Publication number: 20060189623
Abstract: The invention is directed to compounds of Formula I: wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.
Type:
Application
Filed:
April 20, 2006
Publication date:
August 24, 2006
Inventors:
Carl Illig, Shelley Ballentine, Jinsheng Chen, Sanath Meegalla, M. Rudolph, Mark Wall, Kenneth Wilson, Renee Desjarlais, Carl Manthey, Christopher Flores, Christopher Molloy
Publication number: 20060100201
Abstract: The invention relates to compounds of Formula I: wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.
Type:
Application
Filed:
October 20, 2005
Publication date:
May 11, 2006
Inventors:
Carl Illig, Shelley Ballentine, Jinsheng Chen, Sanath Meegalla, M. Jonathan Rudolph, Mark Wall, Kenneth Wilson, Renee DesJarlais, Carl Manthey, Christopher Flores, Christopher Molloy