Abstract: A cassette for a heated fluid ablation system, comprises a fluid supply lumen receiving an ablation fluid from an external fluid source and a fluid chamber containing a therapeutic agent in combination with an impeller pumping the ablation fluid out of the cassette via to a fluid delivery lumen when the cassette is in a first configuration and pumping the therapeutic agent out of the cassette via the fluid delivery lumen when the cassette is in a second configuration.

Abstract: A system for accessing a patient's body may include an elongate member having a proximal end, a distal end, and two lumens. The elongate member may include two lumens and a thickness of material extending between external and internal surfaces of the elongate member. The system may also include a first illumination device associated with a first of the two lumens such that a portion of the first illumination device may extend into the thickness of material. A second illumination device may be associated with the second of the two lumens such that a portion of the second illumination device may extend into the thickness of material. Further, the system may include an imaging device having a first portion extending into the thickness of material, a second portion protruding into the first of the two lumens, and a third potion protruding into the second of the two lumens.

Abstract: A system for accessing a patient's body may include an elongate member having a proximal end, a distal end, and two lumens. The elongate member may include two lumens and a thickness of material extending between external and internal surfaces of the elongate member. The system may also include a first illumination device associated with a first of the two lumens such that a portion of the first illumination device may extend into the thickness of material. A second illumination device may be associated with the second of the two lumens such that a portion of the second illumination device may extend into the thickness of material. Further, the system may include an imaging device having a first portion extending into the thickness of material, a second portion protruding into the first of the two lumens, and a third portion protruding into the second of the two lumens.

Abstract: A steering mechanism is used as part of a medical device such as a catheter or an endoscope to allow movement of a steerable distal portion of the catheter or endoscope. The mechanism can include a elongate housing and an actuation system. The elongate housing is adapted to be coupled to the steerable portion of the medical device. The actuation system includes an actuator, a first cam, and a second cam. The actuator can move the first cam between a first position and a second position as the actuator is moved along a first axis (or about a second axis different than the first axis). Movement of the first cam between its first and second positions moves the steerable portion of the medical device along a first plane. The actuator can move the second cam between a first position and a second position as the actuator is moved along the second axis (or about the first axis).

Abstract: The present description relates to fluid sealant compositions that increase in viscosity upon administration to a subject, to medical procedures employing such compositions, to methods for administering such compositions, and to products containing such compositions including medical devices, medical device components and kits, among other aspects.

Abstract: In one embodiment, an apparatus may include a first capillary component. A second capillary component may be disposed outside of the first capillary component and may have an inner surface, wherein a portion of the inner surface may be heat-fused to an outer surface of the first capillary component. The apparatus may also include a portion of an optical fiber disposed inside of the first capillary component and the portion of the optical fiber can have an outer surface. A portion of the outer surface of the optical fiber may be heat-fused to an inner surface of the first capillary component. The optical fiber may have a distal surface configured to reflect electromagnetic radiation propagated along a longitudinal axis of a distal end portion of the optical fiber in a lateral direction through the inner surface of the first capillary component and the inner surface of the second capillary component.

Abstract: A steering mechanism is used as part of a medical device such as a catheter or an endoscope to allow movement of a steerable distal portion of the catheter or endoscope. The mechanism can include a elongate housing and an actuation system. The elongate housing is adapted to be coupled to the steerable portion of the medical device. The actuation system includes an actuator, a first cam, and a second cam. The actuator can move the first cam between a first position and a second position as the actuator is moved along a first axis (or about a second axis different than the first axis). Movement of the first cam between its first and second positions moves the steerable portion of the medical device along a first plane. The actuator can move the second cam between a first position and a second position as the actuator is moved along the second axis (or about the first axis).

Abstract: A steering mechanism is used as part of a medical device such as a catheter or an endoscope to allow movement of a steerable distal portion of the catheter or endoscope. The mechanism can include a elongate housing adapted to be coupled to the steerable portion of the medical device and an actuation system including an actuator, a first cam, and a second cam. The actuator can move the first cam between a first position and a second position along a first axis (or about a second axis different than the first axis) to move the steerable portion of the medical device along a first plane. The actuator can move the second cam between a first position and a second position along the second axis (or about the first axis) to move the steerable portion of the medical device along a second plane different than the first plane.

Abstract: A cassette for a heated fluid ablation system, comprises a fluid supply lumen receiving an ablation fluid from an external fluid source and a fluid chamber containing a therapeutic agent in combination with an impeller pumping the ablation fluid but of the cassette via to a fluid delivery lumen when the cassette is in a first configuration and pumping the therapeutic agent out of the cassette via the fluid delivery lumen when the cassette is in a second configuration.

Abstract: Introducer Device comprises (a) Housing including (1) Housing Lumen sized and shaped to slidably receive a visualization device therein and (2) Slot sized to receive therein a projection extending from visualization device received in Lumen radially away from Lumen; (b) Sheath extending distally from handle and being sized and shaped for insertion through a natural body opening into a hollow body organ, Sheath including a fluid delivery lumen delivering heated fluid to the organ and a fluid return lumen withdrawing the fluid after it has been circulated through the organ; (c) Connector including Connector Lumen aligned with Lumen and sized and shaped to slidably receive therein visualization device; (d) Locking arrangement movably coupled to Housing, movement relative to the housing opening and closing Slot; and (e) Adjustment mechanism moving Connector relative to Housing to adjust distance between a proximal end of Connector Lumen and a distal end of Sheath.

