Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A cutter head includes a first member, a cutting bit, and a second member. The first member includes a first end and a second end and includes a first mass. The cutting bit is coupled to the first member proximate the second end. The cutting bit includes a cutting edge rotatable about the axis. The second member is rotatable about the axis and includes a second mass eccentrically positioned with respect to the axis. Rotation of the second mass causes the first member and the cutting bit to oscillate.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: A system for determining a treatment regimen for chronic pelvic pain (CPP) includes an electromyography (EMG) probe including electrodes. Each electrode detects pelvic floor muscle activity. An EMG sensor array includes bipolar EMG sensors configured to detect muscle activity of muscles associated with or supporting the pelvic floor muscles. An EMG amplifier is in communication with the EMG probe or the EMG sensor array. The EMG amplifier includes a plurality of input channels. Each input channel receives data of muscle activity in the pelvic floor muscles or the muscles associated with or supporting the pelvic floor muscles from the EMG probe or the EMG sensor array. A processor of a computer performs muscle network analysis using the data of muscle activity in the pelvic floor muscles or the muscles associated with or supporting the pelvic floor muscles. A treatment regimen for CPP is recommended based on the muscle network analysis.

Abstract: Discloses embodiments relate to a container assembly for storing herbal products and accessories. The assembly includes a housing, including a grinder compartment that includes a perforated base with frame walls surrounding the perforated base, a first side opening beneath the perforated base, and a second side opening. The assembly further includes a slidable tray configured to slide into and out of the first side opening, a perforated grinder bottom configured to fit within the frame walls of the grinder compartment, a grinder top configured to fit within the frame walls of the grinder compartment and including a plurality of grinding teeth protruding from a first surface and a receptacle structure on a second surface opposite the first surface, and a leverage device configured to slide into and out of the second side opening and including an engaging structure configured to fit into the receptacle structure of the grinder top.

Abstract: Intraday alert volume adjustment based on risk parameters is disclosed. A set of alerts associated with user transactions can be displayed to one or more human reviewers for processing. The set of alerts can be analyzed to determine whether or not the volume of alerts exceeds a threshold capacity level, which is based on a number of human reviewers available to process alerts. If the volume of alerts exceeds the threshold capacity level, alerts in the set of alerts can be prioritized based on risk in descending order and displayed to the human reviewers. In one instance, alerts below a threshold can be hidden from view of the human reviewers and optionally automatically approved. Further, prioritization can be performed dynamically as new alerts are added to the set.

Abstract: Discloses embodiments relate to a container assembly for storing herbal products and accessories. The assembly includes a housing, including a grinder compartment that includes a perforated base with frame walls surrounding the perforated base, a first side opening beneath the perforated base, and a second side opening. The assembly further includes a slidable tray configured to slide into and out of the first side opening, a perforated grinder bottom configured to fit within the frame walls of the grinder compartment, a grinder top configured to fit within the frame walls of the grinder compartment and including a plurality of grinding teeth protruding from a first surface and a receptacle structure on a second surface opposite the first surface, and a leverage device configured to slide into and out of the second side opening and including an engaging structure configured to fit into the receptacle structure of the grinder top.

Abstract: Systems, methods, and apparatuses for changing credentials for an account, or a card associated with an account are provided. A method of changing user credentials by creating a queue of credentials for facilitating access to at least one account of a user, where each credential in the queue of credentials is randomly and automatically generated using information provided by the user without additional input from the user; detecting a deactivation event relating to an account of the at least one account of the user; responsive to the detected deactivation event, deactivating a current credential for the account; and activating a new credential to facilitate access to the account, where the new credential is next in the queue of credentials.

Abstract: Identification of anomalous transaction attributes in real-time with adaptive threshold tuning is provided. A set of historical transactions conducted during a defined time period are analyzed and categorizing into defined groups. Outlier transactions are identified and removed from the set of historical transactions and a set of non-anomalous transactions are determined. When a new transaction is received, the new transaction is automatically allowed based on a determination that the subsequent transaction conforms to the set of non-anomalous transactions. Alternatively, an alert for further analysis for the new transaction is output based on a determination that the subsequent transaction does not conform to the set of non-anomalous transactions.

Abstract: Systems, methods, and apparatuses for authenticating a user based at least in part on a location of the user or a location of a user device are described. The user may be authenticated as part of a financial transaction or as part of a login process for a computing device. The user device was previously bound or associated with the user. During the authentication, a system (e.g., a financial institution computing system or a backend authentication system) requests location information from the user device. The location information may be packaged as a digital fingerprint of the user device, which can only be created from the user device. Based on the location information, the user can be authenticated thereby approving the transaction or login request.

