Patents by Inventor Christopher R. Otey

Christopher R. Otey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Libraries of optimized cytochrome P450 enzymes and the optimized P450 enzymes
    Patent number: 8603949
    Abstract: The present disclosure teaches that the recombination of homologous sequences of P450 enzymes, with the aid of SCHEMA to predict a resulting protein structure, is able to generate libraries of chimeras with significant functional diversity. Additionally, the members of these libraries demonstrate superior or unexpected new properties, which correlate with other factors that are observable in the library. Thus, the making of libraries of optimized P450 enzymes, the analysis of libraries to identify an optimized subset, and the optimized chimeras with improved or altered functionalities are all taught in the present disclosure.
    Type: Grant
    Filed: June 15, 2004
    Date of Patent: December 10, 2013
    Assignee: California Institute of Technology
    Inventors: Frances H. Arnold, Christopher R. Otey