Abstract: A radar module for process automation including process measurement technology and the automation industry is provided, the radar module including: a radar signal source configured to generate and to transmit, and/or to receive, a radar signal; and a dielectric radar signal guide configured to receive the radar signal and then to transmit the radar signal to an antenna, a waveguide, and/or a dielectric lens, the dielectric radar signal guide being arranged at a predetermined distance from the radar signal source, forming an intermediate space, and an end face of the dielectric radar signal guide facing the radar signal source at least partially has a metallic layer.

Abstract: An assembly of an optical system, comprising at least one mirror with a mirror main body, in which there is a fluid channel arrangement with at least one fluid channel through which a fluid can flow. The fluid channel arrangement is coupled to a fluid line system via a detachable flange connection. The flange connection comprises a flange interface formed on the mirror main body and a flange force-lockingly mounted on the flange interface. A seal is formed between the flange and the flange interface in order to provide a differential vacuum.

Abstract: The present disclosure relates to new antibody-drug-conjugates (ADCs) comprising a favorable modular linker linking the pharmaceutically active drug substance with the antibody. The present disclosure further relates to methods of producing the antibody-drug conjugate as well as to uses thereof and pharmaceutical compositions comprising the same. Embodiments of the present disclosure have been particularly developed as antibody-drug conjugates for use in the treatment of Guanylate Cyclase 2C (GUCY2C)-positive gastrointestinal cancers and will be described hereinafter with reference to this application. However, it will be appreciated that the present disclosure is not limited to this particular field of use.

Abstract: The present disclosure relates to modular linker compounds for target-binding drug conjugates (TBDCs) and in particular to modular linker compounds for antibody-drug-conjugates (ADCs). The present disclosure further relates to methods of synthesizing the modular linker compound, to target-binding drug conjugates comprising the modular linker compound of the present disclosure as well as to pharmaceutical compositions comprising target-binding drug conjugates compound of the present disclosure. Embodiments of the present disclosure have been particularly developed as target-binding drug conjugates for use in the treatment of cancer and will be described hereinafter with reference to this application. However, it will be appreciated that the present disclosure is not limited to this particular field of use.

Abstract: The present document related to the processing of mining materials, such as ores, rocks, minerals, and aggregate materials to separate valuable components. There is provided a process and system for extracting a valuable component from a mining feedstock comprising geological materials. The process can comprise subjecting the mining feedstock to a kinetic pulverization stage wherein the mining feedstock is subjected to self-collisions created by vortices within the kinetic pulverizer to produce a pulverized material; admixing the mining feedstock or the pulverized material with a chemical additive configured to selectively liberate the valuable component from the geological material; and subjecting the pulverized material to an extraction stage to produce a valuable component-rich stream and a valuable component-depleted stream.

Abstract: The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6?-deoxy position; and (ii) an amino acid 8 with an S-deoxy position; (b) a target-binding moiety; and (c) optionally a linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate.

Abstract: A rotor assembly for a pulverizer, the pulverizer including a housing and a rotatable shaft rotatably mounted in the housing, the rotor assembly comprising: a hub mountable on the rotatable shaft; a plurality of rotor arms extending outwardly from the hub for pulverizing material received in the housing when the rotatable shaft is rotated; wherein the hub including a plurality of hub sections connectable together to form the hub, the hub sections being separable from each other and movable radially outwardly away from the rotatable shaft.

Abstract: A pulverizer comprising: a housing having top and bottom ends, an inlet located towards the top end for receiving input material to pulverize and an outlet located towards the bottom end for discharging pulverized material from the housing, the housing including a housing sidewall defining an interior chamber and having a central housing axis: a rotatable shaft extending along the central housing axis: a plurality of rotor hub assemblies mounted to the shaft, each rotor hub assembly including a rotor hub and a plurality of rotor arms extending outwardly from the rotor for forming an airflow revolving about the central housing axis within the interior chamber, wherein at least one of the housing and of one or more of the rotor hub assemblies is selectively reconfigurable between a plurality of configurations to adjust at least one parameter of an output flow of the pulverized material at the outlet.

Abstract: A temperature sensor assembly including a carrier part having a receptacle for a temperature pin, a sensor element for measuring a temperature, and a pushing element pushing the sensor element into the receptacle.

Abstract: A process for treating a fines stream in a material recover facility (MRF), comprising: providing an MRF fines stream comprising breakable material and ductile material: subjecting the MRF fines streams to a one-pass kinetic pulverization stage to produce a pulverized material comprising a size-reduced fraction derived from the breakable material and an oversized fraction derived from the ductile material; withdrawing the pulverized material from the kinetic pulverizer; and subjecting the pulverized material to separation to produce a size-reduced stream and an oversized stream. Also provided is a system comprising a kinetic pulverizer, a pulverizer conveyor and a screen operatively coupled to the pulverizer conveyor to receive a pulverized stream and produce a sized-reduced stream and an oversized stream. The system can also include a magnetic separator and a dust collection system respectively located upstream and downstream of the kinetic pulverizer.

