Abstract: Disclosed herein are therapeutic applications of CRISPR/Cpf1-based genome editing.

Abstract: A method for tracking and assessing a wound includes identifying a wound from an image output by a camera, identifying a set of wound features based on the image, detecting a temperature of the wound from at least one heat sensor, triggering at least one response if the wound temperature is outside of a therapeutic temperature zone, processing the set of wound features and wound temperature using machine learning, determining an optimal wound healing trajectory based on the set of wound features and the wound temperature using machine learning, predicting at least one future wound condition based on the optimal wound healing trajectory using machine learning, and displaying the optimal wound healing trajectory and the at least one future wound condition on a display.

Abstract: Fusion proteins are provided, the fusion proteins comprising a single-chain trimer coupled to an Fc domain of an antibody. Also provided are methods of use thereof.

Abstract: Disclosed herein are therapeutic applications of CRISPR/Cpf1-based genome editing.

Abstract: A sole for an article of footwear includes an outsole that has longitudinal ribs and a midsole that is disposed above the outsole and that defines notches. The longitudinal ribs arc disposed in the notches.

Abstract: A method includes receiving subject training data comprising a plurality of images of subjects in a plurality of positions on a person support apparatus, labeling the plurality of images based on the positions of the subjects to generate labeled subject training data, generating synthetic training data comprising computer generated images of artificial subjects in a plurality of positions on an artificial person support apparatus, labeling the synthetic training data based on the positions of the artificial subjects to generate labeled synthetic training data, and training a machine learning model based on the labeled subject training data and the labeled synthetic training data, using supervised learning techniques, to generate a trained model to predict a subject position based on an image of the subject.

Abstract: Embodiments of the present disclosure pertain to a method of expressing a nucleic acid sequence in a cell by inserting the nucleic acid sequence at a region of a creatine kinase (CKM) and/or a myoglobin (MB) gene such that the inserted nucleic acid sequence becomes expressed in the cell by a promoter of the gene. The nucleic acid sequences may be expressed in vitro or in vivo for various purposes, such as treatment or prevention of a disease and/or tissue repair or regeneration. Additional embodiments pertain to a system for expressing a nucleic acid sequence in a cell after insertion at a region of a creatine kinase (CKM) gene and/or a myoglobin (MB) gene. Further embodiments of the present disclosure pertain to a modified cell that includes an inserted nucleic acid sequence at a region of a creatine kinase (CKM) gene and/or a myoglobin (MB) gene.

Abstract: A patient monitoring system includes a computing device that having a processor and a memory, the memory comprising instructions that, when executed, cause the system to receive, from a thermographic camera, at least one image corresponding to a temperature of a region of interest and a surrounding area that surrounds the region of interest; use an artificial intelligence model to analyze the at least one image; detect a difference in temperature of the region of interest relative to the surrounding area; and issue an alert related to an incontinence event when the difference in temperature exceeds a threshold value.

Abstract: A system for incontinence prediction includes an electrical impedance tomography (EIT) device, a posture detector, and one or more processors communicatively coupled to the EIT device and the posture detector. The EIT device may include a plurality of electrodes configured to be worn at a lower abdomen of a user around the bladder. The one or more processors is configured to collect an EIT image generated by the EIT device, a posture generated by the posture detector, and a planning activity of the user. The one or more processors may further determine a bladder status based on the EIT image of the user, predict an incontinence risk based on the bladder status, the posture, and the planning activity of the user and determine a high-risk point indicating a high incontinence risk, and notify the user or a caregiver of the high incontinence risk at the high-risk point.

Abstract: A disposable, wearable article can be used for collecting a sample and performing urinalysis. The article incorporates a test port feature to simplify this function. The test port has a resealable cover that can be used to selectively expose an aperture through the backsheet of the disposable article. The test port is used to position test devices, such as urine test strips to urine collected in the disposable article.

Abstract: A sole for an article of footwear includes an outsole that has longitudinal ribs and a midsole that is disposed above the outsole and that defines notches. The longitudinal ribs are disposed in the notches.

