Abstract: The present disclosure provides anti-tau antibodies and adeno-associated virus (AAV) particles with an AAV genome encoding anti-tau antibodies. Also provided are methods of using anti-tau antibodies and AAV particles for treatment and diagnosis of neurological indications.

Abstract: The disclosure relates to compositions and methods for the preparation, use, and/or formulation of adeno-associated virus capsid protein variants.

Abstract: The disclosure relates to compositions and methods for the preparation, use, and/or formulation of adeno-associated virus capsid protein variants.

Abstract: The disclosure relates to compositions and methods for altering, e.g., enhancing, the expression of GCase proteins, whether in vitro and/or in vivo. Such compositions include delivery of an adeno-associated viral (AAV) particle. The compositions and methods of the present disclosure are useful in the treatment of subjects diagnosed with, or suspected of having Parkinson Disease or related condition resulting from a deficiency in the quantity and/or function of GBA gene product or associated with decreased expression or protein levels of GCase protein.

Abstract: The disclosure provides compositions and methods for the preparation, manufacture and use of an adeno-associated virus (AAV) particle for the vectorized delivery of an antibody molecule that binds to tau.

Abstract: The disclosure relates to compositions, formulations, and methods for the preparation, use, and/or formulation of adeno-associated virus capsid protein variants.

Abstract: The disclosure relates to compositions and methods for the preparation, use, and/or formulation of adeno-associated virus capsid protein variants.

Abstract: The disclosure relates to compositions and methods for the preparation, use, and/or formulation of adeno-associated virus capsid protein variants.

Abstract: A money and card carrier assembly includes a first component having a first portion, wherein the first portion includes a plurality of pockets formed therein. Each of the plurality of pockets is sized to allow a credit card to be releasably retained therein. The assembly also includes a second portion, with a first hinge connecting the first portion and the second portion. A second component has a sleeve sized to allow the second portion of the first component to be removably inserted therein and a plurality of pockets located on either side of the sleeve. Each of the plurality of pockets is sized to allow a credit card to be releasably retained therein. A third component has a first generally planar portion, a second generally planar portion, and a second hinge connecting the first generally planar portion to the second generally planar portion. Each of the first and second generally planar portions is sized to be removably insertable into the sleeve.

Abstract: An electronic charging cable assembly is disclosed. The assembly includes a power connection end adapted to be electrically connected to an electrical power source and a device connection end adapted to be logically connected to an electronic device. The device connection end is electrically connected to the power connection end. A light source is located at the device connection end such that, when the power connection end is electrically connected to the electrical power source and the device connection end is not connected to the electronic device, the light source is illuminated and, when the power connection end is electrically connected to the electrical power source and the device connection end is connected to the electronic device, the light source is not illuminated. An exemplary electrical circuit used to provide this feature and a method of operating the electronic charging cable assembly are also disclosed.

Abstract: A system and method are provided to monitor informational resources, such as websites. A plurality of host units support one or more informational resources accessible over a network, such as the Internet. A plurality of monitoring units located on a distributed computer system are coordinated to access the network and monitor the informational resources to determine if they are accessible and to evaluate their performance. Preferably, a central control unit manages the monitoring units.