Abstract: A radio frequency unit for use in a potentially explosive atmosphere is provided, including: a carrier element, on which a radio frequency element is arranged, the radio frequency element being configured to transmit and/or receive a radio frequency signal; a housing, which delimits the radio frequency element at least in sections; and an excitation element arranged on the radio frequency element and configured to transmit the radio frequency signal, an inside of the housing being potted with a potting compound. A fill level measuring device including the radio frequency unit , and a method of manufacturing the radio frequency unit, are also provided.

Abstract: A radar circuit for a measuring device is provided, including: a radar chip, configured to generate a radar measurement signal; an application-specific integrated circuit (ASIC); and a processor, configured to determine a measured value, the ASIC and the radar chip being separate components.

Abstract: A radar circuit for a level measuring device is provided, including: a first application-specific integrated circuit (ASIC); and a second ASIC, the first ASIC having a first structure size and/or being manufactured by a first semiconductor technology, the second ASIC having a second structure size and/or being manufactured by a second semiconductor technology, the first structure size being different from the second structure size, and/or the first semiconductor technology being different from the second semiconductor technology.

Abstract: A waveguide coupling device for a radar sensor is provided, including: a waveguide configured to emit a radar signal via a radiating end of the waveguide; and a fin part with at least one excitation fin, via which a radio frequency (RF) signal can be coupled into the waveguide for generating the radar signal, the waveguide and the fin part being formed in two parts, and the fin part being mechanically coupled to an excitation end of the waveguide opposite the radiating end of the waveguide.

Abstract: A measuring device for process automation in an industrial or private environment is provided, including: a sensor circuit configured to detect one or more measured variables; and a control circuit configured to determine a measurement result from the detected one or more measured variables and to determine a difference between a temperature of the sensor circuit and a reference temperature detected during a calibration of a self-test function of the measuring device, the control circuit being further configured to perform a correction of the measurement result depending on the difference between the temperature of the sensor circuit and the reference temperature during execution of the self-test function. A method for performing a correction of a measurement result of a measuring device for process automation in an industrial or private environment is also provided.

Abstract: Marfan Syndrome is a pathology responsible for a high morbidity and mortality. Apart from surgery, treatment options are limited. It is therefore essential to develop new pharmacological approaches to limit aortic dilatation and/or rupture. Now, the inventors have demonstrated a critical role for TREM-1 in the pathophysiology of ascending aortopathy related to Marfan disease, In particular, the inventors showed that i) TREM-1 is expressed by macrophages in the aortic wall of Marfan patients, ii) TREM-1 is expressed by macrophages in the aortic wall of Marfan mice, and iii) TREM-1 deficiency protects against aortic rupture in a mouse model of Marfan syndrome. Blocking TREM-1 could therefore be a therapeutic approach for Marfan-related aortopathy.

Abstract: The present disclosure relates to the treatment of streams derived from construction and/or demolition (C&D) debris, such as C&D fines streams, asphalt shingles, drywall, or wood. The process can include a kinetic pulverization stage through a kinetic pulverizer where the frangible materials are size-reduced and the ductile materials are liberated and remain as an oversized fraction. The feedstock can include infrangible materials that also remains as an oversized fraction. The pulverized material is then subjected to a separation stage, which may include mechanical and/or magnetic screening, to separate the oversized material comprising the ductile material, and optionally larger particles of the infrangible material, from the size-reduced material comprising the frangible material, and optionally small particles of infrangible material.

Abstract: A placeable cooktop utensil includes: a handle for handling the placeable utensil; a controller; a transmitter unit for transmitting signals from the placeable utensil to the cooktop; and at least one input unit having at least one input area integrated in the handle for a user of the placeable utensil to input a user command, the transmitter unit and the at least one input unit being connected in signal communication with the controller, and the cooktop being controllable by the user command. The handle has a gripping portion for gripping and manually moving the placeable utensil and at least one input portion. The at least one input area is in the at least one input portion. At least one sensor for detecting the handle being approached and/or contacted by the user, is in the gripping portion.

Abstract: A waveguide coupling device for a radar sensor is provided, including: a waveguide configured to emit a radar signal via a radiating end of the waveguide; and a fin part with at least one excitation fin, via which a radio frequency (RF) signal can be coupled into the waveguide for generating the radar signal, the waveguide and the fin part being formed in two parts, and the fin part being mechanically coupled to an excitation end of the waveguide opposite the radiating end of the waveguide.

Abstract: The present invention relates to a computer-implemented method for identifying an incorrectly or non-calibrated infrared spectrometer, comprising the steps of a) recording an infrared spectrum of a sample with a first infrared spectrometer to provide a sample infrared spectrum, b) recording an infrared spectrum of the same sample as in step a) with a second infrared spectrometer to provide a reference infrared spectrum, wherein said second spectrometer is a correctly calibrated infrared spectrometer, or b?) providing a reference spectrum of the same sample as in step a), wherein said reference spectrum was recorded on a second infrared spectrometer, which is a correctly calibrated spectrometer, c) determining a difference between the wavelength of each extreme point in the sample of step a) and the wavelength of each extreme point in the reference spectrum of step b) or b?), and d) indicating the infrared spectrometer of step a) as incorrectly calibrated or non-calibrated, when at least one difference was det