Abstract: The described invention provides a method of treating localized pain comprising (a) applying topically to an area of skin of a subject overlaying the localized pain a pharmaceutical composition comprising a cannabinoid component and a chemical driver component comprising two or more of methylsulfonylmethane (MSM), and ethoxydiglycol, and propylene glycol; and applying an external energy effective to enhance transdermal permeation of the pharmaceutical composition into the skin. wherein the components of the composition and the device are cooperatively effective to work together to maximize transdermal delivery of the composition, deeply penetrate the skin of the subject and to provide pain relief.

Abstract: The described invention provides pharmaceutical compositions and a topical delivery system comprising a pharmaceutical composition for application directly to a skin of a subject in need thereof, the composition comprising (a) a therapeutic amount of an active agent comprising one or more of a cannabinoid, a counterirritant and an amino benzoate local anesthetic; (b) a chemical driver component comprising two or more of ethoxydiglycol, methylsulfonylmethane (MSM), propylene glycol, that in combination are cooperatively effective to deliver the therapeutic agent; and optionally (c) a depot component for keeping the composition in the skin. Methods for delivering an active therapeutic agent into skin, for keeping it in the skin, for reducing systemic side effects attributable to entry of the active agent into the blood stream, and a method for treating a condition, disease or disorder of skin topically also are described in accordance with the embodiments of the described invention.