Abstract: A cuff seal for sealing the cuffs of anti-contamination protective clothing having cuffs at the distal ends of arms and legs comprises an elongated band that is removably attached to the cuff at an inner end and wraps around the cuff and is attached to the cuff where it overlaps the band at an outer end of the band. The band is fastened to the cuff and to the band itself by spaced pairs of snap fasteners. The band is formed of a stretchable woven fabric which includes an elastomeric yarn in addition to non-elastomeric yarn in order to provide at least a limited stretch capability for the fabric. The band is about two inches wide and covers the arm cuff completely and extends distally beyond the arm cuff so as to provide a snug seal between the band and the wearer's glove at a position distally separated from the cuff. The band similarly encircles the limb of the wearer at the cuff of the coverall legs.