Patents by Inventor Christopher P. Marshall

Christopher P. Marshall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230310570
    Abstract: The present invention provides methods useful for vaccination against respiratory syncytial virus (RSV), including vaccination of juvenile subjects. In some embodiments such methods involve administration of an RSV F polypeptide stabilized in a prefusion conformation and a Th-balanced adjuvant to a juvenile subject. The present invention also provides a variety of compositions useful in such methods.
    Type: Application
    Filed: August 17, 2021
    Publication date: October 5, 2023
    Inventors: Jessica L. Kosanovich, Katherine M. Eichinger, Kerry M. Empey, Mark A. Yondola, Christopher P. Marshall
  • Publication number: 20120083008
    Abstract: The invention provides a method for reducing immunogenicity of a peptide, protein or protein complex in an individual comprising introducing at least one cross-link between two amino acids in the peptide, protein or protein complex that is stable or irreversible in vivo, wherein the at least one cross-link reduces the immunogenicity of the peptide, protein or protein complex in the individual compared to an identical peptide, protein or protein complex not so cross-linked.
    Type: Application
    Filed: June 19, 2009
    Publication date: April 5, 2012
    Inventor: Christopher P. Marshall
  • Patent number: 7445912
    Abstract: Isolated polypeptides or polypeptide chains are modified by di-tyrosine cross-linking such that they retain at least one functional activity. In one embodiment, the isolated polypeptide or polypeptide chains comprise at least one di-tyrosine cross-link, wherein at least one tyrosine of the di-tyrosine cross-link originates from a point mutation to tyrosine, and wherein the di-tyrosine cross-linked protein retains at least one function displayed by the protein in the absence of di-tyrosine cross-linking. In another embodiment, the di-tyrosine cross-linked polypeptide or polypeptide chain has enhanced stability compared to the same polypeptide or polypeptide chain in the absence of di-tyrosine cross-linking. A method for stabilization of a polypeptide or polypeptide complex, by the introduction of intra-polypeptide and/or inter-polypeptide di-tyrosine bonds, which simultaneously maintains the structure and function of the polypeptide or polypeptide complex is also described.
    Type: Grant
    Filed: January 29, 2007
    Date of Patent: November 4, 2008
    Assignee: Avatar Medical LLC
    Inventors: Christopher P. Marshall, Alexander Hoffman, Joseph P. Errico, Paul B. Marshall
  • Patent number: 7037894
    Abstract: Isolated polypeptides or polypeptide chains are modified by di-tyrosine cross-linking such that the retain at least one functional activity. In one embodiment, the isolated polypeptide or polypeptide chains comprise at least one di-tyrosine cross-link, wherein at least one tyrosine of the di-tyrosine cross-link originates from a point mutation to tyrosine, and wherein the di-tyrosine cross-linked protein retains at least one function displayed by the protein in the absence of di-tyrosine cross-linking. In another embodiment, the di-tyrosine cross-linked polypeptide or polypeptide chain has enhanced stability compared to the same polypeptide or polypeptide chain in the absence of di-tyrosine cross-linking. A method for stabilization of a polypeptide or polypeptide complex, by the introduction of intra-polypeptide and/or inter-polypeptide di-tyrosine bonds, which simultaneously maintains the structure and function of the polypeptide or polypeptide complex is also described.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: May 2, 2006
    Assignee: Avatar Medical, LLC
    Inventors: Christopher P. Marshall, Alexander Hoffman, Joseph P. Errico, Paul B. Marshall
  • Publication number: 20020061549
    Abstract: The invention described herein comprises methods for stabilizing polypeptides and polypeptide complexes, and the polypeptides and polypeptide complexes stabilized using the methods. To achieve stabilization, a cross-link reaction is controlled such that polypeptides and polypeptide complexes maintain their original functionality. In one embodiment, the invention provides a method for the identification of amino acid residues which, when cross-linked, are least disruptive to the structure and function of the polypeptide or polypeptide complex. In another embodiment, the invention provides a method for mutagenesis of identified residues to further control the cross-link reaction. Polypeptides and polypeptide complexes so stabilized can be utilized under a wide variety of physiological and non-physiological conditions.
    Type: Application
    Filed: April 18, 2001
    Publication date: May 23, 2002
    Inventors: Christopher P. Marshall, Alexander Hoffman, Joseph P. Errico, Paul B. Marshall