Abstract: A monitoring apparatus includes: input reception circuitry configured to receive a signal indicative of a characteristic of rotating assembly rotation; and bearing wear monitoring circuitry configured to analyze the signal characteristic of rotating assembly rotation. The bearing wear monitoring circuitry is also configured to identify one or more signal features indicative of bearing wear. Bearing wear produces variation in rolling friction of the bearing and therefore is one cause of variation in shaft torque. Aspects recognise that variations in shaft torque can be indirectly monitored, measured and/or determined by appropriate measurement or monitoring of operational characteristics of a pump motor and that it may be possible to distinguish variations in shaft torque which can be attributed to bearing wear from those variations in shaft torque caused by one or more other factors.

Abstract: The present invention provides novel methods of identifying, monitoring or determining the risk of developing a protein misfolding neurodegenerative disorder in a subject, particularly an alpha synucleinopathy (including Parkinson's disease and dementia with Lewy bodies) using extracellular vesicle samples. Corresponding methods for selecting a treatment and assaying for the presence of a pathological prion-like protein (or one or more ceramide species) in an extracellular vesicle sample are also provided.

Abstract: Systems, methods and devices for nitric oxide generation are provided for use with various ventilation and/or medical devices and having a humidity control system associated therewith. In some embodiments, a system for generating nitric oxide comprises at least one pair of electrodes configured to generate a product gas containing nitric oxide from a reactant gas, a scrubber configured to remove nitric dioxide NO2 from the product gas, and a humidity control device configured to alter a water content of at least one of the reactant gas and the product gas to control humidity within the system.

Abstract: Methods are disclosed for analyzing sequence data to identify putative structural variants (SVs), filter out germline SVs and artifacts from sample handling and sequencing to leave only somatic SVs. Recognizing that those somatic SVs, especially where sequenced from a tumor or other sample of diseased tissue, may be indicative of the presence of disease, methods may include designing primers to selectively amplify those somatic SVs for monitoring disease progression or recurrence in patient samples including blood. In various embodiments, the original sequence data may be obtained from FFPE-extracted or fresh frozen-extracted DNA and somatic SVs may be identified without the benefit of a matched normal sequence. In some embodiments, machine learning analysis may be used in the identification of SVs, the filtering of artifacts and germline SVs, and/or primer and probe design for disease monitoring.

Abstract: The present invention provides novel methods of identifying, monitoring or determining the risk of developing a protein misfolding neurodegenerative disorder in a subject, particularly an alpha synucleinopathy (including Parkinson's disease and dementia with Lewy bodies) using extracellular vesicle samples. Corresponding methods for selecting a treatment and assaying for the presence of a pathological prion-like protein (or one or more ceramide species) in an extracellular vesicle sample are also provided.

Abstract: A computer implemented method includes accessing training data that includes images, associated alternative text, and proximately located text providing instructions describing a user interface. The images are paired with text captions derived from the proximately located text and image's alternative text, training a vision and language model in a self-supervised manner using language masking, region masking, and image-text alignment techniques on respective image region features and tokenized text captions. Fine-tuning of the vision and language model is performed to obtain a specialized model representing user interface elements and associated functions.

Abstract: Systems and methods for managing content provenance are provided. A network system accesses a plurality of documents. The plurality of documents is then hashed to identify one or more content features within each of the documents. In one embodiment, the hash is a MinHash. The network system compares the content features of each of the plurality of documents to determine a similarity score between each of the plurality of documents. In one embodiment, the similarly score is a Jaccard score. The network system then clusters the plurality of documents into one or more clusters based on the similarity score of each of the plurality of documents. In one embodiment, the clustering is performed using DBSCAN. DBSCAN can be iteratively performed with decreasing epsilon values to derive clusters of related but relatively dissimilar documents. The clustering information associated with the clusters are stored for use during runtime.

Abstract: Systems, methods and devices for nitric oxide generation are provided for use with various ventilation and/or medical devices and having a humidity control system associated therewith. In some embodiments, a system for generating nitric oxide comprises at least one pair of electrodes configured to generate a product gas containing nitric oxide from a reactant gas, a scrubber configured to remove nitric dioxide NO2 from the product gas, and a humidity control device configured to alter a water content of at least one of the reactant gas and the product gas to control humidity within the system.

Abstract: Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.

