Abstract: Provided herein are antibodies comprising non-natural amino acid residues at site-specific positions, compositions comprising the antibodies, methods of their production and methods of their use. The antibodies are useful for methods of treatment and prevention, methods of detection and methods of diagnosis.

Abstract: Methods and systems of controlling a dual fuel engine with at least two banks of cylinders are provided. The method may include sensing at least one of temperatures of exhaust from the at least two banks and a pressure of an intake manifold of the at least two banks, and adjusting at least one of a gas flow, a charge flow, or an air flow to one of the at least two banks to balance one of exhaust temperatures of the at least two banks and intake manifold pressures of the at least two banks.

Abstract: Methods and systems of controlling a dual fuel engine with at least two banks of cylinders are provided. The method may include sensing at least one of temperatures of exhaust from the at least two banks and a pressure of an intake manifold of the at least two banks, and adjusting at least one of a gas flow, a charge flow, or an air flow to one of the at least two banks to balance one of exhaust temperatures of the at least two banks and intake manifold pressures of the at least two banks.

Abstract: Methods and systems of controlling operation of a dual fuel engine are provided, comprising determining a target exhaust temperature, sensing an actual exhaust temperature, determining an exhaust temperature deviation by comparing the actual exhaust temperature to the target exhaust temperature, comparing the exhaust temperature deviation to a threshold, adjusting at least one of an intake throttle, a wastegate, a compressor bypass valve, an exhaust throttle, a VGT and engine valve timing when the exhaust temperature deviation exceeds the threshold to control charge-flow to the engine, and continuing the adjusting until the exhaust temperature deviation is less than the threshold.

Abstract: Systems and methods for controlling fuelling of dual fuel internal combustion engines are disclosed. The control techniques maximize the substitution rate of gaseous fuel for the liquid fuel by determining a target fuelling amount for the liquid fuel and then regulating an actual fuelling amount of the liquid fuel in response to engine speed and power variations and by modulating the flow rate of the gaseous fuel to the engine.

Abstract: Apparatuses, methods and systems for controlling operation of dual fuel engines are disclosed. One embodiment is a method for controlling operation of a dual fuel engine based upon a combustion index value. The combustion index may be empirically determined to provide desired engine operation at a plurality of ratios of gaseous fuel and liquid fuel. The desired engine operation may include a number of criteria including, for examiner an engine knock criterion and/or an exhaust emissions criterion. The combustion index value may be determined during operation of the engine based upon measured, estimated or predicted engine operating parameters. The combustion index value may be utilized to interpolate between a first engine operating map for a first ratio of gaseous fuel and liquid fuel and a second engine operating map for a second ratio of gaseous fuel and liquid fuel.

Abstract: The present disclosure relates to dual fuel internal combustion engines with multiple cylinder banks and/or cylinder subsets, and exhaust aftertreatment systems associated therewith. Systems and methods are disclosed that relate to engine operations involving fuelling control for fuel cutout of one or more of the cylinder banks and/or cylinder subsets in response to a fuel cutout event to increase gaseous fuel substitution on the other cylinder banks and/or cylinder subsets to satisfy the torque request and thermal management conditions of the aftertreatment system.

Abstract: The present disclosure relates to dual fuel internal combustion engines with multiple cylinder banks and/or cylinder subsets, and exhaust aftertreatment systems associated therewith. Systems and methods are disclosed that relate to engine operations involving fuelling control for fuel cutout of one or more of the cylinder banks and/or cylinder subsets in response to a fuel cutout event to increase gaseous fuel substitution on the other cylinder banks and/or cylinder subsets to satisfy the torque request and thermal management conditions of the aftertreatment system.

Abstract: Methods and systems of controlling operation of a dual fuel engine are provided, comprising determining a target exhaust temperature, sensing an actual exhaust temperature, determining an exhaust temperature deviation by comparing the actual exhaust temperature to the target exhaust temperature, comparing the exhaust temperature deviation to a threshold, adjusting at least one of an intake throttle, a wastegate, a compressor bypass valve, an exhaust throttle, a VGT and engine valve timing when the exhaust temperature deviation exceeds the threshold to control charge-flow to the engine, and continuing the adjusting until the exhaust temperature deviation is less than the threshold.

Abstract: Apparatuses, methods and systems for controlling operation of dual fuel engines are disclosed. One embodiment is a method for controlling operation of a dual fuel engine based upon a combustion index value. The combustion index may be empirically determined to provide desired engine operation at a plurality of ratios of gaseous fuel and liquid fuel. The desired engine operation may include a number of criteria including, for examiner an engine knock criterion and/or an exhaust emissions criterion. The combustion index value may be determined during operation of the engine based upon measured, estimated or predicted engine operating parameters. The combustion index value may be utilized to interpolate between a first engine operating map for a first ratio of gaseous fuel and liquid fuel and a second engine operating map for a second ratio of gaseous fuel and liquid fuel.

Abstract: Systems and methods for controlling fuelling of dual fuel internal combustion engines are disclosed. The control techniques maximize the substitution rate of gaseous fuel for the liquid fuel by determining a target fuelling amount for the liquid fuel and then regulating an actual fuelling amount of the liquid fuel in response to engine speed and power variations and by modulating the flow rate of the gaseous fuel to the engine.

Abstract: Electronic display systems include mobile units for remotely modifying a displayed image. An electronic display system can include a display surface, a processing device, a mobile unit, and an input device. The display surface can receive and display an image rendered by the processing device. The display image on the display surface can be modified through interaction of the input device and the mobile unit. The input device can sense its position relative to the mobile unit and can transmit data relating to its position to the processing device. The processing device can interpret the position data as operations on the displayed image. Accordingly, the processing device can modify the displayed image on the display surface based on interactions between the input device and the mobile unit.