Abstract: An automated vacuum carton lifter has a movable chassis with at least one vacuum cup mounted thereon, oriented so as to provide for gripping the carton or box from one of its vertical sides. A slack cable sensor used to turn on and off a vacuum. Alternatively, an air valve with an associated lever can be used, wherein the valve is depressed when the apparatus engages the carton or box. A vacuum generator is operatively connected to the vacuum cup(s). A device is provided for lifting and lowering the carton or box, the device having a cable slidably mounted to an air cylinder-operated carriage retained by a track; the device being movable to a position at the balance point of the carton or box. An adjustable control handle is provided and is associated with a force transducer that controls the lifting and lowering device. A microprocessor-based controller is operatively connected to a slack cable sensor, the vacuum generator, and the device for lifting and lowering the carton or box.