Patents by Inventor Christopher NICOLAI

Christopher NICOLAI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250051801
    Abstract: Provided are viral particles for activating and transducing immune cells in vitro or in vivo, and compositions and methods for using said viral particles.
    Type: Application
    Filed: October 30, 2024
    Publication date: February 13, 2025
    Inventors: Christopher NICOLAI, Jim QIN, Wai-hang LEUNG, Ryan LARSON, Alyssa SHEIH, Byoung RYU
  • Publication number: 20250041415
    Abstract: Provided are compositions and methods for a cell population comprising engineered cytotoxic innate lymphoid cells engineered for controlled expansion and/or activity, the engineered cytotoxic innate lymphoid cells comprising a synthetic cytokine receptor for a non-physiological ligand. The cytokine receptor may comprise a synthetic gamma chain polypeptide as a first dimerization domain, a first transmembrane domain, and an interleukin-2 receptor subunit gamma (IL-2RG) intracellular domain and a synthetic beta chain polypeptide as a second dimerization domain, a second transmembrane domain, and an intracellular domain selected from an interleukin-2 receptor subunit beta (IL-2RB) intracellular domain, an interleukin-7 receptor subunit beta (IL-7RB) intracellular domain, and/or an interleukin-21 receptor subunit beta (IL-21RB) intracellular domain.
    Type: Application
    Filed: December 16, 2022
    Publication date: February 6, 2025
    Applicant: Umoja Biopharma, Inc.
    Inventors: Samantha O'HARA, Andrew SCHARENBERG, Ryan CRISMAN, Christopher NICOLAI, Teisha ROWLAND, Ryan LARSON, Ryan KONING, Christopher GARBE, David VERIEDE, Byoung RYU
  • Publication number: 20240141375
    Abstract: Provided are compositions and methods for transducing immune cells in vivo where a viral particle comprising a polynucleotide encoding a chimeric antigen receptor and a multipartite cell-surface receptor is administered to a subject.
    Type: Application
    Filed: January 26, 2022
    Publication date: May 2, 2024
    Inventors: Andrew Scharenberg, Christopher Nicolai, Ryan Crisman, Alessandra Sullivan, Kathryn Michels, Byoung Ryu, Shon Green, Laurie Beitz, Susana Hernandez Lopez
  • Publication number: 20230348624
    Abstract: Provided are compositions and methods for transducing immune cells in vivo where a multispecific antibody (e.g. a bispecific T-cell engager) is administered to render immune cells in the subject more transducible by a vector, such as a lentiviral vector.
    Type: Application
    Filed: January 27, 2021
    Publication date: November 2, 2023
    Inventors: Andrew SCHARENBERG, Ryan CRISMAN, Christopher NICOLAI, Alessandra SULLIVAN, Kathryn MICHELS, Byoung RYU, Shon GREEN, Laurie BEITZ, Susana HERNANDEZ LOPEZ