Abstract: A wind turbine blade mold system having built in precision pins to locate structural components (e.g. spar caps) during layup of composite segments. A plurality of pins can be inserted through the layers of composite layups and into apertures within the mold, with spar caps positioned against the pins to ensure precise positioning, thereby preventing/inhibiting movement of the spar cap relative to the mold. A plurality of pins can be inserted through the layers of composite layups and into apertures within the mold, with cams attached to the pins and moveable to engage spar caps to ensure precise positioning of the spar cap, as well as preventing any drift during subsequent operations. The pins can remain embedded within the final molded part.

Abstract: A method for fabrication of a wind turbine blade includes providing a plug to define a mold, the plug including at least one female surface feature formed therein. Forming a mold, the mold configured for forming a wind turbine blade surface and having a male surface feature(s) corresponding to the at least one female surface feature of the plug. Forming a wind turbine blade surface within the mold, the wind turbine blade surface having a female surface feature(s) corresponding to the male surface feature(s) of the mold. Incorporating at least one optical marker within the female surface feature of the wind turbine blade surface. Providing predetermined optical marker location(s) associated with the wind turbine blade surface. Projecting at least one optical beam directed towards at least one optical marker.

Abstract: A method for fabrication of a wind turbine blade includes providing a plug to define a mold, the plug including at least one female surface feature formed therein. Forming a mold, the mold configured for forming a wind turbine blade surface and having a male surface feature(s) corresponding to the at least one female surface feature of the plug. Forming a wind turbine blade surface within the mold, the wind turbine blade surface having a female surface feature(s) corresponding to the male surface feature(s) of the mold. Incorporating at least one optical marker within the female surface feature of the wind turbine blade surface. Providing predetermined optical marker location(s) associated with the wind turbine blade surface. Projecting at least one optical beam directed towards at least one optical marker.

Abstract: Provided herein is a wind turbine blade mold system having built in precision pins to locate structural components (e.g. spar caps) during layup of composite segments. A plurality of pins can be inserted into apertures within the mold, with discs attached to the pins to maintain fixed relative distance to spar caps positioned relative to the pins to ensure precise positioning, thereby preventing/inhibiting movement of the spar cap relative to the mold. The pins can include a first extension that pierce through the layers of composite layups, and protrude above the B-surface of the blade skin. Additionally, the pins can include a marker tip releasably attached to the pin top to provide visual identification of the pin and underlying structural components. The pins can remain embedded within the final molded part.

Abstract: A wind turbine blade mold system having built in precision pins to locate structural components (e.g. spar caps) during layup of composite segments. A plurality of pins can be inserted through the layers of composite layups and into apertures within the mold, with spar caps positioned against the pins to ensure precise positioning, thereby preventing/inhibiting movement of the spar cap relative to the mold. A plurality of pins can be inserted through the layers of composite layups and into apertures within the mold, with cams attached to the pins and moveable to engage spar caps to ensure precise positioning of the spar cap, as well as preventing any drift during subsequent operations. The pins can remain embedded within the final molded part.

Abstract: Devices, systems, and methods of improving paste flow during the manufacture of wind turbine blades are provided. When the first turbine blade half is aligned with the second turbine blade half, a gap is formed between the first shell and the bond cap. The assembly includes a first mold half corresponding to the first turbine blade half and a second mold half corresponding to the second turbine blade half. When the first mold is aligned with the second mold, a second gap is formed. A first barrier is disposed within the first gap and a second barrier disposed within the second gap thereby fluidly sealing a volume defined by the first gap and the second gap to direct adhesive paste flow along the blade span between the adjoining leading and trailing edges.

Abstract: Provided herein is a wind turbine blade mold system having built in precision pins to locate structural components (e.g. spar caps) during layup of composite segments. A plurality of pins can be inserted through the layers of composite layups and into apertures within the mold, with spar caps positioned against the pins to ensure precise positioning, thereby preventing/inhibiting movement of the spar cap relative to the mold. A plurality of pins can be inserted through the layers of composite layups and into apertures within the mold, with cams attached to the pins and moveable to engage spar caps to ensure precise positioning of the spar cap, as well as preventing any drift during subsequent operations. The pins can remain embedded within the final molded part.

Abstract: Provided herein is a wind turbine blade mold system having built in precision pins to locate structural components (e.g. spar caps) during layup of composite segments. A plurality of pins can be inserted into apertures within the mold, with discs attached to the pins to maintain fixed relative distance to spar caps positioned relative to the pins to ensure precise positioning, thereby preventing/inhibiting movement of the spar cap relative to the mold. The pins can include a first extension that pierce through the layers of composite layups, and protrude above the B-surface of the blade skin. Additionally, the pins can include a marker tip releasably attached to the pin top to provide visual identification of the pin and underlying structural components. The pins can remain embedded within the final molded part.

