Abstract: Among other things, the present disclosure provides oligonucleotides, compositions and methods thereof that can bring about specific editing of a target adenosine in a target RNA molecule. Such oligonucleotides, compositions and methods are useful to treat, prevent, or ameliorate MECP2 associated disorders, diseases and syndromes that can benefit from adenosine modification.

Abstract: A toy system of foam panels having a novel edge design that permits panels to being resistant to separation without the application of an additional force whether orientated in a planar manner, orthogonally or any angle therebetween is described.

Abstract: An ostomy appliance includes a substrate and at least one Radio Frequency Identification (RFID) circuit disposed on the substrate. The RFID circuit includes a RFID transponder having an antenna and a conductive ink connected in series with the antenna and the RFID transponder. The conductive ink is configured to dissolve in response to exposure to moisture. The RFID circuit is in a closed condition when the conductive ink extends continuously between the RFID transponder and the antenna. The RFID circuit is in an open condition when at least a portion of the conductive ink is dissolved.

Abstract: A method of forming a part includes 3D printing a photopolymerizable resin and forming a preformed part and subsequently post-curing the preformed part with electron beams. The preformed part may be cured via UV curing. A section of the preformed part post-cured with electron beams may have a thickness of at least 1.0 centimeter, for example, at least 2.0 centimeters or at least 3.0 centimeters. An electron beam dosage to post-cure the preformed part may be between 10 kilogray (kGy) and 100 kGy. The preformed part may be 3D printed using stereolithography (SLA), digital light processing (DLP) or material jetting (MJ) and the photopolymerizable resin may include at least one of an acrylate functional polymer and a methacrylate functional polymer. In the alternative, or in addition to, the photopolymerizable resin may include at least one of a urethane, a polyester, and a polyether.

Abstract: The present invention provides engineered carboxyesterase enzymes having improved properties as compared to a naturally occurring wild-type carboxyesterase enzymes, as well as polynucleotides encoding the engineered carboxyesterase enzymes, host cells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes in amidation reactions.

Abstract: A siding panel includes a hanger section adjacent to an upper edge and a lower locking section adjacent to a lower edge. When installed, the lower locking section of an upper siding panel partially overlaps, extends into, and interlocks with a hanger section of a lower siding panel in an interference fit.

Abstract: Described herein are systems, apparatuses, processes (also referred to as methods), and computer-readable media (collectively referred to as “systems and techniques”) for improving an accuracy of determinations made using data sensed in a wellbore. Such systems and techniques may use a combination of sampled data and simulated data to generate updated datasets that may be used to make evaluations about how well a casing is cemented to subterranean formations where a wellbore is located.

Abstract: A light assembly may include a base comprising a first electrical connector configured to be connected to a first electrical wire, a light module removably attachable to the base and comprising a source of light, a first electrical terminal positioned on the base or the light module and formed in a circle, and a second electrical terminal positioned on the other of the base or the light module to contact the first electrical terminal when the light module is removably attached to the base.

Abstract: A method of assembling a deck board by using a step clip fastening device is disclosed. The method comprising the steps of fastening the step clip fastening device onto a joist by using a plurality of fastening tools; sliding a first end of the deck board into an inner cavity of a step clip attached at a first end of the step clip fastening device; and snapping a second end of the deck board into an inner cavity of a corresponding step clip facing the step clip attached at the first end of the step clip fastening device to form a mating relationship between the deck board and the step clip fastening device.

Abstract: A novel door and partition assembly for transit vehicles is provided. The door extends from the floor to the ceiling of the transit vehicle and the partition extends from the floor to the ceiling of the transit vehicle and to the windshield and dashboard area such that passengers cannot reach around the door and partition assembly into the operator's area. A novel locking mechanism is provided having an external and internal release mechanism which allows the operator to enter and exit the operator's area of a transit vehicle having the novel door and partition assembly.

Abstract: A method for biometric authentication has the steps of sending a confidential communication to an intended recipient through the system, the intended recipient providing one or more biometric identifiers to view the communication, wherein the one or more biometric identifiers are unique to the intended recipient, the system verifying the one or more biometric identifiers against one or more stored biometric identifiers, the system accepting the one or more biometric identifiers further has the steps of the system displaying the confidential communication on the mobile device, and the user continues to provide the one or more biometric identifiers, the system continuously verifying the one or more biometric identifiers while the communication is displayed wherein when the verification is uninterrupted of fails the communication is hidden.

