Abstract: An edge server of a distributed edge compute and routing service receives a tunnel connection request from a tunnel client residing on an origin server, that requests a tunnel be established between the edge server and the tunnel client. The request identifies the hostname that is to be tunneled. An IP address is assigned for the tunnel. DNS record(s) are added or changed that associate the hostname with the assigned IP address. Routing rules are installed in the edge servers of the distributed edge compute and routing service to reach the edge server for the tunneled hostname. The edge server receives a request for a resource of the tunneled hostname from another edge server that received the request from a client, where the other edge server is not connected to the origin server. The request is transmitted from the edge server to the origin server over the tunnel.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain aldehyde dehydrogenase inhibitor compounds (also referred to herein as “ALDHI compounds”), that, inter alia, inhibit aldehyde dehydrogenase enzyme ALDH1A3. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit ALDH1A3 enzyme; to treat disorder (e.g., diseases) that are ameliorated by the inhibition of ALDHIA3 enzyme; to treat a proliferative disorder, cancer, obesity, diabetes, a cardiovascular disorder, etc.

Abstract: Disclosed are methods and systems using liquid chromatography/tandem mass spectrometry (LC-MS/MS) for the analysis of endogenous biomarkers isolated from biological samples. In certain embodiments, the samples comprise dried body fluids such as dried plasma.

Abstract: An apparatus to facilitate increasing processing resources in processing cores of a graphics environment is disclosed. The apparatus includes a plurality of processing resources to execute one or more execution threads; a plurality of message arbiter-processing resource (MA-PR) routers, wherein a respective MA-PR router of the plurality of MA-PR routers corresponds to a pair of processing resources of the plurality of processing resources and is to arbitrate routing of a thread control message from a message arbiter between the pair of processing resources; a plurality of local shared cache (LSC) sequencers to provide an interface between at least one LSC of the processing core and the plurality of processing resources; and a plurality of instruction caches (ICs) to store instructions of the one or more execution threads, wherein a respective IC of the plurality of ICs interfaces with a portion of the plurality of processing resources.

Abstract: A request is received from a client device over a Virtual Private Network (VPN) tunnel. The request is received at a first one of a plurality of edge servers of a distributed cloud computing network. A destination of the request is determined and an optimized route for transmitting the request toward an origin server is determined. The optimized route is based at least in part on probe data between edge servers of the distributed cloud computing network. The request is transmitted to a next hop as defined by the optimized route.

Abstract: The present disclosure relates to menstrual fluid simulant compositions that mimic the properties of real menstrual fluid, where the menstrual fluid simulant compositions comprise vesicle dispersions of quaternary ammonium compounds and linear polymers. The present disclosure also relates to related methods and uses.

Abstract: Disclosed are methods and systems for the analysis activity of enzyme disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) in a sample. The methods and systems disclosed herein can be useful for diagnosis of thrombotic thrombocytopenic purpura in a patient.

Abstract: An absorbent structure comprising one or more absorbent layers wherein the absorbent structure exhibits a first cycle Peak Force compression between about 30 grams and about 150 grams. The absorbent structure further exhibits a fifth cycle dry recovery energy between 0.1 mJ and 2.8 mJ.

Abstract: A tunnel is established between a first edge server of a distributed edge compute and routing service and a tunnel client residing on an origin server. Routing rules are installed in the edge servers of the distributed edge compute and routing service to reach the first edge server. The routing rules are based at least in part on traffic information gathered from processing other traffic that traverses the distributed edge compute and routing service. A request for content served by the origin server through the tunnel is received at a second edge server of the distributed edge compute and routing service. A path from the second edge server to the first edge server is determined based on the routing rules. The request is transmitted on the determined path. The first edge server receives the request and transmits the request to the origin server over the tunnel.

Abstract: A disposable absorbent article is described herein. The disposable absorbent article includes a topsheet, a backsheet, and an absorbent system disposed between the topsheet and the backsheet. At least a portion of the has a plurality of conforming features such that the absorbent article has a blot residual value of less than 30 mg and a bending stiffness of less than 12.

Abstract: An electronic textile system and a docking assembly for the electronic textile system. The system includes a textile substrate, an input device attached to the textile substrate, and a docking assembly attached to the textile substrate for removably receiving a controller device. The docking assembly includes a first electrical interface for mating with a second electrical interface of the controller device. The system includes an electrical conductive pathway network integrated in the textile substrate for electrically coupling the input device and the first electrical interface. The input device may transmit to the controller device electronic signals representing input data when the controller device is received by the docking assembly.

