Abstract: Embodiments of the present disclosure provide functionality for creating a sustainable dynamic reduced-order model (SDROM) for operating a real-world industrial process. The model is based upon a reduced order model (ROM) trained using data obtained from simulations performed using a first-principles model (FPM) of the real-world industrial process. The trained ROM is divided into multiple-input, single-output (MISO) sub-models, which are partitioned into component terms for incorporation of respective gain factors. The SDROM is deployed online to operate the real-world industrial process with one or more optimization objectives and the SDROM is periodically calibrated and validated using historical operation data.

Abstract: Embodiments of the present disclosure provide functionality for creating a sustainable dynamic reduced-order model (SDROM) for operating a real-world industrial process. The model is based upon a reduced order model (ROM) trained using data obtained from simulations performed using a first-principles model (FPM) of the real-world industrial process. The trained ROM is divided into multiple-input, single-output (MISO) sub-models, which are partitioned into component terms for incorporation of respective gain factors. The SDROM is deployed online to operate the real-world industrial process with one or more optimization objectives and the SDROM is periodically calibrated and validated using historical operation data.

Abstract: Computer-implemented methods of characterizing chemical composition of a sample containing crude oil or a petroleum fraction are presented. The methods can include, in a processor, receiving assay data of the sample, and particularly molecular-level data obtained using advanced analytical techniques, and processing this data in view of a model library of compounds, including reconciling compound compositions, to form a characterization of the chemical composition of the sample.

Abstract: Computer-implemented methods of characterizing chemical composition of a sample containing crude oil or a petroleum fraction are presented. The methods can include, in a processor, receiving assay data of the sample, and particularly molecular-level data obtained using advanced analytical techniques, and processing this data in view of a model library of compounds, including reconciling compound compositions, to form a characterization of the chemical composition of the sample.

Abstract: This invention relates to methods for molecular detection, particularly to methods utilizing target-specific molecular probes. In exemplary embodiments, target-specific molecular probes include single-stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) aptamers. In general, the molecular probe may bind with relatively high specificity to a given target. In one aspect, a method for molecular detection comprises a molecular probe paired to a reporter molecule wherein the molecular probe impairs the amplification of the reporter molecule in the absence of the target molecule.

Abstract: This invention relates to methods for molecular detection, particularly to methods utilizing target-specific molecular probes. In exemplary embodiments, target-specific molecular probes include single-stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) aptamers. In general, the molecular probe may bind with relatively high specificity to a given target. In one aspect, a method for molecular detection comprises a molecular probe paired to a reporter molecule wherein the molecular probe impairs the amplification of the reporter molecule in the absence of the target molecule.

Abstract: The present invention is directed to dental prophylaxis devices that improve portability, maneuverability and aid in retaining clean conditions for use on dental patients, particularly to dental handpieces. The present invention is also directed prophylaxis or prophy angles for use with such handpieces. In general, a dental prophylaxis device includes a handpiece and a prophy angle which includes a driven shaft and a prophy cup attached for rotation thereto. The handpiece generally includes a body which houses a rotational source coupled to an output shaft which couples to the driven shaft in the prophy angle via angled gear interfaces on the output shaft and the driven shaft.

Abstract: This invention relates to methods for molecular detection, particularly to methods utilizing target-specific molecular probes. In exemplary embodiments, target-specific molecular probes include single-stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) aptamers. In general, the molecular probe may bind with relatively high specificity to a given target. In one aspect, a method for molecular detection comprises a molecular probe paired to a reporter molecule wherein the molecular probe impairs the amplification of the reporter molecule in the absence of the target molecule.

Abstract: This invention relates to methods for molecular detection, particularly to methods utilizing target-specific molecular probes. In exemplary embodiments, target-specific molecular probes include single-stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) aptamers. In general, the molecular probe may bind with relatively high specificity to a given target. In one aspect, a method for molecular detection comprises a molecular probe paired to a reporter molecule wherein the molecular probe impairs the amplification of the reporter molecule in the absence of the target molecule.

Abstract: This invention relates to methods for molecular detection, particularly to methods utilizing target-specific molecular probes. In exemplary embodiments, target-specific molecular probes include single-stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) aptamers. In general, the molecular probe may bind with relatively high specificity to a given target. In one aspect, a method for molecular detection comprises a molecular probe paired to a reporter molecule wherein the molecular probe impairs the amplification of the reporter molecule in the absence of the target molecule.

Abstract: This invention relates to methods for molecular detection, particularly to methods utilizing target-specific molecular probes. In exemplary embodiments, target-specific molecular probes include single-stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) aptamers. In general, the molecular probe may bind with relatively high specificity to a given target. In one aspect, a method for molecular detection comprises a molecular probe paired to a reporter molecule wherein the molecular probe impairs the amplification of the reporter molecule in the absence of the target molecule.