Abstract: Systems and methods are provided for delivering one or more drugs. In some embodiments, a drug delivery system includes a housing having a distal end with an inlet through which an inspiratory flow of air passes into the housing, a proximal end having a patient interface attached thereto, the patient interface being configured to interface with a user, and an inspiratory flow pathway extending from the distal end to the proximal end of the housing. A nitric oxide (NO) source is positioned within the housing and is configured to deliver NO-containing gas to the patient interface. A secondary drug source is positioned within the housing and is configured to deliver a secondary drug to the patient interface. A controller is configured to control an amount of NO-containing gas and an amount of the secondary drug delivered using a control scheme.

Abstract: System and methods are provided for generating nitric oxide (NO). In some embodiments, systems comprise a microwave generator configured to produce microwave energy of varying pulse duration, pulse frequency, and power level and a microwave cavity configured to utilize microwave energy to generate a plasma ball within a flow of reactant gas containing nitrogen and oxygen flowing through the microwave cavity to produce a product gas containing NO. At least one stub can be positioned in the microwave cavity and is configured to focus the microwave energy at a location at which the plasma ball is formed. A controller in electrical communication with the microwave generator can be configured to control the microwave generator to initiate and maintain the plasma ball so the plasma ball is suspended in the flow of reactant gas and does not contact a surface of the at least one stub and the microwave cavity.

Abstract: A set of unstructured data is analyzed to infer structural elements from the unstructured data, and quantized data quality levels, indicative of data quality in the structural elements, are assigned to the structural elements. A set of structured data is generated to include the structural elements inferred from the unstructured data and associations between respective ones of the structural elements in the set of structured data and the corresponding quantized quality levels assigned to the structural elements. The set of structured data, including the associations between respective ones of the structural elements and the corresponding quantized quality levels assigned to the structural elements, is provided to a user interface application to enable the user interface application to visually display varying data qualities in the set of structured data.

Abstract: Techniques for synthesizing and analyzing data are disclosed. A ML model anonymizes microdata to generate synthesized data. This anonymizing is performed by reproducing attributes identified within microdata and by applying constraints to prevent rare attribute combinations from being reproduced in the synthesized data. User input selects attributes to filter the synthesized data, thereby generating a subset of records. A UI displays a synthesized aggregate count representing how many records are in the subset. Pre-computed aggregate counts are accessed to indicate how many records in the microdata embody certain attributes. Based on the user input, there is an attempt to identify a particular count from the pre-computed aggregate counts. This count reflects how many records of the microdata would remain if the selected attributes were used to filter the microdata. That count is displayed along with the synthesized aggregate count. The two counts are juxtaposed next to one another.

Abstract: Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.

Abstract: Systems and methods for managing content provenance are provided. A network system accesses a document of a plurality of documents to be analyzed. The network system extracts text fragments from the document including a first fragment and a second fragment. A determination is made whether each of the text fragments match an entry in a hash table. Based on a first fragment not matching any entries in the hash table, the network system creates a new entry in the hash table, whereby the first fragment is used to generate a key in the hash table. Based on a second fragment matching an entry of the hash table, the network system associates the document with a key of the matching entry in the hash table, whereby the associating comprising updating the hash table with an identifier of the document.

Abstract: A system and method for managing operation of electrical devices includes a control module that monitors status of multiple sources of electrical power to one or more electrical devices and electrical usage of the one or more electrical devices that receive electricity from the source of electrical power. The operation of the one or more electrical devices is managed using a machine learning model that forecasts status of the at least one source of electrical power and generates operational rules for the one or more electrical devices from historical values of control parameters of the one or more electrical devices, the status of the source of electrical power, and the electrical usage of the one or more electrical devices. The system may optimize renewable energy utilization, power grid stabilization, cost of electrical power usage, and the like.

Abstract: A system can include a processor; memory operatively coupled to the processor; a display operatively coupled to the processor; a touch sensitive surface that comprises a slider region; and assignment circuitry that assigns one of a plurality of assignable system functions to the slider region.

Abstract: Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.

Abstract: A turbo pump vent assembly and method are disclosed. The turbo pump vent assembly comprises: a primary manual actuator operable to deliver an initial volume of air to a turbo pump; and a secondary manual actuator operable to deliver a secondary volume of air to the turbo pump, wherein the secondary volume of air is greater than the initial volume of air. In this way, an uncomplex and reliable vent is provided which can deliver initial volumes of air to slow the turbo pump initially. Thereafter, the secondary volume of air may be delivered to slow the turbo pump more rapidly than is possible just using further initial volumes of air. Having an apparatus which can deliver differing volumes of air enables the turbo pump to be slowed safely and more quickly than is possible by delivering just the same sized volumes of air.