Abstract: A method of quantifying the effect of peripheral optical errors on driving includes displaying, on a central portion of a display, a visual representation of a vehicle on a dynamic roadway; intermittently displaying a curve in the dynamic roadway; intermittently displaying, on a peripheral portion of the display, a target object; receiving a signal in response to a participant viewing the target object; determining a reaction time and determining target detection accuracy. Another method includes displaying a participant vehicle and a lead vehicle in front of the participant vehicle on a roadway; signaling an alert when the participant vehicle is outside of a distance range to the lead vehicle; intermittently displaying, on a peripheral portion of the display, a target object; receiving a signal in response to a participant detecting the target; and quantifying the effect of the peripheral optical errors based on reaction time and target detection accuracy.

Abstract: A method of quantifying the effect of peripheral optical errors on patient locomotion includes projecting a pattern on the floor that includes a discrete shapes and empty spaces between the discrete shapes. The method also includes tracking a position of the participant along the pattern as the participant traverses the pattern, and determining foot placement accuracy, utilizing a optical motion capture system and a computer, as the participant walked through the pattern by determining a total area of overlap between the participant's feet and the empty spaces of the pattern. In another embodiment, the method includes arranging obstacles in front of a participant, intermittently displaying a character in front of the participant, determining participant's accuracy in identifying or counting the characters, and determining the participant's step length and foot clearance as the participant steps over the obstacles to quantify the effect of the peripheral optical errors on the participant's locomotion.

Abstract: The subject matter of this specification can be implemented in, among other things, a method, system, and/or device to receive current metrology data for an operation on a current sample in a fabrication process. The metrology data includes a current value for a parameter at each of one or more locations on the current sample. The method further includes determining a current rate of change of the parameter value for each of the one or more locations. The current rate of change is associated with the current sample. The method further includes identifying one or more violating locations each having an associated current rate of change of the parameter value that is greater than an associated reference rate of change of the parameter value, and identifying an instance of abnormality of the fabrication process based on the one or more violating locations.

Abstract: A method of quantifying the effect of peripheral optical errors on driving includes displaying, on a central portion of a display, a visual representation of a vehicle on a dynamic roadway; intermittently displaying a curve in the dynamic roadway; intermittently displaying, on a peripheral portion of the display, a target object; receiving a signal in response to a participant viewing the target object; determining a reaction time and determining target detection accuracy. Another method includes displaying a participant 10 vehicle and a lead vehicle in front of the participant vehicle on a roadway; signaling an alert when the participant vehicle is outside of a distance range to the lead vehicle; intermittently displaying, on a peripheral portion of the display, a target object; receiving a signal in response to a participant detecting the target; and quantifying the effect of the peripheral optical errors based on reaction time and target detection accuracy.

Abstract: A method of quantifying the effect of peripheral optical errors on patient locomotion includes projecting a pattern on the floor that includes a discrete shapes and empty spaces between the discrete shapes. The method also includes tracking a position of the participant along the pattern as the participant traverses the pattern, and determining foot placement accuracy, utilizing a optical motion capture system and a computer, as the participant walked through the pattern by determining a total area of overlap between the participant's feet and the empty spaces of the pattern. In another embodiment, the method includes arranging obstacles in front of a participant, intermittently displaying a character in front of the participant, determining participant's accuracy in identifying or counting the characters, and determining the participant's step length and foot clearance as the participant steps over the obstacles to quantify the effect of the peripheral optical errors on the participant's locomotion.

Abstract: The subject matter of this specification can be implemented in, among other things, a method, system, and/or device to receive current metrology data for an operation on a current sample in a fabrication process. The metrology data includes a current value for a parameter at each of one or more locations on the current sample. The method further includes determining a current rate of change of the parameter value for each of the one or more locations. The current rate of change is associated with the current sample. The method further includes identifying one or more violating locations each having an associated current rate of change of the parameter value that is greater than an associated reference rate of change of the parameter value, and identifying an instance of abnormality of the fabrication process based on the one or more violating locations.

