Abstract: This disclosure provides ADAM8 modulating peptides, nucleic acids encoding ADAM8 modulating peptides, and methods for using the same to modulate ADAM8 biological activities in vitro and/or in vivo, to inhibit ADAM8 biological activities associated with diseases or disorders in subjects including gene therapy or cell based therapies. Specifically, methods are provided to decrease inflammation, and to inhibit undesirable cellular proliferation, fibrosis, and angiogenesis. In some embodiments, the ADAM8 modulating peptides or nucleic acids encoding them include modifications of one or more amino acids of the human ADAM8 prodomain amino acid sequence, and in some embodiments the ADAM8 modulating peptides include other modifications such as but not limited to the addition of PEG groups.

Abstract: A composite image is generated from a decorative image, a bar code, and one or more filter patterns. The composite image visually approximates the decorative image, yet the composite image is machine-readable by a scanner capable of reading the bar code, and the composite image encodes the same data as the bar code. Filter patterns provide a flexible way to generate the composite image by selectively updating the decorative image. Updates may be applied in only the locations where necessary, and only by the amount necessary, in order for the composite image to be recognized as a bar code. Also, updates may be applied in arbitrary color spaces, including color spaces where brightness can be altered with less impact on human color perception.

Abstract: A composite image is generated from a decorative image, a bar code, and one or more filter patterns. The composite image visually approximates the decorative image, yet the composite is machine-readable by a scanner capable of reading the original bar code, and the composite encodes the same data as the original bar code. Filter patterns provide a flexible way to selectively alter the decorative image. Alterations can be applied only in locations where necessary, and only to the degree necessary, in order for the composite image to be recognized as a bar code. Alterations can also be applied in arbitrary color spaces, including human perceptual color spaces where brightness can be altered with less impact on apparent color.

Abstract: This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g., brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, media and chinensis. Particular modifications of culture conditions (i.e., media composition and operating modes) have been discovered to enhance the yield of various taxanes from cell culture of all species of Taxus. Particularly preferred enhancement agents include silver ion or complex, jasmonic acid (especially the methyl ester), auxin-related growth regulators, and inhibitors of the phenylpropanoid pathway, such as 3,4-methylenedioxy-6-nitrocinnamic acid. These enhancement agents may be used alone or in combination with one another or other yield-enhancing conditions. While the yield of taxanes from plant cell culture of T.

Abstract: This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g., brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, media and chinensis. Particular modifications of culture conditions (i.e., media composition and operating modes) have been discovered to enhance the yield of various taxanes from cell culture of all species of Taxus. Particularly preferred enhancement agents include silver ion or complex, jasmonic acid (especially the methyl ester), auxin-related growth regulators, and inhibitors of the phenylpropanoid pathway, such as 3,4-methylenedioxy-6-nitrocinnamic acid. These enhancement agents may be used alone or in combination with one another or other yield-enhancing conditions. While the yield of taxanes from plant cell culture of T.

Abstract: An indexing system in a computer system may include applications, a capture processor, a queue, a search engine, and a display processor. The indexing system captures events of user interactions with the applications. Events are queued and if indexable, indexed and stored for user access through the search engine. Capture components in the capture processor can include a keyboard capture component that processes user keystrokes to determine events. A display capture component captures event data from windows associated with the applications. Display event data can be captured on a polling schedule or based on state changes of window elements. To determine target applications and window applications of interest application profiles and window profiles can be used.

Abstract: Root organ cultures of the monocot genus Allium were successfully grown in culture medium. In a preferred bioreactor system, the roots themselves can be grown and harvested as a source of various Allium flavors and/or the growing roots can be reacted with various nutrients to produce Allium flavor compounds independent of the root harvesting. The root cultures of the present invention produce quantities of onion and onion-like flavor compounds comparable to those found in onion bulbs.Flavor precursors arThis invention was made in part under NSF Grant No. 85-03183. The U.S. Government has certain rights to this invention.