Abstract: Nucleic acids encoding C1 inhibitor are described. Also described are expression cassettes, vectors, cells, and cell lines containing the nucleic acids, as well as methods of using the nucleic acids to treat complement-mediated disorders, such as hereditary angioedema.

Abstract: The present invention refers to a plant or plant part comprising a polynucleotide encoding an herbicide tolerant IAA2 polypeptide having a deleted or disrupted degron tail region, the expression of said polynucleotide confers to the plant or plant part tolerance to synthetic auxin herbicides, such as 2,4-D. The present invention relates to methods and plants and that have a deleted or disrupted degron tail region of the IAA2 protein obtained by gene editing, transformation, mutagenesis, breeding, and the like.

Abstract: A frame assembly for mounting a test fixture includes a plurality of mounting feet configured to attach to a floorboard of a vehicle and a frame body coupled to the plurality of mounting feet. The frame body includes first and second side frame members spaced laterally apart from each other, and at least one cross frame member that extends between the first and second side frame members. The frame assembly further includes an actuator mounting assembly coupled to the frame body for coupling to the test fixture, and a sensor mounting arm coupled to the actuator mounting assembly. The sensor mounting arm extends from a first end coupled to the actuator mounting assembly, away from the frame body, to a second, free end configured for attachment to a position sensor.

Abstract: A frame assembly for mounting a test fixture includes a plurality of mounting feet configured to attach to a floorboard of a vehicle and a frame body coupled to the plurality of mounting feet. The frame body includes first and second side frame members spaced laterally apart from each other, and at least one cross frame member that extends between the first and second side frame members. The frame assembly further includes an actuator mounting assembly coupled to the frame body for coupling to the test fixture, and a sensor mounting arm coupled to the actuator mounting assembly. The sensor mounting arm extends from a first end coupled to the actuator mounting assembly, away from the frame body, to a second, free end configured for attachment to a position sensor.

Abstract: The invention provides a powered water sports board (10) which includes a motor (16) and a power supply (18), both of which are mounted inside a cavity (20) formed inside an elongate buoyant body (12) of the powered water sports board, and a propeller (36) which is capable of being driven by the motor (16) and which is housed inside a fin (14) of the elongate buoyant body (12) thereby to shield the propeller.

Abstract: The invention relates to a ceramifying composition for forming a fire resistant ceramic under fire conditions the composition comprising: (i) at least 10% by weight of mineral silicate; (ii) from 8% to 40% by weight of at least one inorganic phosphate that forms a liquid phase at a temperature of no more than 800° C.; and (iii) at least 15% by weight based on the total weight of the composition of a polymer base composition comprising at least 50% by weight of an organic polymer.

Abstract: Novel organisms, including DNA construct host cell combinations, are disclosed. The organisms comprise a transcription unit (e.g. operon) comprising DNA sequences encoding for enzymes which promote the supply of single carbon units for the conversion of dUMP to dTMP. Examples include: dihydrofolate reductase genes e.g. T4 frd; Serine Hydroxymethyltransferase genes e.g. glyA; 3-phosphoglycerate dehydrogenase genes e.g. serA; and THF synthase genes e.g. ADE3. The organisms are used in a biological method of producing thymidine with significantly reduced levels of uridine.

Abstract: The invention provides a powered water sports board (10) which includes a motor (16) and a power supply (18), both of which are mounted inside a cavity (20) formed inside an elongate buoyant body (12) of the powered water sports board, and a propeller (36) which is capable of being driven by the motor (16) and which is housed inside a fin (14) of the elongate buoyant body (12) thereby to shield the propeller.

Abstract: A blasting agent comprised of an ammonium nitrate component and an organic carbonaceous fuel component. The ammonium nitrate component includes ammonium nitrate crystals having a particle size of from about 1 to about 500 microns and further includes one or more crystal habit modifiers.

Abstract: A blasting agent comprised of an ammonium nitrate component and an organic carbonaceous fuel component. The ammonium nitrate component includes ammonium nitrate crystals having a particle size of from about 1 to about 500 microns and further includes one or more crystal habit modifiers.

Abstract: Novel organisms, including DNA construct host cell combinations, are disclosed. The organisms comprise a transcription unit (e.g. operon) comprising DNA sequences encoding for enzymes which promote the supply of single carbon units for the conversion of dUMP to dTMP. Examples include: dihydrofolate reductase genes e.g. T4 frd; Serine Hydroxymethyltransferase genes e.g. glyA; 3-phosphoglycerate dehydrogenase genes e.g. serA; and THF synthase genes e.g. ADE3. The organisms are used in a biological method of producing thymidine with significantly reduced levels of uridine.

Abstract: The invention relates to a ceramifying composition for forming a fire resistant ceramic under fire conditions the composition comprising: (i) at least 10% by weight of mineral silicate; (ii) from 8% to 40% by weight of at least one inorganic phosphate that forms a liquid phase at a temperature of no more than 800° C.; and (iii) at least 15% by weight based on the total weight of the composition of a polymer base composition comprising at least 50% by weight of an organic polymer.

Abstract: A blasting agent comprised of an ammonium nitrate component and an organic carbonaceous fuel component. The ammonium nitrate component includes ammonium nitrate crystals having a particle size of from about 1 to about 500 microns and further includes one or more crystal habit modifiers.

Abstract: A method of producing an ammonium nitrate blasting agent and such an agent. The method comprises the steps of first combining together a crystal habit modifier with an aqueous solution of ammonium nitrate. Using the mixture of the crystal habit modifier and the ammonium nitrate solution, ammonium nitrate crystals are formed having a particle size of about 1 to about 500 microns. The ammonium nitrate crystals are then combined with an organic carbonaceous fuel at a ratio such that the organic carbonaceous fuel is from about 2 to about 10 percent by weight of the blasting agent.

Abstract: The present invention relates to a recombinant herpes simplex virus (HSV) viral vector genome which has substantially lost its transducing properties as a result of a DNA sequence change in the gene coding for Vmw65 protein and also comprises an expressable heterologous gene inserted into a region of the HSV genome which is non-essential for the culture of the virus, the gene being under the control of the immediate early (IE1) gene enhancer of cytomegalovirus (CMV) and to the use of the recombinant HSV genome in therapy and vaccination.

Abstract: A dual cylinder manifold comprising a flexible, high pressure hose member connected between a first and a second interconnector that funnels pressurized air from two cylinders containing pressurized air to a single regulator. In operation, the first interconnector is attached to a first cylinder valve, the second interconnector to the second cylinder valve, and a regulator attached to the second interconnector. The hose member may be removably connected to the interconnectors so that it can be replaced with another hose member if desired. The manifold may also include valve connectors attached to the interconnectors for connecting to the cylinder valves, a valve adaptor for adapting the second interconnector to receive a regulator of differing connecting design where necessary, a valve connector for making the intended regulator compatible with the second interconnector, or combinations thereof.