Abstract: A wearable device may compress the skin of a user when worn, which may affect values determined using sensors of the device. To determine the effect of skin compression on the values, a time-of-flight signal, images, or frames of video data that depict a portion of the body having indentations from wearing the device may be acquired. Characteristics of the images, such as shadows associated with the indentations, may be processed using a machine learning algorithm or mathematical function to determine a depth of various portions of the indentations. Depth data from the time of flight signal may be used to refine or modify these determined depths. The amount of skin compression associated with the indentations may be used to modify signals acquired using sensors, or output a recommendation for a band or other method for securing the device.

Abstract: Provided herein are immunogenic compositions comprising tumor-specific neoantigen long peptides, tumor-specific neoantigen short peptides, and adjuvant, optionally a helper peptide, and optionally a tumor-specific peptide. The disclosure also provides methods of using these immunogenic compositions for treating cancer.

Abstract: Provided herein are pharmaceutical compositions, kits comprising pharmaceutical compositions, methods of treating disease, and methods of making compositions and kits described herein. The pharmaceutical compositions described herein are powdery pharmaceutical compositions. The powdery pharmaceutical compositions herein can contain particles that are encapsulated with multiple layers of material.

Abstract: Disclosed herein is a method, comprising administering to a subject in need thereof an initial immunogenic composition comprising a plurality of tumor-specific neoantigens, each corresponding to a member of a first set of tumor-associated mutations in a subject, and none corresponding to a member of a second set of tumor-associated mutations in the subject; and quantifying each member of the first set of tumor-associated mutations and each member of the second set of tumor-associated mutations in circulating material comprising tumor-associated mutations isolated from the subject at each of multiple time points.

Abstract: An electrical stimulation system includes a sheath that includes conductive points that are operative to facilitate electrical stimulation to a bodily portion of a user. Drive-sense circuits (DSCs) generate electrical stimulation signals based on reference signals and provide those electrical stimulation signals via electrodes to the conductive points of the sheath. The electrical stimulation signal is coupled into respective locations of the bodily portion of the user that are in proximity to or in contact with the conductive points of the sheath. In addition, the DSCs sense, via the conductive points of the sheath and via the electrodes, changes of the electrical stimulation signals based on coupling of them into the respective locations of the bodily portion of the user. The DSCs provide digital signals that are representative of the changes of the electrical stimulation signals to one or more processing modules that includes and/or is coupled to memory.

Abstract: An electrical stimulation system includes a sheath that includes conductive points that are operative to facilitate electrical stimulation to a bodily portion of a user. Drive-sense circuits (DSCs) generate electrical stimulation signals based on reference signals and provide those electrical stimulation signals via electrodes to the conductive points of the sheath. The electrical stimulation signal is coupled into respective locations of the bodily portion of the user that are in proximity to or in contact with the conductive points of the sheath. In addition, the DSCs sense, via the conductive points of the sheath and via the electrodes, changes of the electrical stimulation signals based on coupling of them into the respective locations of the bodily portion of the user. The DSCs provide digital signals that are representative of the changes of the electrical stimulation signals to one or more processing modules that includes and/or is coupled to memory.

Abstract: Provided herein are pharmaceutical compositions, kits comprising pharmaceutical compositions, methods of treating and preventing disease, and methods of making compositions and kits described herein. The pharmaceutical compositions described herein are powdery pharmaceutical compositions. The powdery pharmaceutical compositions described herein can contain cellular material and can be microencapsulated to increase preservation of the cellular material. The powdery pharmaceutical compositions can be administered by numerous methods, such as by inhalation administration or oral administration.

Abstract: A probe microscope comprising a probe array with an array of probes, each probe comprising a cantilever and a probe tip. A lighting system comprises a plurality of light sources. Each light source is configured to output a respective light beam. A lens array comprises an array of lenses. Each source lens is positioned to receive a respective one of the light beams from the lighting system. A collector lens is configured to collect the light beams from the lens array. An objective lens is configured to receive the light beams from the collector lens and focus each light beam onto the cantilever of a respective one of the probes. The lighting system is configured to modulate a power of the light beams to actuate the probes, and the lighting system is configured to modulate the power of some or all of the light beams independently.

Abstract: A method for execution by a touch screen computing device includes obtaining a touch signal associated with a row electrode of a touch screen display that is operable to render frames of data into visible images, where the touch screen display includes rows of electrodes oriented with columns of electrodes. The method further includes spatial filtering the touch signal in a first direction of the row electrode with respect to columns of the electrodes that form intersections with the row electrode to produce first direction touch signal data. The method further includes spatial filtering the touch signal in a second direction of the row electrode with respect to the intersections to produce second direction touch signal data. The method further includes combining the first and second direction touch signal data to produce a filtered touch signal. The method further includes processing the filtered touch signal to determine touch data.

Abstract: A method for execution by a computing device includes determining to implement a noise prediction and cancellation operation for a touch signal associated with a touch sensor. The method continues during a first time period with turning off a transmitter associated with the touch sensor and obtaining a noise sample of noise associated with the touch sensor, wherein after the first time period is over, the transmitter is turned on. The method continues with generating a noise estimate of the noise based on the noise sample. The method continues during a second time period with obtaining a reduced noise touch signal associated with the touch sensor based on the noise estimate and determining touch data representing a touch of the touch screen based on the reduced noise touch signal, wherein the reduced noise touch signal is produced by subtracting the noise estimate from a current sample of the touch signal.

