Patents by Inventor Christopher R. Loose
Christopher R. Loose has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220072286Abstract: A device for the delivery of an agent to an intestinal site has a backing element, a mucoadhesive element for adhering the device to the intestinal site, and a reservoir comprising the agent. The mucoadhesive element includes a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of passageway(s) extending from the reservoir to the opposing surface for delivery of the agent from the reservoir to the intestinal site, each of the passageway(s) having a minimum diameter greater than 10 microns, the diameter being determined by cryogenic scanning electron microscopy after 30 minutes of hydration at 20° C. in phosphate buffered saline at pH 6.5.Type: ApplicationFiled: November 12, 2021Publication date: March 10, 2022Inventors: Daniel BONNER, Colin Robert GARDNER, Thomas H. JOZEFIAK, Christopher R. LOOSE, David LUCCHINO, Andrew Craig MILLER, Carlo Giovanni TRAVERSO, Ayush VERMA, Arthur J. COURY, Peter TRAN, John JANTZ
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Publication number: 20210236784Abstract: A device for the delivery of an agent to an intestinal site has a backing element, a mucoadhesive element for adhering the device to the intestinal site, and a reservoir comprising the agent. The mucoadhesive element includes a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of passageway(s) extending from the reservoir to the opposing surface for delivery of the agent from the reservoir to the intestinal site, each of the passageway(s) having a minimum diameter greater than 10 microns, the diameter being determined by cryogenic scanning electron microscopy after 30 minutes of hydration at 20° C. in phosphate buffered saline at pH 6.5.Type: ApplicationFiled: April 19, 2021Publication date: August 5, 2021Inventors: Daniel BONNER, Colin Robert GARDNER, Thomas H. JOZEFIAK, Christopher R. LOOSE, David LUCCHINO, Andrew Craig MILLER, Carlo Giovanni TRAVERSO, Ayush VERMA, Arthur J. COURY, Peter TRAN, John JANTZ
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Publication number: 20200384250Abstract: A device for the delivery of an agent to an intestinal site has a backing element, a mucoadhesive element for adhering the device to the intestinal site, and a reservoir comprising the agent. The mucoadhesive element includes a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of passageway(s) extending from the reservoir to the opposing surface for delivery of the agent from the reservoir to the intestinal site, each of the passageway(s) having a minimum diameter greater than 10 microns, the diameter being determined by cryogenic scanning electron microscopy after 30 minutes of hydration at 20° C. in phosphate buffered saline at pH 6.5.Type: ApplicationFiled: July 31, 2020Publication date: December 10, 2020Inventors: Daniel BONNER, Colin Robert GARDNER, Thomas H. JOZEFIAK, Christopher R. LOOSE, David LUCCHINO, Andrew Craig MILLER, Carlo Giovanni TRAVERSO, Ayush VERMA, Arthur J. COURY, Peter TRAN, John JANTZ
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Patent number: 10117974Abstract: A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37° C. in 70 ?g/mL fibrinogen derived from human plasma containing 1.4 ?g/mL I-125 radiolabeled fibrinogen.Type: GrantFiled: November 3, 2014Date of Patent: November 6, 2018Assignee: ARROW INTERNATIONAL, INC.Inventors: Jun Li, Zheng Zhang, Chad C. Huval, Michael A. Bouchard, Christopher R. Loose, Arthur J. Coury
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Publication number: 20180193621Abstract: A device for the delivery of an agent to an intestinal site has a backing element, a mucoadhesive element for adhering the device to the intestinal site, and a reservoir comprising the agent. The mucoadhesive element includes a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of passageway(s) extending from the reservoir to the opposing surface for delivery of the agent from the reservoir to the intestinal site, each of the passageway(s) having a minimum diameter greater than 10 microns, the diameter being determined by cryogenic scanning electron microscopy after 30 minutes of hydration at 20° C. in phosphate buffered saline at pH 6.5.Type: ApplicationFiled: June 28, 2016Publication date: July 12, 2018Inventors: Daniel Bonner, Colin R. Gardner, Thomas H. Jozefiak, Christopher R. Loose, David Lucchino, Andrew Craig Miller, Carlo Giovanni Traverso, Ayush Verma, Arthur J. Coury, Peter Tran, John Jantz
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Patent number: 10016532Abstract: The present invention generally relates to articles of manufacture, such as medical devices, having a non-fouling surface comprising a grafted polymer material. The surface resists the adhesion of biological material.Type: GrantFiled: November 5, 2014Date of Patent: July 10, 2018Assignee: ARROW INTERNATIONAL, INC.Inventors: Zheng Zhang, Jun Li, Chad C. Huval, Michael A. Bouchard, Arthur J. Coury, Christopher R. Loose
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Patent number: 9895469Abstract: Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve coating the substrate to conceal or reduce flaws on or in the surface of the medical device or other article substrate, and thereafter forming a grafted polymer layer on the treated substrate surface.Type: GrantFiled: June 9, 2011Date of Patent: February 20, 2018Assignee: ARROW INTERNATIONAL, INC.Inventors: Karen A. Schultz, Zheng Zhang, Chad C. Huval, Michael A. Bouchard, Christopher R. Loose
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Patent number: 9895470Abstract: Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity.Type: GrantFiled: December 7, 2009Date of Patent: February 20, 2018Assignee: Semprus Biosciences Corp.Inventors: Jun Li, Trevor Squier, Zheng Zhang, Chad Huval, William Shannan O'Shaughnessy, Michael Hencke, Michael Bouchard, Christopher R. Loose