Abstract: A system is disclosed for generating synthetic patient data. The system includes one or more patient data monitoring devices, and a computing device that receives patient data from the one or more patient data monitoring devices. The system receives patient data from the one or more patient data monitoring devices. The system analyzes the patient data in real-time to learn one or more characteristics. The system generates synthetic patient data based on the one or more characteristics. The synthetic patient data including data representative of the patient data that is different from the patient data. The system stores the synthetic patient data in a database.

Abstract: Disclosed herein are vision systems. The vision systems may be integrated into person support apparatuses, or may be integrated into mobile carts such that the vision systems are movable relative to the person support apparatus. The vision system includes at least one camera positioned such that a field of view of the at least one camera contains the person support apparatus and the subject positioned thereon. The vision system also includes a computer communicatively coupled to the at least one camera. The computer is configured to receive at least one image from the at least one camera and determine a tidal volume of the subject positioned on the person support surface from the at least one image.

Abstract: A disposable, wearable article can be used for collecting a sample and performing urinalysis. The article incorporates a test port feature to simplify this function. The test port has a resealable cover that can be used to selectively expose an aperture through the backsheet of the disposable article. The test port is used to position test devices, such as urine test strips to urine collected in the disposable article.

Abstract: A method for determining an electromagnetic field spatial distribution of a radio frequency (RF) antenna which includes the steps of emitting with the RF antenna, a plurality of RF energy pulses into a homogeneous medium; performing a plurality of thermoacoustic signal measurements of the plurality of RF energy pulses, wherein each of the thermoacoustic signal measurements is performed in a similar manner; utilizing a variance in the plurality of thermoacoustic signal measurements to generate a reconstructed pressure distribution for a volume located within the homogeneous medium; and calculating the RF antenna electromagnetic field spatial distribution within the volume based upon the reconstructed pressure distribution for the volume located within the homogeneous medium.

Abstract: A main memory includes a first plurality of input/outputs (I/Os) configured to output data stored in the main memory in response to a read access request. A first portion of the first plurality of IOs provides user read data in response to the read access request and a second portion of the first plurality of IOs provides candidate replacement IOs. Repair circuitry is configured to selectively replace one or more IOs of the first portion of IOs using one or more of the candidate replacement IOs of the second portion of IOs to provide repaired read data in response to the read access request in accordance with repair mapping information corresponding to an access address of the read access request. A static random access memory (SRAM) stores repair mapping information, and a repair cache stores cached repair mapping information from the SRAM for address locations of the main memory.

Abstract: A main memory includes a first plurality of input/outputs (I/Os) configured to output data stored in the main memory in response to a read access request. A first portion of the first plurality of IOs provides user read data in response to the read access request and a second portion of the first plurality of IOs provides candidate replacement IOs. Repair circuitry is configured to selectively replace one or more IOs of the first portion of IOs using one or more of the candidate replacement IOs of the second portion of IOs to provide repaired read data in response to the read access request in accordance with repair mapping information corresponding to an access address of the read access request. A static random access memory (SRAM) stores repair mapping information, and a repair cache stores cached repair mapping information from the SRAM for address locations of the main memory.

Abstract: A recirculation pump includes an impeller, a pump motor assembly, and a heater. The pump motor assembly includes a pump housing having a pump cavity and a pump motor arranged in the pump cavity that drives the impeller, the pump housing arranged axially away from the impeller. The heater is disposed on or in the pump housing and spaced apart from the impeller. The heater is configured to increase a temperature of any portion of the fluid that leaks from the impeller into the pump cavity and resides in the pump cavity. The increase in the temperature causes the fluid that resides in the pump cavity to flow toward the impeller and exit the pump cavity.

Abstract: The present disclosure is directed to compositions and methods of treating arthritogenic alphavirus infection. Compositions include a fusion protein comprising an Fc region, a first Mxra8 region, and a second Mxra8 region, wherein the fusion protein reduces inflammation and infection by an arthritogenic alphavirus. Methods include administering the fusion protein to a mammalian or non-mammalian subject to reduce or inhibit alphavirus infection.

Abstract: An apparatus includes a controller configured to: analyze image data within an area; determine an object is present in the area based on the image data; determine if the object is a potential hazard based on the image data; and in response to determining the object is a potential hazard, emitting a projection beam onto a surface of the area to illuminate the object.