configured to irradiate at least part of the material; one or more detectors (300,302,312,1701,1704,1600,1607,1608,1604) adapted to detect radiation emanating from within or passing through the material as a result of the irradiation by the incident radiation (1700) and thereby produce a detection signal (313); and one or more digital processors (304-311,2000-2009) configured to process the detection signal (313) to characterise at least part of the material; wherein the one or more detectors (300,302,312,1701, 1704,1600,1607,1608,1604) and one or more digital processors (304-311,2000-2009) are configured to characterise at least part of the material by performing energy resolved photon counting X-ray transmission spectroscopy analysis.
    Type: Application
    Filed: May 30, 2017
    Publication date: July 11, 2019
    Inventors: Paul SCOULLAR, Christopher MCLEAN, Shane TONISSEN, Syed SALEEM
  • Publication number: 20190201398
    Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Application
    Filed: December 20, 2018
    Publication date: July 4, 2019
    Inventors: Christopher LOOSE, Will MCLEAN, Megan HARRISON, Michael R. JIROUSEK
  • Publication number: 20170269257
    Abstract: The invention provides a device (100) for screening one or more items (101,1806) of freight or baggage for one or more types of target material, the device comprising: a source (200, 201,1800) of incident radiation (204,206,1804) configured to irradiate the one or more items (101,1806); a plurality of detectors (202,209,1807, 301) adapted to detect packets of radiation (205,207,1700) emanating from within or passing through the one or more items (101, 1806) as a result of the irradiation by the incident radiation (204, 206, 1804), each detector being configured to produce an electrical pulse (312) caused by the detected packets having a characteristic size or shape dependent on an energy of the packets; one or more digital processors (203, 210, 303, 304, 306, 305) configured to process each electrical pulse to determine the characteristic size or shape and to thereby generate a detector energy spectrum for each detector of the energies of the packets detected, and characterise a material associated with the o
    Type: Application
    Filed: November 28, 2015
    Publication date: September 21, 2017
    Inventors: Paul SCOULLAR, Christopher MCLEAN, Shane TONISSEN, Syed Khusro SALEEM, Brendan ALLMAN
  • Publication number: 20170027372
    Abstract: An infusion extractor is provided including a plunger to be inserted into an infusing container containing the infusion mixture that has vertical inner walls oriented parallel to a vertical axis of the container. The plunger includes a first surface with a seal situated at an edge of the surface. The seal is adapted for sealing against the inner walls of the infusing container as the plunger moves within the container, to define a first chamber containing the mixture of infusible material and extract. The plunger also includes a second surface extending from the first surface and defining a second chamber; the second surface includes extract flow openings which permit flow of extract from the first chamber into the second chamber. At least a portion of the extract flow openings are situated at a depth either above or below the first surface along the vertical axis.
    Type: Application
    Filed: August 3, 2016
    Publication date: February 2, 2017
    Inventors: Christopher McLean, Bruce A. Constantine
  • Publication number: 20160352861
    Abstract: Techniques for administering member profiles on a social networking web site. In some embodiments, for example, a computer-implemented method comprises: sending a browser cookie to a computing device of an authenticated user containing information representing at least one administrative privilege the authenticated user has on a social networking web site; receiving a request for a profile page of a member of a social network from the authenticated user; determining, based on the browser cookie, if the request is made with the at least one administrative privilege; and if so, causing at least a portion of the profile page of the member to be displayed to the authenticated user with a visual indication on the portion of the profile page that the authenticated user currently has the at least one administrative privilege with respect to the member's profile page.
    Type: Application
    Filed: May 30, 2015
    Publication date: December 1, 2016
    Inventors: Christopher T. White, Christopher McLean, Arvind Mani, Madhushree Gupta, Rastan Boroujerdi
  • Patent number: 7992486
    Abstract: An espresso tamper including a force calibration means is shown. The tamper is optimally handheld. Upon force of a desired magnitude being applied by a user, at least one discrete signal, such as an audible, visual, tactile or electrical signal is emitted. The tamper handle includes an anti-rotation feature. The handle is flared to avoid pinching the user's fingers during operation and to stop the user's fingers from sliding down the handle or in any way touching the base, thereby rendering the tamper more effective and safe. The tamper and force-calibration kit and method of use optimize espresso making.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: August 9, 2011
    Assignee: Espro Inc.
    Inventors: Bruce Constantine, Christopher McLean
  • Publication number: 20070187421
    Abstract: A steaming pitcher comprising a flow receiving surface adapted to receive an incoming flow of steam at a substantially oblique angle provides enhanced control of fluid flow inside the steaming pitcher to enhance mixing and heating of the fluid by the incoming steam. The steaming pitcher may also comprise flow directing and launching surfaces to assist in control of fluid flow patterns. A flow control kit with a flow receiving surface may be installed in an existing flat-bottom steaming pitcher to provide aspects of fluid flow control. The flow receiving, flow directing and launching surfaces of the steaming pitcher may be substantially smooth, faceted, or a combination thereof.
    Type: Application
    Filed: February 13, 2007
    Publication date: August 16, 2007
    Applicant: Espro Inc.
    Inventors: Bruce Constantine, Christopher McLean
  • Publication number: 20060257708
    Abstract: An electrical generating system consists of a fuel cell, and an oxygen gas delivery. The fuel cell includes and anode channel having an anode gas inlet for receiving a supply of hydrogen gas, a cathode channel having a cathode gas inlet and a cathode gas outlet, and an electrolyte in communication with the anode and cathode channel for facilitating ion exchange between the anode and cathode channel. The oxygen gas delivery system is coupled to the cathode gas inlet and delivers oxygen gas to the cathode channel. The electrical current generating system also includes gas recirculation means couple to the cathode gas outlet for recirculating a portion of cathode exhaust gas exhausted from the cathode gas outlet to the cathode gas inlet.
    Type: Application
    Filed: July 21, 2006
    Publication date: November 16, 2006
    Inventors: Bowie Keefer, Christopher McLean, Michael Brown
  • Publication number: 20050183572
    Abstract: Gas separation by pressure swing adsorption (PSA) and vacuum pressure swing adsorption (VPSA), to obtain a purified product gas of the less strongly adsorbed fraction of the feed gas mixture, is performed with an apparatus having a plurality of adsorbers. The adsorbers cooperate with first and second valves in a rotary PSA module, with the PSA cycle characterized by multiple intermediate pressure levels between the higher and lower pressures of the PSA cycle. Gas flows enter or exit the PSA module at the intermediate pressure levels as well as the higher and lower pressure levels, under substantially steady conditions of flow and pressure. The PSA module may comprise a rotor containing laminated sheet adsorbers and rotating within a stator, with ported valve faces between the rotor and stator to control the timing of the flows entering or exiting the adsorbers in the rotor.
    Type: Application
    Filed: July 2, 2004
    Publication date: August 25, 2005
    Inventors: Bowie Keefer, Christopher McLean, Matthew Babicki
  • Publication number: 20050145111
    Abstract: A rotary module for implementing a high frequency pressure swing adsorption process comprises a stator and a rotor rotatably coupled to the stator. The stator includes a first stator valve surface, a second stator valve surface, a plurality of first function compartments opening into the first stator valve surface, and a plurality of second function compartments opening into the second stator valve surface. The rotor includes a first rotor valve surface in communication with the first stator valve surface, a second rotor valve surface in communication with the second stator valve surface, and a plurality of flow paths for receiving adsorbent material therein.
    Type: Application
    Filed: July 14, 2003
    Publication date: July 7, 2005
    Inventors: Bowie Keefer, David Doman, Christopher McLean