Abstract: A novel maize variety designated X95V292 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X95V292 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X95V292 through backcrossing or genetic transformation, and to the maize seed, plant and plant part produced thereby are described. Maize variety X95V292, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X95V292 are provided. Methods for producing maize varieties derived from maize variety X95V292 and methods of using maize variety X95V292 are disclosed.

Abstract: An apparatus configured to detect small particles of a substance suspended in a matrix using ultrasound, may include: a container device configured to receive a sample in an inner volume, including: a first ultrasonic transducer mechanically coupled to or disposed on a first exterior portion of the container device and oriented toward the inner volume, the first ultrasonic transducer may include: a first ultrasonic transmitter; and a first ultrasonic receiver; optionally a first receiver amplifier coupled to the first receiver; optionally the first transmitter amplifier coupled to the first transmitter amplifier; and either: a) a software defined radio (SDR), or b) a signal generator and an oscilloscope, where SDR or signal generator and oscilloscope are electronically coupled to the first ultrasonic transmitter and electronically coupled to the first ultrasonic receiver amplifier; and the electronic controller coupled to the SDR or the signal generator and the oscilloscope.

Abstract: A processing system provides two-way communication between an electroanatomic navigation and mapping system (EAMS) and a head-mounted display (HMD). A user wearing the HMD can use hands-free or touch-free actions to interact with a user interface for EAMS information displayed by the HMD (e.g., 3D augmented reality graphics) or by a display monitor (e.g., 2D graphics). For example, the processing system updates the position of a cursor on the display monitor to track a gaze direction of the user as determined by the HMD.

Abstract: A method for friction reduction during professional network expansion is implemented via a computing system including a processor. The method includes executing, via a network, an enterprise application on a remote computing system operated by a user associated with an enterprise and surfacing a professional networking UI on a display of the remote computing system during execution of the enterprise application. The method includes generating parameters that are representative of a connection between the user and each suggested professional contact based on enterprise-level data corresponding to the user and each suggested professional contact and generating friction-reducing UI elements for each suggested professional contact based on the generated parameters.

Abstract: A method for preparing an aluminosilicate molecular sieve having the SSY framework structure is described. The method includes (1) a step of preparing a reaction mixture containing an aluminosilicate zeolite having an FAU framework type; N-ethyl-N-(3,3,5-trimethylcyclohexyl)pyrrolidinium cations and/or N-ethyl-N-(2,4,4-trimethylcyclopentyl)pyrrolidinium cations; an alkali metal; hydroxide ions; seed crystals; and water; and (2) a step of subjecting the reaction mixture to crystallization conditions sufficient to form crystals of the aluminosilicate molecular sieve. The resulting molecular sieves are useful as catalysts, particularly when used in combination with exchanged transition metal(s).

Abstract: A method for manufacturing micronized rubber powders including grinding of a rubber granulated feedstock, size classification and storage of the micronized rubber powders thus obtained. A rubber formulation including at least one natural or synthetic rubber, a micronized rubber composition and optionally one or more of processing aids, antidegradants, fillers, accelerators and curatives. A method for manufacturing a rubber product, as well as to a solid rubber product.

Abstract: A set of alternative vocal input styles for specifying a parameter of a dialog-driven application is determined. During execution of the application, an audio prompt requesting input in one of the styles is presented. A value of the parameter is determined by applying a collection of analysis tools to vocal input obtained after the prompt is presented. A task of the application is initiated using the value.

Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.

Abstract: An electric vehicle drive unit includes an electric motor generating a torque. An input differential splits the torque into a first torque created by a first side gear and a second torque created by a second side gear. A first pinion gear shaft assembly receives the first torque and has a first pinion gear. A second pinion gear shaft assembly receives the second torque and has a second pinion gear. A first stage transfer gear assembly has a first, a second, a third, and a fourth transfer gear. A first stage speed reduction meshes the first pinion gear with the first transfer gear and the third transfer gear, and meshes the second pinion gear, the second transfer gear and the fourth transfer gear. A second stage gear assembly engages the first stage transfer gear assembly and includes a first final drive gear and a second final drive gear.