Abstract: A method for fabrication of a wind turbine blade includes providing a plug to define a mold, the plug including at least one female surface feature formed therein. Forming a mold, the mold configured for forming a wind turbine blade surface and having a male surface feature(s) corresponding to the at least one female surface feature of the plug. Forming a wind turbine blade surface within the mold, the wind turbine blade surface having a female surface feature(s) corresponding to the male surface feature(s) of the mold. Incorporating at least one optical marker within the female surface feature of the wind turbine blade surface. Providing predetermined optical marker location(s) associated with the wind turbine blade surface. Projecting at least one optical beam directed towards at least one optical marker.

Abstract: The invention relates to generation, optimization and characterisation of VHH targeted against Tau MTBD (microtubule-binding domain) with high affinity, obtained by screening from a naïve synthetic library. The inventors optimized version of a lead VHH which is able to inhibit Tau aggregation in vitro and in HEK 293 aggregation-reporting cellular model, providing a new tool in Tau immunotherapies. Accordingly the invention relates to new VHH antibody that specifically binds with high affinity Tau species, especially the epitope region involved in Tau aggregation. Moreover, the inventors found that immunization with the optimized version of this lead VHH prevented the formation of neurofibrillary tangles induced by injection of extracellular h-AD in mouse model. Thus, these specific antibodies can be used for the therapy of tauopathy disorders such as Progressive supranuclear palsy (PSP).

Abstract: Provided herein is a wind turbine blade mold system having built in precision pins to locate structural components (e.g. spar caps) during layup of composite segments. A plurality of pins can be inserted through the layers of composite layups and into apertures within the mold, with spar caps positioned against the pins to ensure precise positioning, thereby preventing/inhibiting movement of the spar cap relative to the mold. A plurality of pins can be inserted through the layers of composite layups and into apertures within the mold, with cams attached to the pins and moveable to engage spar caps to ensure precise positioning of the spar cap, as well as preventing any drift during subsequent operations. The pins can remain embedded within the final molded part.

Abstract: Devices, systems, and methods of improving paste flow during the manufacture of wind turbine blades are provided. When the first turbine blade half is aligned with the second turbine blade half, a gap is formed between the first shell and the bond cap. The assembly includes a first mold half corresponding to the first turbine blade half and a second mold half corresponding to the second turbine blade half. When the first mold is aligned with the second mold, a second gap is formed. A first barrier is disposed within the first gap and a second barrier disposed within the second gap thereby fluidly sealing a volume defined by the first gap and the second gap to direct adhesive paste flow along the blade span between the adjoining leading and trailing edges.

Abstract: The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use.

Abstract: A chainable dunnage supply material, such as a roll of paper, for creating an extended or continuous supply of material, by chaining multiple units together. The dunnage supply arrangement comprises a first supply unit of an elongated web of material in a high-density arrangement, where the material may be converted into a low-density dunnage. The material has first and second longitudinal ends, and a connecting member is disposed adjacent to the first longitudinal end. The connecting member may include an adhesive surface for adhering to a longitudinal second end of a second supply unit of material with sufficient adhesion for pulling the material of the second supply unit into the dunnage mechanism (e.g. daisy chaining the two supply units together). The arrangement may include a release layer on the adhesive surface of the connecting member and releasable therefrom for allowing the connecting member to adhere to a second supply unit.

Abstract: The present invention relates to protein-protein interactions involved in AIDS. More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies to the complexes, Selected Interacting Domains (SID®) which are identified due to the protein-protein interactions, methods for screening drugs for agents which modulate the interaction of proteins and pharmaceutical compositions that are capable of modulating the protein-protein interactions.

Abstract: The invention relates to a method of screening and identifying modulators of the protein interaction between new peptides and anti-apoptotic members of the Bcl-2 protein family. The modulators identified on the basis of this method are administered to patients with cancer in order to bring about apoptotic-type and/or autophagic-type programmed cell death in those patients.

Abstract: The invention relates to a method of identifying modulators of programmed cell death, comprising an interaction between a motif of Beclin protein and an anti-apoptotic member of the family of Bcl-2 proteins and the detection of said interaction be means of fluorescence polarization. The modulators identified on the basis of said method are administered to cancer patients in order to induce apoptotic- and/or autophagic-type programmed cell death. The invention also relates to a motif of the Beclin protein which can interact with an anti-apoptic member of the family of Bcl-2 proteins and to the use thereof in order to induce programmed cell death in a cancer patient.

Abstract: The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use wherein R3, R4, R5, R6, Y, Het1, T, U, V, W, X, Ru, Rv and Rw are as defined in claim 1.

Abstract: The present invention relates to protein-protein interactions involved in AIDS. More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies to the complexes, Selected Interacting Domains (SID®) which are identified due to the protein-protein interactions, methods for screening drugs for agents which modulate the interaction of proteins and pharmaceutical compositions that are capable of modulating the protein-protein interactions.

Abstract: The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use: Formula (I) wherein R3, R4, R5, R6, Y, Het1, T, U, V, W, X, Ru, Rv and Rw are as defined in claim 1