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Patent number: 9795762Abstract: Catheters and a method of preparation thereof, the catheter comprising a catheter body, a juncture hub, extension lines and connectors, the catheter body having a proximal end, a distal end, an exterior surface, a tip region having a length of 10 cm measured from the distal end of the catheter body, and at least two lumen, each of the catheter body lumen having a proximal end, a distal end, a Lumen Aspect Ratio of at least 3:1, and an intraluminal surface, the distal ends of the at least two catheter body lumen being (i) non-coterminus or (ii) laser-cut, the exterior surface of the catheter body in the tip region or the intraluminal surface of the two catheter body lumen comprising a hydrophilic polymer layer having an Average Dry Thickness of at least about 50 nanometers.Type: GrantFiled: December 14, 2012Date of Patent: October 24, 2017Assignee: ARROW INTERNATIONAL, INC.Inventors: Michael Bouchard, Zheng Zhang, Jun Li, Matt Skinner, Laurence Roth, Douglas Weaver, Eric W. Marchese, Robert Reed, Chad Huval, Christopher R. Loose
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Patent number: 9764069Abstract: Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.Type: GrantFiled: October 2, 2013Date of Patent: September 19, 2017Assignee: Semprus BioSciences CorporationInventors: Laurence A. Roth, Zheng Zhang, Chad C. Huval, Michael A. Bouchard, Christopher R. Loose
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Patent number: 9694114Abstract: Catheters and a method of preparation thereof comprising a catheter body and at least one connector. The catheter body has an exterior surface and at least one lumen having an aspect ratio of at least 3:1 and an intraluminal surface comprising a hydrophilic polymer layer thereon, the hydrophilic polymer layer has an average dry thickness of at least about 50 nanometers, wherein the catheter body comprises one or more permeabilization agents and one or more antimicrobial agents.Type: GrantFiled: August 6, 2014Date of Patent: July 4, 2017Assignee: ARROW INTERNATIONAL, INC.Inventors: David Lucchino, Christopher R. Loose
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Publication number: 20160235893Abstract: Catheters and a method of preparation thereof comprising a catheter body and at least one connector. The catheter body has an exterior surface and at least one lumen having an aspect ratio of at least 3:1 and an intraluminal surface comprising a hydrophilic polymer layer thereon, the hydrophilic polymer layer has an average dry thickness of at least about 50 nanometers, wherein the catheter body comprises one or more permeabilization agents and one or more antimicrobial agents.Type: ApplicationFiled: August 6, 2014Publication date: August 18, 2016Inventors: DAVID LUCCHINO, CHRISTOPHER R. LOOSE
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Patent number: 9358326Abstract: Substrates, optionally coated with an undercoating, having grafted thereto one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted to a functionalized substrate, or optionally from an undercoating on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.Type: GrantFiled: November 8, 2012Date of Patent: June 7, 2016Assignee: ARROW INTERNATIONAL, INC.Inventors: Zheng Zhang, Chad Huval, William Shannan O'Shaughnessey, Michael Hencke, Trevor Squier, Jun Li, Michael Bouchard, Christopher R. Loose
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Publication number: 20160146974Abstract: Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described.Type: ApplicationFiled: August 12, 2015Publication date: May 26, 2016Inventors: ZHENG ZHANG, JUN LI, MATT SKINNER, CHRISTOPHER R. LOOSE, ARTHUR J. COURY
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Patent number: 9120119Abstract: Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described.Type: GrantFiled: December 14, 2012Date of Patent: September 1, 2015Assignee: SEMPRUS BIOSCIENCES CORPORATIONInventors: Zheng Zhang, Jun Li, Matt Skinner, Christopher R. Loose, Arthur J. Coury
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Patent number: 9096703Abstract: A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37° C. in 70 ?g/mL fibrinogen derived from human plasma containing 1.4 ?g/mL I-125 radiolabeled fibrinogen.Type: GrantFiled: June 9, 2011Date of Patent: August 4, 2015Assignee: SEMPRUS BIOSCIENCES CORPORATIONInventors: Jun Li, Zheng Zhang, Chad C. Huval, Michael A. Bouchard, Arthur J. Coury, Christopher R. Loose
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Patent number: 9006359Abstract: Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described.Type: GrantFiled: December 14, 2012Date of Patent: April 14, 2015Assignee: Semprus Biosciences CorporationInventors: Zheng Zhang, Karen Ann Schultz, Matt Skinner, Christopher R. Loose
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Patent number: 9004682Abstract: Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described.Type: GrantFiled: December 14, 2012Date of Patent: April 14, 2015Assignee: Semprus Biosciences CorporationInventors: Zheng Zhang, Alonzo Cook, Karen Ann Schultz, Jun Li, Matt Skinner, B. Andre′ Weinstock, Linda M. Guiney, Hao Wang, Christopher R. Loose, Arthur Coury
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Patent number: 9000063Abstract: Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described.Type: GrantFiled: December 14, 2012Date of Patent: April 7, 2015Assignee: Semprus Biosciences CorporationInventors: Zheng Zhang, Alonzo Cook, Karen Ann Schultz, Jun Li, Christopher R. Loose, Arthur Coury
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Publication number: 20150056411Abstract: The present invention generally relates to articles of manufacture, such as medical devices, having a non-fouling surface comprising a grafted polymer material. The surface resists the adhesion of biological material.Type: ApplicationFiled: November 5, 2014Publication date: February 26, 2015Inventors: Zheng ZHANG, Jun LI, Chad C. HUVAL, Michael A. BOUCHARD, Arthur J. COURY, Christopher R. LOOSE