Abstract: Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12C mutation) and treating diseases or disorders such as cancers in subjects in need thereof.

Abstract: Provided herein are compounds of formula (I) and (II), or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12D mutation) and treating diseases or disorders such as cancers in subjects in need thereof.

Abstract: In some embodiments, a system may be configured to process survey results together with associated location and timing information to automatically determine the reliability of the survey data. In certain embodiments, the system may be configured to receive captured data including survey responses and at least one of timing data, location data, keystroke data, and audio data. The system may be further configured to automatically determine a reliability score associated with each of the survey responses from the captured data. In some embodiments, the system may be configured to identify fake or false survey data or reliable survey data based on the reliability score.

Abstract: An apparatus, system, and method are disclosed for integrating the steps of securing and aligning a ramp to the pallet. A pallet mounting bracket secures to a pallet and mates with a corresponding ramp mounting bracket secured to a ramp. A pallet mounting bracket includes a registration receptacle that receives a registration member secured to the ramp mounting bracket in order to position the ramp with respect to the pallet. A driving member secured to the pallet mounting bracket engages a corresponding engagement portion on the ramp mounting bracket as the ramp is lowered into place next to the pallet. The driving member urges the engagement portion toward the pallet thereby urging a fastener secured to the ramp mounting bracket into engagement with a locking portion secured to the pallet mounting bracket thereby locking the ramp into position in alignment with the pallet.

Abstract: An apparatus, system, and method are disclosed for integrating the steps of securing and aligning a ramp to the pallet. A pallet mounting bracket secures to a pallet and mates with a corresponding ramp mounting bracket secured to a ramp. A pallet mounting bracket includes a registration receptacle that receives a registration member secured to the ramp mounting bracket in order to position the ramp with respect to the pallet. A driving member secured to the pallet mounting bracket engages a corresponding engagement portion on the ramp mounting bracket as the ramp is lowered into place next to the pallet. The driving member urges the engagement portion toward the pallet thereby urging a fastener secured to the ramp mounting bracket into engagement with a locking portion secured to the pallet mounting bracket thereby locking the ramp into position in alignment with the pallet.

Abstract: An apparatus, system, and method are disclosed for integrating the steps of securing and aligning a ramp to the pallet. A pallet mounting bracket secures to a pallet and mates with a corresponding ramp mounting bracket secured to a ramp. A pallet mounting bracket includes a registration receptacle that receives a registration member secured to the ramp mounting bracket in order to position the ramp with respect to the pallet. A driving member secured to the pallet mounting bracket engages a corresponding engagement portion on the ramp mounting bracket as the ramp is lowered into place next to the pallet. The driving member urges the engagement portion toward the pallet thereby urging a fastener secured to the ramp mounting bracket into engagement with a locking portion secured to the pallet mounting bracket thereby locking the ramp into position in alignment with the pallet.

Abstract: A packaging system for a component is disclosed. The packaging system comprises a box and a compressible and shock-absorbent packing insert. The packing insert is placed in the box after nesting a component within the insert. The insert comprises a main panel, a first end tube hingedly coupled to the main panel, a second end tube hingedly coupled to the main panel opposite the first end tube, a first side tube hingedly coupled to the main panel, the first side tube being adjacent to the first end tube and a second side tube hingedly coupled to the main panel, the second side tube being adjacent to the second end tube and opposite the first side tube wherein the first and second side tube panels and the first and second side tube panels may include at one or more cutouts to enhance the flexing capability of the packing insert.

Abstract: A packaging assembly comprising a standard molded cushion solution that can accommodate variations in dimensions of predetermined products, including weight, while providing protection to an equipment component (or other fragile or breakable item) enclosed therein, ease in use during pre-packing and packing of an equipment component for transport, shock protection during transport, and is economically suited for its end use, is provided for. The present invention is a molded, cushion having interlocking columns which adjust the contacting areas of the cushion in relation to the product height and/or weight differences. The present invention is advantageously designed using specific geometries and interlocking columns which, contrary to traditional designs, benefit from the stressing and flexing characteristics of paper fiber.

Abstract: A packaging system for a component is disclosed. The packaging system comprises a box and a compressible and shock-absorbent packing insert. The packing insert is placed in the box after nesting a component within the insert. The insert comprises a main panel, a first end tube hingedly coupled to the main panel, a second end tube hingedly coupled to the main panel opposite the first end tube, a first side tube hingedly coupled to the main panel, the first side tube being adjacent to the first end tube and a second side tube hingedly coupled to the main panel, the second side tube being adjacent to the second end tube and opposite the first side tube wherein the first and second side tube panels and the first and second side tube panels may include at one or more cutouts to enhance the flexing capability of the packing insert.