Abstract: Compounds and compositions are disclosed in which a NAMPT Drug Unit is conjugated to a targeting Ligand Unit through quaternization by a Linker Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as those of cancer or an autoimmune disease, using the compounds and compositions of the invention are also disclosed.

Abstract: An interactive fire safety education kit includes a frame having a first section, a second section conjoined to the first section, and a third section conjoined to the second section. A first fire-simulating mechanism is rotatably coupled to the first section, a second fire-simulating mechanism adjustably coupled to the second section, and a third fire-simulating mechanism rotatably coupled to the third section. A flag and an associated mechanism are provided wherein the mechanism is capable of reciprocating the flag along a vertical path located adjacent to the third section as the third fire-simulating mechanism rotates in opposing rotational directions. A user interface is provided wherein the user interface is capable of generating an output that causes selective rotational displacement of the first fire-simulating mechanism, selective linear displacement of the second fire-simulating mechanism, and selective rotational displacement of the third fire-simulating mechanism, respectively.