Abstract: The present disclosure provides methods for analyzing structure and/or composition of N-glycans. Such methods often involve digestion of N-glycans with multiple exoglycosidases. In some embodiments, N-glycans are digested with multiple exoglycosidases simultaneously. In some embodiments, N-glycans are digested with multiple exoglycosidases sequentially. In some embodiments, methods in accordance with the present disclosure involve comparison of cleavage products of N-glycans that have been digested with multiple exoglycosidases simultaneously to N-glycans that have been digested with multiple exoglycosidases sequentially.

Abstract: The invention provides methods, databases and systems for making glycoprotein products having defined properties.

Abstract: A diode pumped laser is disclosed having a CW level and adapted to output one or more pulses having peak power greater than the CW level thereby to provide higher peak power for use in material piercing or penetrating operations without affecting diode lifetime.

Abstract: A parking access control system and a method of its operation in association with a parking facility. A customer operates a call box to initiate a communications session with an attendant control device operated by an attendant. In particular, the customer requests the attendant to control an exit gate so as to enable the customer to exit the parking facility with a vehicle. In response, the attendant may input into the attendant control device one of several available predetermined override conditions, which will be logged as an override transaction entry in a database in memory. After the override condition is entered, then the exit gate will operate so as to enable the customer to exit the parking facility. The override transaction entry further may also include an identification of the attendant.

Abstract: Substituted pyrazolopyrimidine derivatives of formula (I) wherein Y1, Y2, Y3, Y4 represent N or C—, whereby at least two of the groups Y1 to Y4 represent a carbon atom, R1 represents chloro or bromo, R2 to R7 represent e.g. hydrogen, methyl or ethyl; and R10 and R11 independently represent e.g. hydrogen or C1-C6alkyl, are potent mGluR5 modulators and are useful for the prevention of acute and chronic neurological disorders.

Abstract: Substituted pyrazolopyrimidine derivatives of formula (I) wherein R1 represents chloro or bromo; R2, R3, R4, R5, R6 and R7 independently represent e.g. hydrogen or C1-6-alkyl; R8 represents a radical R9 or a radical R10, whereby one of the two radicals R8 represents R9 and the other radical R8 represents Ret; R9 represents e.g. a phenyl or thiophene group, and R10 represents e.g. hydrogen or methyl; are potent mGluR5 modulators and are useful for the prevention of acute and chronic neurological disorders.

Abstract: Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexanes which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compostions comprising the same, method of preparation thereof, and method of treating CNS disorders which involve disturbances of glutamatergic, serotoninergic, and nicotinic transmission, treating immunomodulatory disorders, and antimalaria, antitrypanosomal, anti-Borna virus, anti-HSV and anti-Hepatitis C virus activity.

Abstract: A tactile metronome for use by a musician generally includes a signal generator for producing an electrical signal according to a desired timing scheme and a tactile transducer in electrical communication with the signal generator. The tactile transducer, which may take the form of a piezoelectric device, a buzzer, electrodes or any substantial equivalent, is adapted to impart a tactile sensation to the musician in response to the generated electrical signal. A strap, which may be formed from an elastic material or a soft cloth material with hook and loop fasteners, is provided to secure the tactile transducer in place on the musician's body.

Abstract: Certain 1-aminoalkylcyclohexanes are systematically-active 5HT3 and nicotinic receptor antagonists and are useful in the inhibition of progression of or alleviation of conditions resulting from disturbances of serotoninergic or nicotinergic transmission giving them a wide range of utility in the treatment of CNS-disorders. Pharmaceutical compositions thereof for such purpose and method of making same, as a method-of-treating conditions which are alleviated by the employment of a 5HT3 or neuronal nicotinic receptor antagonist.

Abstract: An article, apparatus and method for attaching a roll of web material to a treated core is disclosed. The article includes a core pre-treated with adhesive and the apparatus includes an adhesive, a conveyor, an applicator unit and roller drums. The method includes activating a treated core with adhesive, aligning the activated area of the treated core with a tail end of the roll of web material, adhering the tail end of the roll of web material with the activated area of the treated core, and winding the roll of web material around the treated core.

Abstract: A tactile rhythm generator for use by an athlete in training generally includes a signal generator for producing an electrical signal according to a desired timing scheme and a tactile transducer in electrical communication with the signal generator. The tactile transducer, which may take the form of a piezoelectric device, a buzzer, electrodes or any substantial equivalent, is adapted to impart a tactile sensation to the athlete in response to the generated electrical signal. A strap, which may be formed from an elastic material or a soft cloth material with hook and loop fasteners, is provided to secure the tactile transducer in place on the musician's body.

Abstract: A metronome for use by a musician or group of musicians generally includes a signal generator for producing an electrical signal according to a desired timing scheme and one or more transducers in wireless communication with the signal generator. Each transducer, which may take the form of a piezoelectric device, a buzzer, electrodes or any substantial equivalent, is adapted to impart a sensation to the musician in response to the generated electrical signal. The wireless communication may be established with an infrared link or a radio frequency transmission system. The signal generator is under the centralized control of a conductor, bandleader, lead musician or music instructor.

Abstract: The invention relates to novel cyclic and non-cyclic propenone derivatives as well as their pharmaceutically acceptable slats. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are useful as medicaments.

Abstract: A multiple channel metronome for use by a plurality of musicians generally includes a signal generator for producing electrical signals according to desired timing schemes and a plurality of transducers in communication with the signal generator. Each transducer, which may take the form of a piezoelectric device, a buzzer, electrodes or any substantial equivalent, is adapted to impart a sensation to one of the musicians in response to one of the generated electrical signals. The communication may be established with hardwired connections, infrared links or a radio frequency transmission system. The signal generator is under the centralized control of a conductor, bandleader, lead musician or music instructor.

Abstract: A multiple channel metronome for use by a plurality of musicians generally includes a signal generator for producing electrical signals according to desired timing schemes and a plurality of transducers in communication with the signal generator. Each transducer, which may take the form of a piezoelectric device, a buzzer, electrodes or any substantial equivalent, is adapted to impart a sensation to one of the musicians in response to one of the generated electrical signals. The communication may be established with hardwired connections, infrared links or a radio frequency transmission system. The signal generator is under the centralized control of a conductor, bandleader, lead musician or music instructor. A measuring device for determining the time of sound travel between two locations is also provided.

Abstract: Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexanes which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of treating CNS disorders which involve disturbances of glutamatergic, serotoninergic, and nicotinic transmission, treating immunomodulatory disorders, and antimalaria, antitrypanosomal, anti-Borna virus, anti-HSV and anti-Hepatitis C virus activity.

Abstract: Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexanes which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of treating CNS disorders which involve disturbances of glutamatergic, serotoninergic, and nicotinic transmission, treating immunomodulatory disorders, and antimalaria, antitrypanosomal, anti-Borna virus, anti-HSV and anti-Hepatitis C virus activity.

Abstract: The invention relates to tetrahydroquinolinone derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I mGluR modulators and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.

Abstract: The invention relates to ethynyl-substituted tetrahydroquinolinone derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I mGluR modulators and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.

Abstract: The invention relates to tetrahydroquinolinone derivatives as well as their pharmaceutially acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I mGluR antagonists and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.