Abstract: A disposable absorbent article has a topsheet; a backsheet; an absorbent core disposed between the topsheet and the backsheet; and a first plurality of conforming features in at least the absorbent core or a combination of the absorbent core and the topsheet. At least a portion of the are depressions, wherein the depressions have a depression centerline bisecting a length and/or width of the depression. A first strut forms a first sidewall of the depression opposite a second sidewall of the depression formed by a second strut, wherein neither of the first strut nor the second strut extend longitudinally and/or laterally beyond the depression centerline by more than 0.75 mm.

Abstract: A method including rendering a view of a virtual environment of a video game for display in a head mounted display of a user, wherein the virtual environment includes a plurality of objects. The method including tracking gaze of the user. The method including detecting that the gaze of the user is directed towards an object in the view for a period of time. The method including generating a heads up display (HUD) interface including information related to the object. The method including surfacing the HUD interface near the object in the view of the virtual environment.

Abstract: A disposable absorbent article has a topsheet; a backsheet; an absorbent core disposed between the topsheet and the backsheet; and a first plurality of conforming features in at least the absorbent core or a combination of the absorbent core and the topsheet. At least a portion of the are depressions, wherein the depressions have a depression centerline bisecting a length and/or width of the depression. A first strut forms a first sidewall of the depression opposite a second sidewall of the depression formed by a second strut, wherein neither of the first strut nor the second strut extend longitudinally and/or laterally beyond the depression centerline by more than 0.75 mm.

Abstract: A request is received from a client device over a Virtual Private Network (VPN) tunnel. The request is received at a first one of a plurality of edge servers of a distributed cloud computing network. A destination of the request is determined and an optimized route for transmitting the request toward an origin server is determined. The optimized route is based at least in part on probe data between edge servers of the distributed cloud computing network. The request is transmitted to a next hop as defined by the optimized route.

Abstract: An absorbent has longitudinal and lateral centerlines, first, second, and target regions, the target region being disposed between the first second regions. Each of the first, second target regions extend laterally across the disposable absorbent article. The disposable absorbent article also has a topsheet; a backsheet; an absorbent core disposed between the topsheet and backsheet; a fluid management layer disposed between the topsheet and absorbent core; and a target zone disposed in the target region. The target zone has a first plurality of conforming features in at least the absorbent core or a combination of the absorbent core and at least one of the topsheet or fluid management layer. The absorbent article also has a long fiber network.

Abstract: A disposable absorbent article is described herein. The disposable absorbent article includes a topsheet, a backsheet, and an absorbent system disposed between the topsheet and the backsheet. At least a portion of the has a plurality of conforming features such that the absorbent article has a blot residual value of less than 30 mg and a bending stiffness of less than 12.

Abstract: Traffic optimization in virtual private networks (VPNs) is described. A client device establishes a first VPN connection with a first server according to a first VPN route configuration that specifies a first VPN route to the first server. Flow(s) of traffic is forwarded through the first VPN connection to the first server. The client device receives a second VPN route configuration that specifies a second VPN route to a second server of the plurality of servers for establishing a second VPN connection, where the second VPN connection satisfies a set of traffic optimization criteria. The client device establishes the second VPN connection with the second server according to the second VPN route configuration. Traffic is forwarded through the second VPN connection to the second server.

Abstract: A payment handling system may operate to handle payments for the cost of a transaction in which one or more devices operate in an offline mode. The payment handling system may allow for merchant devices to make modifications to local versions of an open ticket while in an off-line mode. When a merchant device subsequently enters an online mode, the systems and techniques may operate to reconcile differences between the local versions of the open ticket.

Abstract: A disposable absorbent article having a topsheet, a backsheet, and an absorbent core structure disposed between the topsheet and backsheet. The absorbent core structure includes an upper nonwoven layer comprising polymer fibers; a lower nonwoven layer comprising polymer fibers; and an inner core layer disposed between the upper and lower nonwoven layers. The inner core layer may include from about 50% to about 85% cellulosic fibers, by weight of the inner core layer, and from about 15% to about 50% superabsorbent particles, by weight of the inner core layer. The absorbent article may have a CD Dry Bending Stiffness between about 10 N mm2 to about 30 N·mm2 as measured according to the Wet and Dry CD and MD 3 Point Bend Method and a 5th Cycle Wet % Recovery of between about 29% and about 40% as measured according to the Wet and Dry Bunched Compression Method.