Abstract: There is provided a seal assembly comprising: a first component and a second component spaced apart from the first component so as to define a passage for the transfer of fluid from an inlet of the seal assembly to an outlet of the seal assembly, wherein the first component comprises a concavity at least partially defining the passage, and wherein no part of the second component extends into the portion of the passage bounded by the concavity.

Abstract: There is provided a seal assembly comprising: a first component and a second component spaced apart from the first component so as to define a passage for the transfer of fluid from an inlet of the seal assembly to an outlet of the seal assembly, wherein the first component comprises a concavity at least partially defining the passage, and wherein no part of the second component extends into the portion of the passage bounded by the concavity.

Abstract: A turbine for a turbo-machine is proposed in which, at a gas inlet for a turbine wheel, vanes extend from a nozzle ring though slots in a shroud. The nozzle ring and shroud are relatively rotatable about a rotational axis of the turbine by at least 0.1 degrees. In use, the nozzle ring and shroud are relatively rotated to bring one side of the vane into close contact with one surface of the slot, to inhibit leakage of gas between the vane and the slot surface. For this purpose the respective surfaces of the nozzle and slot can be configured to closely conform to each other. If there is differential thermal expansion of the shroud and nozzle ring, the nozzle ring and shroud can relatively rotate, to withdraw the vane from the edge of the slot to relieve the pressure between them.

Abstract: A valve system comprising a valve chamber at a junction of an inlet port, an outlet port and a bypass port, the inlet port configured for fluid communication with exhaust gas, the outlet port configured for fluid communication with an inlet of a turbine, and the bypass port configured for fluid communication with an exhaust aftertreatment device; a rotary valve comprising a valve rotor which rotates about a valve axis within the valve chamber between a first position to permit gas flow through the bypass port and a second position to block gas flow. At least one of the valve rotor and the valve chamber comprises a protrusion and the other comprises a recess, wherein, in the first position, the protrusion and recess are spaced from one another, and, in the second position the recess receives the protrusion such that gas flow between the protrusion and recess is substantially prevented.

Abstract: A rotary turbine bypass valve comprises a valve chamber positioned at a junction of an inlet port, an outlet port and a bypass port, the inlet port configured for fluid communication with a flow of exhaust gas from an engine, the outlet port configured for fluid communication with an inlet of a turbine, and the bypass port configured for fluid communication with an exhaust aftertreatment device; and a valve rotor supported for rotation, about a valve axis, within the valve chamber. The valve rotor is rotatable about the valve axis between a first position in which the valve rotor permits gas flow through the bypass port and a second position in which the valve rotor blocks gas flow through the bypass port.

Abstract: A turbine for a turbo-machine is proposed in which, at a gas inlet for a turbine wheel, vanes extend from a nozzle ring though slots in a shroud. The nozzle ring and shroud are relatively rotatable about a rotational axis of the turbine by at least 0.1 degrees. In use, the nozzle ring and shroud are relatively rotated to bring one side of the vane into close contact with one surface of the slot, to inhibit leakage of gas between the vane and the slot surface. For this purpose the respective surfaces of the nozzle and slot can be configured to closely conform to each other. If there is differential thermal expansion of the shroud and nozzle ring, the nozzle ring and shroud can relatively rotate, to withdraw the vane from the edge of the slot to relieve the pressure between them.

Abstract: A turbine for a turbo-machine is proposed in which, at a gas inlet for a turbine wheel, vanes extend from a nozzle ring though slots in a shroud. The nozzle ring and shroud are relatively rotatable about a rotational axis of the turbine by at least 0.1 degrees. In use, the nozzle ring and shroud are relatively rotated to bring one side of the vane into close contact with one surface of the slot, to inhibit leakage of gas between the vane and the slot surface. For this purpose the respective surfaces of the nozzle and slot can be configured to closely conform to each other. If there is differential thermal expansion of the shroud and nozzle ring, the nozzle ring and shroud can relatively rotate, to withdraw the vane from the edge of the slot to relieve the pressure between them.

Abstract: There is provided a seal assembly comprising: a first component and a second component spaced apart from the first component so as to define a passage for the transfer of fluid from an inlet of the seal assembly to an outlet of the seal assembly, wherein the first component comprises a concavity at least partially defining the passage, and wherein no part of the second component extends into the portion of the passage bounded by the concavity.

Abstract: A valve system comprising a valve chamber at a junction of an inlet port, an outlet port and a bypass port, the inlet port configured for fluid communication with exhaust gas, the outlet port configured for fluid communication with an inlet of a turbine, and the bypass port configured for fluid communication with an exhaust aftertreatment device; a rotary valve comprising a valve rotor which rotates about a valve axis within the valve chamber between a first position to permit gas flow through the bypass port and a second position to block gas flow. At least one of the valve rotor and the valve chamber comprises a protrusion and the other comprises a recess, wherein, in the first position, the protrusion and recess are spaced from one another, and, in the second position the recess receives the protrusion such that gas flow between the protrusion and recess is substantially prevented.

Abstract: A turbine for a turbo-machine is proposed in which, at a gas inlet for a turbine wheel, vanes extend from a nozzle ring though slots in a shroud. The nozzle ring and shroud are relatively rotatable about a rotational axis of the turbine by at least 0.1 degrees. In use, the nozzle ring and shroud are relatively rotated to bring one side of the vane into close contact with one surface of the slot, to inhibit leakage of gas between the vane and the slot surface. For this purpose the respective surfaces of the nozzle and slot can be configured to closely conform to each other. If there is differential thermal expansion of the shroud and nozzle ring, the nozzle ring and shroud can relatively rotate, to withdraw the vane from the edge of the slot to relieve the pressure between them.

Abstract: A rotary turbine bypass valve comprises a valve chamber positioned at a junction of an inlet port, an outlet port and a bypass port, the inlet port configured for fluid communication with a flow of exhaust gas from an engine, the outlet port configured for fluid communication with an inlet of a turbine, and the bypass port configured for fluid communication with an exhaust aftertreatment device; and a valve rotor supported for rotation, about a valve axis, within the valve chamber. The valve rotor is rotatable about the valve axis between a first position in which the valve rotor permits gas flow through the bypass port and a second position in which the valve rotor blocks gas flow through the bypass port.

Abstract: A valve system comprising a valve chamber at a junction of an inlet port, an outlet port and a bypass port, the inlet port configured for fluid communication with exhaust gas, the outlet port configured for fluid communication with an inlet of a turbine, and the bypass port configured for fluid communication with an exhaust aftertreatment device; a rotary valve comprising a valve rotor which rotates about a valve axis within the valve chamber between a first position to permit gas flow through the bypass port and a second position to block gas flow. At least one of the valve rotor and the valve chamber comprises a protrusion and the other comprises a recess, wherein, in the first position, the protrusion and recess are spaced from one another, and, in the second position the recess receives the protrusion such that gas flow between the protrusion and recess is substantially prevented.

Abstract: A pharmaceutical composition comprises M3 protein as encoded by virus MHV 68, or a homologue of said M3 protein, for use in binding to a chemokine or a chemokine analogue in vivo, or to block binding of chemokines to corresponding cell surface receptors in vivo, to produce an immunomodulatory effect, or to bind to a chemokine analogue present in a virus or parasite to block its entry into cells.