Abstract: The subject matter of this specification can be implemented in, among other things, a method, system, and/or device to receive current metrology data for an operation on a current sample in a fabrication process. The metrology data includes a current value for a parameter at each of one or more locations on the current sample. The method includes obtaining a reference rate of change of the parameter value of the parameter for each of the one or more locations. The method further includes determining a current rate of change of the parameter value for each of the one or more locations. The current rate of change is associated with the current sample. The method further includes comparing the current rate of change of the parameter value to the reference rate of change of the parameter value and identifying an instance of abnormality of the fabrication process based on the comparison.

Abstract: The subject matter of this specification can be implemented in, among other things, a method, system, and/or device to receive current metrology data for an operation on a current sample in a fabrication process. The metrology data includes a current value for a parameter at each of one or more locations on the current sample. The method includes obtaining a reference rate of change of the parameter value of the parameter for each of the one or more locations. The method further includes determining a current rate of change of the parameter value for each of the one or more locations. The current rate of change is associated with the current sample. The method further includes comparing the current rate of change of the parameter value to the reference rate of change of the parameter value and identifying an instance of abnormality of the fabrication process based on the comparison.

Abstract: A bidirectional filter drier has a generally spherical outer shell having a first opening and a second opening. The shell contains a desiccant core and first and second filter elements. The first filter element is on a first side of the core, adjacent the first opening, and the filter flexible element on a second side of the core adjacent the second opening. The first filter element and the second filter element control flow around and through the core depending on the direction of fluid flow through the filter drier.

Abstract: A bidirectional filter drier has a generally spherical outer shell having a first opening and a second opening. The shell contains a desiccant core and first and second filter elements. The first filter element is on a first side of the core, adjacent the first opening, and the filter flexible element on a second side of the core adjacent the second opening. The first filter element and the second filter element control flow around and through the core depending on the direction of fluid flow through the filter drier.

Abstract: Provided herein are methods, compositions, and kits for simultaneously sequencing polynucleotides from a plurality of samples in a single sequencing run. In an embodiment, the present invention improves efficiency of the next-generation sequencing process, in part, by reducing reaction volumes to a sub-microliter range and generating and using a set of novel barcode sequences to tag a plurality of polynucleotides. In addition, the sample preparation processes have been simplified to save time and cost, while providing high-quality sequence coverage for all samples.

Abstract: An improved process for the manufacture of technical grade (meth)acrylic acid, e.g., acrylic acid, the process comprising producing a hydrated reaction product from the gas-phase oxidation of at least one (meth)acrylic acid precursor, e.g., propylene, followed by first dehydrating and then concentrating the reaction product, the improvement comprising controlling at least one of the water, acetic acid and (meth)acrylic acid content of the reaction product during the purification of the reaction product using on-line, near IR spectroscopy.

Abstract: Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application as pharmaceutical and veterinary products.

Abstract: Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application as pharmaceutical and veterinary products.

Abstract: Domains of jerangolid polyketide synthase and modification enzymes and polynucleotides encoding them are provided. Methods to prepare jerangolid in pharmaceutically useful quantities are described, as are methods to prepare jerangolid analogs and other polyketides using the polynucleotides encoding jerangolid synthase domains or modifying enzymes.

Abstract: Domains of ambruticin polyketide synthase and modification enzymes and polynucleotides encoding them are provided. Methods to prepare ambruticin in pharmaceutically useful quantities are described, as are methods to prepare ambruticin analogs and other polyketides using the polynucleotides encoding ambruticin synthase domains or modifying enzymes.

Abstract: Domains of jerangolid polyketide synthase and modification enzymes and polynucleotides encoding them are provided. Methods to prepare jerangolid in pharmaceutically useful quantities are described, as are methods to prepare jerangolid analogs and other polyketides using the polynucleotides encoding jerangolid synthase domains or modifying enzymes.

Abstract: Polyketide compounds of the formula but not including FK-506, FK-520, 18-hydroxy-FK520 and 18-hydroxy-FK-506.