Abstract: The invention relates to antibodies which bind to insulin like growth factor receptor-1 (IGF-1R) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific human and murine monoclonal antibodies which inhibit IGF-1R-mediated pro-survival and tumor proliferation pathways, and variants, fragments, and derivatives thereof are provided. Also provided are specific human and murine monoclonal antibodies which block the ability of the ligands, insulin like growth factor 1 (IGF-1) and insulin like growth factor 2 (IGF-2) to bind to IGF-1R, as well as fragments, variants and derivatives of such antibodies. The invention also includes polynucleotides encoding the above antibodies or fragments, variants or derivatives thereof, as well as vectors and host cells comprising such polynucleotides. The invention further includes methods of diagnosing and treating cancer using antibodies of the invention.

Abstract: The invention relates to the three-dimensional structure of a crystal of a transporter protein complexed with a ligand. The three-dimensional structure of the transporter-ligand complex is disclosed. The transporter-ligand crystal structure, wherein the ligand is an inhibitor molecule, is useful for providing structural information that may be integrated into drug screening and drug design processes. Thus, the invention also relates to methods for utilizing the crystal structure of the transporter-ligand complex for identifying, designing, selecting, or testing inhibitors of the transporter protein, such inhibitors being useful as therapeutics for the treatment or modulation of i) diseases; ii) disease symptoms; or iii) the effect of other physiological events mediated by the transporter.

Abstract: A folding book support including a main support member having an attachment jaw which flexes to allow it to be affixed to the edge of a flat surface such as a table or desk. A pivoting cross-member is provided to extend the support diameter of the device. The cross-member is folded to a position colinear with the main support member for storage and transport. An optional support leg is provided for use when the edge of a suitable flat surface is not available to affix the holder.

Abstract: A folding book support including a main support member having an attachment jaw which flexes to allow it to be affixed to the edge of a flat surface such as a table or desk. A pivoting cross-member is provided to extend the support diameter of the device. The cross-member is folded to a position colinear with the main support member for storage and transport. An optional support leg is provided f or use when the edge of a suitable flat surface is not available to affix the holder.