Abstract: Disclosed herein include antibodies or fragments thereof having specificity to a sarbecovirus spike protein. Also provided are compositions, methods, and kits for using said antibodies or fragments thereof for preventing or treating, for example a coronavirus infection.

Abstract: A system for machining a piston blank to a predetermined profile includes means for rotating a blank at a predetermined speed and means for moving a tool axially with reference to the blank. Digital processing means receives input data defining the required profile (or part only of the profile if the profile is symmetrical). In response to this data, to digital information on a channel corresponding to the instantaneous angular position of the blank, and to digital data on another channel corresponding to the instantaneous axial position of the tool, the processor outputs digital data defining the required position of the tool in the direction perpendicular to the surface of the blank in order to produce the required profile. The actuator control processor outputs a corresponding digital signal which, via a digital-to-analog converter, drives a tool actuator so as to position the tool correspondingly.