Abstract: The present invention relates to a dental implement such as tongue scraper that is disposable and is adapted for prophylactic and/or therapeutic action for the oral cavity. The dental implement may include a tongue scraper, a dental floss, a toothpick, a toothbrush or combinations thereof. The dental implement may include a strip having a longitudinal dimension that is longer than its traverse dimension. The strip may be coated with a coating of a mixture including at least one medicament and a water soluble or erodible carrier. In one embodiment, the coating may be present on at least one of the longitudinal edges, for example, of a tongue scraper, toothpick or a dental floss. In another embodiment, the coating may be present on at least one of the traverse edges, for example, of a tooth pick or the bristles of a toothbrush. In a further embodiment, the coating may be present on a combination of edges.

Abstract: A dental illumination system includes an adjustable self-supporting frame and a lamp head coupled to the frame. The lamp head includes a housing and a spacer having formations that is adapted to removably mechanically couple the lamp head to a reference device, again having formations, for facilitating illumination of a tooth by a light source contained within the lamp head. The spacer and lamp head may be formed integrally. If formed separately, both the lamp head and the spacer may include formations.

Abstract: The present invention is directed to dental prophylaxis devices that improve portability, maneuverability and aid in retaining clean conditions for use on dental patients, particularly to dental handpieces. The present invention is also directed prophylaxis or prophy angles for use with such handpieces. In general, a dental prophylaxis device includes a handpiece and a prophy angle which includes a driven shaft and a prophy cup attached for rotation thereto. The handpiece generally includes a body which houses a rotational source coupled to an output shaft which couples to the driven shaft in the prophy angle via angled gear interfaces on the output shaft and the driven shaft.

Abstract: In an endodontic procedure, after the working of a root canal by instruments to remove material and shape the walls of the canal, irrigant is supplied to irrigate and clean the canal. A fluid is applied via a tube which is inserted partway down the root canal and a vacuum is supplied via the cannula. Alternately, the fluid may be supplied through the cannula and vacuum through the tube. The tube and cannula may or may not pass through a material created by a standard dental filling material of a composite nature which provides a seal at a position near the top of the coronal opening. The cleaning may be performed using a cannula having a slight taper with one or a series of larger holes near the top and smaller holes near the bottom; or a pair of cannulas of substantially the same diameter and taper, one with one or a series of larger holes near the top, while the other one with one or a series of holes near the bottom of the cannula.

Abstract: A powered dental tool generally includes a tool tip at its distal end, a body at its proximal end and a motion generating mechanism. In one aspect, the dental tool includes a tool tip having a proximal end and a distal end along a generally longitudinal axis and a reciprocating motion generating mechanism. The reciprocating motion generating mechanism may repeatedly move the tool tip generally back and forth by a given displacement generally along the tool tip's longitudinal axis. This displacement generally resembles the action of a hand scaler, i.e., a reciprocating motion along the longitudinal axis of the scaler, which is unlike the vibration of most powered scalers. Such action may be advantageous as it may be more intuitive for the dental professional or hygienist and may provide more effective scaling action. It may further be advantageous for a powered scaler to more closely resemble a hand scaler in form, which is small, portable and untethered.

Abstract: The present invention relates to a method for improving the oral health of a subject by exposing the oral cavity of the subject to a device comprising a light source that emits a therapeutically effective amount of light. The present invention further relates to devices utilized in exposing light to the oral cavity of a subject in the method of the present invention.

Abstract: A dental lamp boom hinge includes a pivot supporting a dental lamp head and a base supporting the pivot where the pivot may be rotated about a substantially vertical axis with respect to the base. The rotational movement between the pivot and the base is damped with a damping device. The damping device in one embodiment is adjustable to provide a variable level of damping.

Abstract: A dental illumination system includes an adjustable self-supporting frame and a lamp head coupled to the frame. The lamp head includes a housing and a spacer having formations that is adapted to removably mechanically couple the lamp head to a reference device, again having formations, for facilitating illumination of a tooth by a light source contained within the lamp head. The spacer and lamp head may be formed integrally. If formed separately, both the lamp head and the spacer may include formations.

Abstract: The present invention relates to ultrasonic dental tools having an integral sheath and at least one light source adapted to utilize the electromagnetic energy already available in the existing ultrasonic dental unit. The handpiece includes a substantially hollow housing having a primary power source that may include a coil. In one aspect, the ultrasonic dental insert includes a sheath. The sheath may be formed such that it may cover at least part of the handpiece housing. In general, the sheath may serve as a barrier such that it may reduce cross-contamination to and from the patient's mouth. During operation, the primary coil of the handpiece may be inductively coupled to an illumination energy coil such that the illumination energy coil may draw energy from the electromagnetic field of the primary coil to power at least one light emitting element.