Patents by Inventor Christopher P. Bryant

Christopher P. Bryant has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxidation-resistant muteins of .beta.-galactosidase fragments
    Patent number: 5464747
    Abstract: A mutein of an enzyme acceptor polypeptide fragment of .beta.-galactosidase which is resistant to oxidation is provided. The enzyme acceptor fragment has an amino acid other than cysteine located at position 602 of the natural sequence. An especially preferred substitution is serine. Also provided are a method for producing the novel mutein, a reagent composition comprising the novel mutein, and an immunoassay method for determining an analyte in which the novel mutein recombines with an enzyme donor polypeptide fragment to form enzymatically active .beta.-galactosidase.
    Type: Grant
    Filed: October 29, 1993
    Date of Patent: November 7, 1995
    Assignee: Boehringer Mannheim Corporation
    Inventors: Scott J. Eisenbeis, Mark Krevolin, Christopher P. Bryant, Sophie J. Boguslawski, David J. Ledden, Scott Clark