Abstract: A system for accessing a patient's body may include an elongate member having a proximal end, a distal end, and two lumens. The elongate member may include two lumens and a thickness of material extending between external and internal surfaces of the elongate member. The system may also include a first illumination device associated with a first of the two lumens such that a portion of the first illumination device may extend into the thickness of material. A second illumination device may be associated with the second of the two lumens such that a portion of the second illumination device may extend into the thickness of material. Further, the system may include an imaging device having a first portion extending into the thickness of material, a second portion protruding into the first of the two lumens, and a third portion protruding into the second of the two lumens.

Abstract: A cassette for a heated fluid ablation system, comprises a fluid supply lumen receiving an ablation fluid from an external fluid source and a fluid chamber containing a therapeutic agent in combination with an impeller pumping the ablation fluid out of the cassette via to a fluid delivery lumen when the cassette is in a first configuration and pumping the therapeutic agent out of the cassette via the fluid delivery lumen when the cassette is in a second configuration.

Abstract: An apparatus for treating tissue, comprising a sheath defining a lumen sized and shaped to receive a treatment device therein, a guide member coupled to the sheath and extending a predetermined distance substantially parallel to a longitudinal axis of the sheath, and a stabilizer element for engaging an anchoring device coupled to tissue to stabilize the sheath and the treatment device, the stabilizing element being movably coupled to the guide member for movement therealong substantially parallel to the longitudinal axis of the sheath wherein, when in a proximal-most position, the stabilizer element is located proximally of a proximal end of the guide member.

Abstract: A hand-holdable steering mechanism is used as part of a medical device such as a catheter or an endoscope to allow movement of a steerable distal portion of the catheter or endoscope. The mechanism can include a housing and an actuation system. The actuation system is adapted for one-handed operation by a user, and it allows the user to achieve 360 degree articulation of the steerable distal portion. The actuation system can include a first actuator and a second actuator where the first and second actuators are movable with respect to each other. The first actuator can be at least partially disposed within the second actuator.

Abstract: Introducer Device comprises (a) Housing including (1) Housing Lumen sized and shaped to slidably receive a visualization device therein and (2) Slot sized to receive therein a projection extending from visualization device received in Lumen radially away from Lumen; (b) Sheath extending distally from handle and being sized and shaped for insertion through a natural body opening into a hollow body organ, Sheath including a fluid delivery lumen delivering heated fluid to the organ and a fluid return lumen withdrawing the fluid after it has been circulated through the organ; (c) Connector including Connector Lumen aligned with Lumen and sized and shaped to slidably receive therein visualization device; (d) Locking arrangement movably coupled to Housing, movement relative to the housing opening and closing Slot; and (e) Adjustment mechanism moving Connector relative to Housing to adjust distance between a proximal end of Connector Lumen and a distal end of Sheath.

Abstract: A hand-holdable steering mechanism is used as part of a medical device such as a catheter or an endoscope to allow movement of a steerable distal portion of the catheter or endoscope. The mechanism can include a housing and an actuation system. The actuation system is adapted for one-handed operation by a user, and it allows the user to achieve 360 degree articulation of the steerable distal portion. The actuation system can include a first actuator and a second actuator where the first and second actuators are movable with respect to each other. The first actuator can be at least partially disposed within the second actuator.

Abstract: Introducer Device comprises (a) Housing including (1) Housing Lumen sized and shaped to slidably receive a visualization device therein and (2) Slot sized to receive therein a projection extending from visualization device received in Lumen radially away from Lumen; (b) Sheath extending distally from handle and being sized and shaped for insertion through a natural body opening into a hollow body organ, Sheath including a fluid delivery lumen delivering heated fluid to the organ and a fluid return lumen withdrawing the fluid after it has been circulated through the organ; (c) Connector including Connector Lumen aligned with Lumen and sized and shaped to slidably receive therein visualization device; (d) Locking arrangement movably coupled to Housing, movement relative to the housing opening and closing Slot; and (e) Adjustment mechanism moving Connector relative to Housing to adjust distance between a proximal end of Connector Lumen and a distal end of Sheath.

Abstract: The present description relates to fluid sealant compositions that increase in viscosity upon administration to a subject, to medical procedures employing such compositions, to methods for administering such compositions, and to products containing such compositions including medical devices, medical device components and kits, among other aspects.

Abstract: A hand-holdable steering mechanism is used as part of a medical device such as a catheter or an endoscope to allow movement of a steerable distal portion of the catheter or endoscope. The mechanism can include a housing and an actuation system. The actuation system is adapted for one-handed operation by a user, and it allows the user to achieve 360 degree articulation of the steerable distal portion. The actuation system can include a first actuator and a second actuator where the first and second actuators are movable with respect to each other. The first actuator can be at least partially disposed within the second actuator.

Abstract: In one embodiment, an apparatus may include a first capillary component. A second capillary component may be disposed outside of the first capillary component and may have an inner surface, wherein a portion of the inner surface may be heat-fused to an outer surface of the first capillary component. The apparatus may also include a portion of an optical fiber disposed inside of the first capillary component and the portion of the optical fiber can have an outer surface. A portion of the outer surface of the optical fiber may be heat-fused to an inner surface of the first capillary component. The optical fiber may have a distal surface configured to reflect electromagnetic radiation propagated along a longitudinal axis of a distal end portion of the optical fiber in a lateral direction through the inner surface of the first capillary component and the inner surface of the second capillary component.