Abstract: Spray-dried thrombin materials obtained from feedstock solutions comprising less than 5% by weight albumin and excluding trehalose or other excipients as well as methods of manufacturing the thrombin materials and methods of treating bleeding wounds are disclosed. The methods of use include applying reconstituted spray-dried thrombin topically to a bleeding site, optionally in conjunction with gelatin.

Abstract: Provided herein are methods and compositions for treatment of Batten disease. Such compositions include a recombinant adeno-associated virus (rAAV), said rAAV comprising an AAV capsid, and a vector genome packaged therein, said vector genome comprising (a) an AAV 5? inverted terminal repeat (ITR) sequence; (b) a promoter; (c) a CLN2 coding sequence encoding a human TPP1; (d) an AAV 3? ITR. Also provided herein are methods of treating Batten disease comprising administering to a subject in need thereof the rAAV described herein via more than one route. Also provide herein are pharmaceutical compositions comprising the rAAV described herein and related methods of treating Batten disease.

Abstract: Spray-dried thrombin materials obtained from feedstock solutions comprising less than 5% by weight albumin and excluding trehalose or other excipients as well as methods of manufacturing the thrombin materials and methods of treating bleeding wounds are disclosed. The methods of use include applying reconstituted spray-dried thrombin topically to a bleeding site, optionally in conjunction with gelatin.

Abstract: A motor comprising a frame for supporting a rotor assembly and a stator assembly, the frame comprising an inner wall and an outer wall and a plurality of diffuser vanes extending between the inner wall and outer wall; a rotor assembly comprising a shaft, a magnet, a bearing assembly and an impeller; and a stator assembly comprising a bobbin, a stator core and a winding wound round the bobbin; the impeller comprising a metal hub and an outer portion, the outer portion comprising a plurality of blades and being formed of plastic or carbon fibre composite.

Abstract: Provided is a computer implemented method for preparing a clip of one or more of a video or an audio content, comprising the steps of a) receiving an input from a user indicating a desire by the user to create a clip of the content; b) identifying of the media content and a specific time within the content the user is watching or listening to based on the digital content of the content or a digital signal associated with the content having identification information; c) creating the clip based on the specific time with a start and an end point; and d) delivering the clip (final clip) to the user. The identification can be carried out by an Automatic Content Recognition (ACR) program using one or more of pre-processed video and audio in the library as a reference for identification.

Abstract: The invention relates to a process cartridge for an image forming apparatus, wherein the cartridge includes frame and a removable toner hopper that is connected to the frame by a screw. The use of a screw as the means for attaching the hopper to the cartridge frame simplifies assembly and remanufacture/refilling of the cartridge.

Abstract: A bearing is provided at each longitudinal end of the cartridge frame. The bearing has mounting apertures for mounting the developing roller and regulating blade, and for maintaining a predetermined spacing between the developing roller and the regulating blade. The bearing is moveable relative to the cartridge frame to allow relative movement between the developing roller and photosensitive drum. A coil spring is also provided to bias the bearing toward the drum to create the required gap between the developing roller and drum. The gap is maintained by spacers mounted on the longitudinal ends of the developing roller. In addition, an abutting portion is provided on the bearing and is engageable with a stop portion on the cartridge frame to limit movement of the bearing toward the operative position photosensitive member.

Abstract: A cover (4) adapted for protecting a photosensitive member (2) of a process cartridge (1), the cover (4) comprising a filter (5) adapted to capture airborne particles from air flowing around or through the cover (4). Preferably, the filter (5) takes the form of a High Efficiency Particulate Air Filter, or “HEPA”, which contains micron sized pores for capturing the very smallest airborne particles.