Abstract: The present disclosure relates to compositions and methods of uses of a monoallelic MHC-expressing cell line, as well as method of identifying a neoepitope-MHIC binding pair and methods of treating a subject having a cancer or tumor expressing a neoantigen and a MHC allele.

Abstract: Described herein is a kit of materials prepared for assays that involve determining relative abundance and/or absolute abundance of various targeted peptides. The kit may comprise trigger versions of target peptides with masses offset from the respective target peptides by predetermined and known amounts. The trigger peptides may be present in amounts that may be readily detected via a mass spectrometry analysis. When mixed with samples that are analyzed, detection of the trigger peptides indicates where in the mass-spectrometer output the target peptide may be found. The kit may include a predetermined amount of synthetic versions of one or more of the target peptides. A measured relative abundance of this synthetic peptide relative to that of the target peptides yields an absolute quantitative value of the target peptide. Also disclosed is a method of preparing a plurality of samples to be submitted for mass spectrometer analysis in parallel.

Abstract: Described herein is a kit of materials prepared for assays that involve determining relative abundance and/or absolute abundance of various targeted peptides. The kit may comprise trigger versions of target peptides with masses offset from the respective target peptides by predetermined and known amounts. The trigger peptides may be present in amounts that may be readily detected via a mass spectrometry analysis. When mixed with samples that are analyzed, detection of the trigger peptides indicates where in the mass-spectrometer output the target peptide may be found. The kit may include a predetermined amount of synthetic versions of one or more of the target peptides. A measured relative abundance of this synthetic peptide relative to that of the target peptides yields an absolute quantitative value of the target peptide. Also disclosed is a method of preparing a plurality of samples to be submitted for mass spectrometer analysis in parallel.

Abstract: An RPG defeat system and method wherein a foam body is placed at a proximate a target. The foam body has a sufficiently low density to be pierceable by an RPG sensor without the RPG sensor being strained sufficiently to create a voltage. The foam body has a compressive strength sufficient to deform the RPG short circuiting a voltage pathway from the sensor to the RPG detonator. The foam body has a sufficient thickness and/or is spaced from the target to deform the RPG short circuiting the voltage pathway from the sensor to the RPG detonator before the sensor strikes the target and is strained creating a voltage.

Abstract: The present invention relates to a method of transmitting information using computer systems loaded with appropriate software. Such software may allow a method of transmitting information through executing a series of steps, starting with the software receiving intended recipient information from a sender of information, and in turn also receiving details from a sender of a storage location within the sender's computer system at which information to be transmitted is stored. Such software can then transmit all the information stored within the sender's computer system at the storage location detailed to an intended recipient or recipient for such information.