Abstract: Intraday alert volume adjustments based on risk parameters is provided. Users may be assigned risk levels, which may be determined based on historical information. An event associated with the user may be prioritized in relation to other events received by the user or by other users. The prioritization may be events received during a predetermined time range, or until an event has been pending for longer than a predetermined interval. The various events are output according to their relative rankings, which may indicate a descending order of risk level. As newly received events are received, they may be dynamically ranked in relationship to the previously received events that have not expired.

Abstract: Identification of anomalous transaction attributes in real-time with adaptive threshold tuning is provided. A set of historical transactions conducted during a defined time period are analyzed and categorizing into defined groups. Outlier transactions are identified and removed from the set of historical transactions and a set of non-anomalous transactions are determined. When a new transaction is received, the new transaction is automatically allowed based on a determination that the subsequent transaction conforms to the set of non-anomalous transactions. Alternatively, an alert for further analysis for the new transaction is output based on a determination that the subsequent transaction does not conform to the set of non-anomalous transactions.

Abstract: Aqueous wax dispersions useful as surface modifiers for paints, inks and coatings. More particularly, aqueous particulate wax dispersions useful as surface modifiers to provide improved properties in primers, paints, inks and other coating formulations. The dispersions are stable, substantially homogenous, have a high solids concentration at low viscosities, and comply with the applicable FDA regulations for use in food packaging applications.

Abstract: Methods for enhanced yeast fermentation of plant material through the genetic modification of non-respiring yeast are provided including the introduction of a dominant mitochondrial ATP synthase gene mutation into a non-respiring yeast that entirely lacks mitochondrial DNA and transgenic yeast for the enhanced yeast fermentation of plant material lacking mitochondrial DNA while having a dominant mitochondrial ATP synthase gene mutation in the nuclear genome. Methods further include the introduction of a mitochondrial genome into a non-respiring yeast lacking the COX1, COX2, COX3, or COB gene as well as transgenic yeast having a mitochondrial genome lacking the COX1, COX2, COX3, or COB gene. Additional methods include the creation of a disrupted copy of the CAT5 nuclear gene in a non-respiring yeast as well as transgenic yeast having a disrupted copy of the CAT5 nuclear gene are also disclosed.

Abstract: Aqueous wax dispersions useful as surface modifiers for paints, inks and coatings. More particularly, aqueous particulate wax dispersions useful as surface modifiers to provide improved properties in primers, paints, inks and other coating formulations. The dispersions are stable, substantially homogenous, have a high solids concentration at low viscosities, and comply with the applicable FDA regulations for use in food packaging applications.

Abstract: Aqueous wax dispersions useful as surface modifiers for paints, inks and coatings. More particularly, aqueous particulate wax dispersions useful as surface modifiers to provide improved properties in primers, paints, inks and other coating formulations. The dispersions are stable, substantially homogenous, have a high solids concentration at low viscosities, and comply with the applicable FDA regulations for use in food packaging applications.

Abstract: Event processing for suspicious activity detection is disclosed. Financial events can be detected by receiving data from a plurality of detection channels. The data can optionally be enriched by adding additional details about events. An event or group of events is scored based on pre-defined risk factors and experience, and the resulting score can be compared to a pre-defined threshold. A case for investigation is established when the score is above the pre-defined threshold. Events for which the score is below the pre-defined threshold are sampled to provide the experience for the scoring. Events can be scored by obtaining a plurality of predictors, collecting training data regarding existing cases, and running a logistic regression to obtain weights for the predictors. The likelihood of a case for investigation resulting in a suspicious activity report can then be determined.

Abstract: Disclosed is an apparatus and method for measuring the diametral change in a cylindrical component by monitoring and measuring bending (compression and tension) effected by the diametral change in a plane perpendicular to the diameter of the cylindrical component. The apparatus for effecting the method comprises at least one web, but typically two webs, defining planes perpendicular to the diameter of the cylindrical component and strain measuring elements mounted on the web planes and arranged to sense and measure the compressive and tensile (bending) action of the strain-gauge-mounted webs.

Abstract: Disclosed is an apparatus and method for measuring the diametral change in a cylindrical component by monitoring and measuring bending (compression and tension) effected by the diametral change in a plane perpendicular to the diameter of the cylindrical component. The apparatus for effecting the method comprises at least one web, but typically two webs, defining planes perpendicular to the diameter of the cylindrical component and strain measuring elements mounted on the web planes and arranged to sense and measure the compressive and tensile (bending) action of the strain-gauge-mounted webs.