Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A compressed unit dose toilet cleaning tablet for use with a wand. The composition contains an anionic surfactant, a carbonate or bicarbonate salt, an organic acid, and about 10% to about 40% by weight polyethylene glycol having molecular weight greater than 3,350. A unit dose of the composition is compressed into a tablet or puck that dissolves in toilet water after cleaning.

Abstract: A knotless tissue repair assembly for attachment of tissue to bone includes an anchoring implant with a length of suture threaded therethrough. The implant is preferably a soft flexible three-dimensional structure. The implant may be actuated from a first elongate low profile shape into a second short radially expanded shape having a larger diameter than the hole through which it was placed. The suture extends through the anchor, through a tissue to be secured, and back through a designated suture-binding region or passageway within the anchor enabling the suture to be secured therein and without the need for a physician to tie a knot. Further tension applied to a suture leg approximates the tissue to the anchor until a desired tension or distance between the tissue and anchor is achieved.

Abstract: A knotless tissue repair assembly for attachment of tissue to bone includes an anchoring implant with a length of suture threaded therethrough. The implant is preferably a soft flexible three-dimensional structure. The implant may be actuated from a first elongate low profile shape into a second short radially expanded shape having a larger diameter than the hole through which it was placed. The suture extends through the anchor, through a tissue to be secured, and back through a designated suture-binding region or passageway within the anchor enabling the suture to be secured therein and without the need for a physician to tie a knot. Further tension applied to a suture leg approximates the tissue to the anchor until a desired tension or distance between the tissue and anchor is achieved.

Abstract: Low-pH compositions are provided for dissolvable solid unit dose formulations that can be used with a wand apparatus to clean a toilet surface. The formulations include surfactants, an organic acid and an organic acid buffering agent, and virgin soap pellets and/or a cellulose filler. Formulations having antibacterial efficacy include an anionic surfactant present at about 15% to about 30% by weight of the composition, an organic acid-buffer system in an amount sufficient to provide toilet water with a pH which is less than 4.6 when the composition is dissolved in toilet water, and virgin soap pellets.

Abstract: A compressed unit dose toilet cleaning tablet for use with a wand. The unit dose contains surfactant, organic acid, and an organic acid buffering agent and is compressed into a tablet or puck that dissolves in toilet water after cleaning. The tablet has a top surface, a bottom surface, a height extending from the top surface to the bottom surface, and a diameter. The top surface has an indentation adapted to receive and engage with a wand. A ratio of the height to the diameter of the tablet is between 0.2 and 0.3. A kit contains a plurality of the tablets and a wand.

Abstract: A dissolvable toilet cleaning solid tablet includes an anionic surfactant; virgin soap pellets; and borax, and desirably, a carbonate or bicarbonate salt; and an acid. The borax comprises about 0.5% to about 10% by weight of the composition, and the virgin soap pellets comprise about 12% to about 25% by weight of the composition.

Abstract: A cleaning system includes a handling tool for a dissolvable cleaner block. The handling tool includes a wand and a retainer arrangement attached to the wand and moveable between a retaining position and a releasing position. The retainer arrangement is configured for removably attaching the wand to the dissolvable cleaner block when in the retaining position. The retainer arrangement is configured for releasing the dissolvable cleaner block when in the releasing position. The retainer arrangement includes at least one selectively moveable engagement member that removably engages the dissolvable cleaner block in the retaining position.

Abstract: A graft suspension device for suspending a ligament in a bone hole having a first loop and a second loop suspending from an 8-hole anchor, and a cradle at the opposite end of the loops to the anchor. The loose ends of the suture are routed through holes in the anchor separate from the loops and are joined together to form a single tail. A finger loop allows a surgeon to adjust the distance of the cradle from the anchor with the cradle staying centered with respect to the anchor as the distance is adjusted.

Abstract: A knotless tissue repair assembly for attachment of tissue to bone includes an anchoring implant with a length of suture threaded therethrough. The implant is preferably a soft flexible three-dimensional structure. The implant may be actuated from a first elongate low profile shape into a second short radially expanded shape having a larger diameter than the hole through which it was placed. The suture extends through the anchor, through a tissue to be secured, and back through a designated suture-binding region or passageway within the anchor enabling the suture to be secured therein and without the need for a physician to tie a knot. Further tension applied to a suture leg approximates the tissue to the anchor until a desired tension or distance between the tissue and anchor is achieved.

Abstract: A graft suspension device for suspending a ligament in a bone hole having a first loop and a second loop suspending from an 8-hole anchor, and a cradle at the opposite end of the loops to the anchor. The loose ends of the suture are routed through holes in the anchor separate from the loops and are joined together to form a single tail. A finger loop allows a surgeon to adjust the distance of the cradle from the anchor with the cradle staying centered with respect to the anchor as the distance is adjusted.

Abstract: A method for determining the presence of an odorous material on a fabric includes applying a benzofurazan indicator to the fabric, tagging the odorous material with the indicator, exposing the fabric to a light at a predefined wavelength to produce fluorescence of the tagged odorous material, and observing the fluorescence of the tagged odorous material through a bandpass filter. Also disclosed is a system including the fabric, the indicator applied to the fabric and configured to tag the odorous material, at least one light source arranged about the fabric and configured to direct light on the fabric to produce fluorescence of the tagged odorous material, and an imaging device arranged about the fabric to capture an image of the fabric through a bandpass filter with the image including at least one illuminated portion representing the tagged odorous material. Also disclosed is a method for determining the efficacy of a laundry product.

Abstract: A graft suspension device for suspending a ligament in a bone hole having a first loop and a second loop suspending from an 8-hole anchor, and a cradle at the opposite end of the loops to the anchor. The loose ends of the suture are routed through holes in the anchor separate from the loops and are joined together to form a single tail. A finger loop allows a surgeon to adjust the distance of the cradle from the anchor with the cradle staying centered with respect to the anchor as the distance is adjusted.

Abstract: A graft suspension device for suspending a ligament in a bone hole having a first loop and a second loop suspending from an 8-hole anchor, and a cradle at the opposite end of the loops to the anchor. The loose ends of the suture are routed through holes in the anchor separate from the loops and are joined together to form a single tail. A finger loop allows a surgeon to adjust the distance of the cradle from the anchor with the cradle staying centered with respect to the anchor as the distance is adjusted.

Abstract: A graft suspension device for suspending a ligament in a bone hole having a first loop and a second loop suspending from an 8-hole anchor, and a cradle at the opposite end of the loops to the anchor. The loose ends of the suture are routed through holes in the anchor separate from the loops and are joined together to form a single tail. A finger loop allows a surgeon to adjust the distance of the cradle from the anchor with the cradle staying centered with respect to the anchor as the distance is adjusted.