Abstract: Assays and methods for detecting resistance to beta-lactam antibiotics including detection of multiple ?-lactamase family specific gene targets by polymerase chain reaction or microarray. One or more kits including primers and/or probes for identification of ?-lactamase genes selected from the group consisting of one or more of the following: MOX-like, FOX-like, ACC-like, ACT/MIR-like, CMY-2-like, DHA-like, CTX-M-14-like, CTX-M-15-like, VIM-like, NDM-like, IMP-like, KPC-like, and OXA-48-like, OXA-51-like, OXA-143-like, OXA-58-like, OXA-23-like, OXA-24/40-like, TEM-like, and SHV-like. A kit may also include one or more primers and/or probes for the identification a non-beta lactamase gene family which confers antibiotic resistance, such as the MCR-1 gene.

Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

Abstract: An arrangement for the control of viewing of a television programme in which a classification code is transmitted with the video signal, for example in an extension packet of a teletext signal, includes a decoder (23) which detects the received codes and passes them to a microcontroller (27). An authorised user is able to enter codes of permitted programme classifications by means of a remote control unit (28). Codes representing these permitted classifications are stored in a non-volatile memory (29). The received and permitted codes are compared in the micro controller (27) that inhibits the video (25) and/or audio (32) circuits if the received codes are not permitted codes. A second tuner 40 is provided which is controlled by the processor (27) to cycle through the available channels and for each channel the processor determines the classification codes being transmitted and notes those channels which have non-permitted (or permitted) classification codes.