Abstract: Disclosed herein are methods for evaluating the efficacy of an immunogenic composition by monitoring circulating tumor DNA. The disclosure also relates to methods for treating a subject having cancer.

Abstract: Provided herein are pharmaceutical compositions, kits comprising pharmaceutical compositions, methods of treating disease, and methods of making compositions and kits described herein. The pharmaceutical compositions described herein are powdery pharmaceutical compositions. The powdery pharmaceutical compositions may be administered by an inhaler device described herein. The powdery pharmaceutical compositions may be administered by gummies described herein.

Abstract: A method for execution by a touch screen computing device includes obtaining a touch signal associated with a row electrode of a touch screen display that is operable to render frames of data into visible images, where the touch screen display includes rows of electrodes oriented with columns of electrodes. The method further includes spatial filtering the touch signal in a first direction of the row electrode with respect to columns of the electrodes that form intersections with the row electrode to produce first direction touch signal data. The method further includes spatial filtering the touch signal in a second direction of the row electrode with respect to the intersections to produce second direction touch signal data. The method further includes combining the first and second direction touch signal data to produce a filtered touch signal. The method further includes processing the filtered touch signal to determine touch data.

Abstract: Provided herein are pharmaceutical compositions, kits comprising pharmaceutical compositions, methods of treating disease, and methods of making compositions and kits described herein. The pharmaceutical compositions described herein are powdery pharmaceutical compositions. The powdery pharmaceutical compositions may be administered by an inhaler device described herein. The powdery pharmaceutical compositions may be administered by gummies described herein.

Abstract: Provided herein are pharmaceutical compositions, kits comprising pharmaceutical compositions, methods of treating disease, and methods of making compositions and kits described herein. The pharmaceutical compositions described herein are powdery pharmaceutical compositions. The powdery pharmaceutical compositions may be administered by an inhaler device described herein. The powdery pharmaceutical compositions can comprise encapsulated epinephrine or encapsulated insulin.

Abstract: Techniques are described and relate to anisotropic pooling for contextual embedding of a protein sequence. In an example, a system receives a first biological sequence and determines a sequence arrangement that comprises a component of the first biological sequence and a second biological sequence of components. By using an artificial intelligence (AI) model, the system determines a third sequence that comprises a contextual embedding vector corresponding to the component of the first biological sequence. The AI model generates the third sequence based at least in part on the sequence arrangement and by at least using a convolution and anisotropic pooling.

Abstract: A device operative to transfer power and communicate wirelessly includes a drive-sense circuit (DSC), memory that stores operational instructions, and processing module(s). The DSC generates a drive signal based on a reference signal and provides the drive signal to a first coil via a single line and via a resonating capacitor, and simultaneously senses the drive signal via the single line, to facilitate electromagnetic coupling to a second coil to transfer power wirelessly to another device. The DSC also detects electrical characteristic(s) of the drive signal including whether a communication signal is transmitted from another device and generates a digital signal representative thereof.

Abstract: Techniques for automated alignment of image capture of physical ailments are described. A method of automated alignment of image capture of physical ailments includes determining an alignment class of a first image of an object using an alignment classifier executing on a user device, providing alignment instructions based on the alignment class and a reference image associated with the object using at least one machine learning model executing on the user device, obtaining an aligned image of the object after the user device has been repositioned relative to the object based on the alignment instructions, and sending the aligned image to an agent device via a telemedicine service of a provider network.

Abstract: A pacemaker system includes a drive-sense circuit (DSC) operably coupled to a pacemaker lead. The DSC generates a pace signal including electrical impulses based on a reference signal. The DSC provides the pace signal via the pacemaker lead to an electrically responsive portion of a cardiac conductive system of a subject to facilitate cardiac operation of a cardiovascular system of the subject. The DSC senses, via the pacemaker lead, cardiac electrical activity of the cardiovascular system of the subject that is generated in response to the pace signal and electrically coupled into the pacemaker lead and generates a digital signal that is representative of the cardiac electrical activity of the cardiovascular system of the subject that is sensed via the pacemaker lead. The DSC provides digital information to one or more processing modules that includes and/or is coupled to memory and that provide the reference signal to the DSC.

Abstract: A pacemaker system includes a drive-sense circuit (DSC) operably coupled to a pacemaker lead. The DSC generates a pace signal including electrical impulses based on a reference signal. The DSC provides the pace signal via the pacemaker lead to an electrically responsive portion of a cardiac conductive system of a subject to facilitate cardiac operation of a cardiovascular system of the subject. The DSC senses, via the pacemaker lead, cardiac electrical activity of the cardiovascular system of the subject that is generated in response to the pace signal and electrically coupled into the pacemaker lead and generates a digital signal that is representative of the cardiac electrical activity of the cardiovascular system of the subject that is sensed via the pacemaker lead. The DSC provides digital information to one or more processing modules that includes and/or is coupled to memory and that provide the reference signal to the DSC.