Abstract: Tissue expanders and their methods of use.

Abstract: The invention relates to a quick release assembly for a bicycle, wherein the assembly comprises an axle having a first non-cylindrical end portion, a cylindrical central portion, and a second non-cylindrical end portion, wherein a diameter of one of the non-cylindrical end portions is larger than the diameter of the cylindrical central portion. The quick release assembly further comprises an insert having a non-cylindrical outer profile configured to be retained in a non-cylindrical opening and having a cam surface disposed therein, wherein the insert is sized to retain one of the non-cylindrical end portions of the axle therein. The assembly also includes a shaft sized to pass through the axle and having a cam follower on a first end and a handle on a second end, wherein the cam follower is configured to form a locking engagement with the cam surface upon an axial rotation of the handle.

Abstract: A gastric balloon includes a scaffold structure, one or more internal inflatable compartments within the scaffold structure, and one or more inflatable bladders formed over the space-filling compartment. The gastric balloon may be deployed transesophageally using a gastroscope and is inflated in situ, preferably using a combination of liquid and gas inflation media.

Abstract: An electrode catheter is introduced into a vein or other hollow anatomical structure, and is positioned at a treatment: site within the structure. The end of the catheter is positioned near a junction formed in the structure. This junction can be the sapheno-femoral junction. The position of the catheter near the junction is determined based on a signal from a device associated with the catheter within the structure. A fiber optic filament which emits light is used with the catheter or a guide wire over which the catheter is advanced. The light is visible externally from the patient. The light dims and may no longer externally visible at the sapheno-femoral junction where the catheter moves past the deep fascia and toward the deep venous system. The position of the catheter can be determined based on this external observation.

Abstract: Tissue expanders and their methods of use.

Abstract: A catheter includes a first plurality of expandable leads and a second plurality of expandable leads separate and longitudinally spaced-apart from the first plurality to deliver energy to a hollow anatomical structure, such as vein, fallopian tube, hemorrhoid, esophageal varix, to effectively ligate that structure. Each of the leads includes an electrode located at the distal end of the respective electrode lead. Polarizations of the leads may be selected to achieve the power distribution desired. Each electrode lead includes an outward bend such that when a movable sheath is moved out of contact with the leads, they expand outwardly into apposition with an inner wall of the structure to be ligated. High frequency energy can be applied from the leads to create a heating effect in the surrounding tissue of the anatomical structure.

Abstract: The invention relates to a quick release assembly for a bicycle, wherein the assembly comprises an axle having a first non-cylindrical end portion, a cylindrical central portion, and a second non-cylindrical end portion, wherein a diameter of one of the non-cylindrical end portions is larger than the diameter of the cylindrical central portion. The quick release assembly further comprises an insert having a non-cylindrical outer profile configured to be retained in a non-cylindrical opening and having a cam surface disposed therein, wherein the insert is sized to retain one of the non-cylindrical end portions of the axle therein. The assembly also includes a shaft sized to pass through the axle and having a cam follower on a first end and a handle on a second end, wherein the cam follower is configured to form a locking engagement with the cam surface upon an axial rotation of the handle.

Abstract: An electrode catheter is introduced into a vein or other hollow anatomical structure, and is positioned at a treatment site within the structure. The end of the catheter is positioned near a junction formed in the structure. This junction can be the sapheno-femoral junction. The position of the catheter near the junction is determined based on a signal from a device associated with the catheter within the structure. A fiber optic filament which emits light is used with the catheter or a guide wire over which the catheter is advanced. The light is visible externally from the patient. The light dims and may no longer externally visible at the sapheno-femoral junction where the catheter moves past the deep fascia and toward the deep venous system. The position of the catheter can be determined based on this external observation.

Abstract: A gastric balloon includes a scaffold structure, one or more internal inflatable compartments within the scaffold structure, and one or more inflatable bladders formed over the space-filling compartment. The gastric balloon may be deployed transesophageally using a gastroscope and is inflated in situ, preferably using a combination of liquid and gas inflation media.

Abstract: A lever assembly and a master cylinder are provided. The lever assembly includes a lever and an adjuster mechanism that changes the mechanical advantage of the lever. The reach of the lever relative to a handlebar can be adjusted. Both the mechanical advantage and reach of the lever can be adjusted without tools and while a vehicle including the same is operated. The master cylinder includes a reservoir in a clamp area. A reservoir bladder fits into the reservoir. A cover encloses the bladder and includes a vent opening making the bladder at atmospheric pressure such that air can move into the bladder and out of the bladder. The master cylinder can be bled without reorienting the master cylinder. A method of adjusting a mechanical advantage of a lever and a method of bleeding a braking system without reorienting the master cylinder are also provided.

Abstract: A catheter includes a plurality of primary leads to deliver energy for ligating a hollow anatomical structure. Each of the primary leads includes an electrode located at the working end of the catheter. Separation is maintained between the primary leads such that each primary lead can individually receive power of selected polarity. The primary leads are constructed to expand outwardly to place the electrodes into apposition with an anatomical structure. High frequency energy can be applied from the leads to create a heating effect in the surrounding tissue of the anatomical structure. The diameter of the hollow anatomical structure is reduced by the heating effect, and the electrodes of the primary leads are moved closer to one another. Where the hollow anatomical structure is a vein, energy is applied until the diameter of the vein is reduced to the point where the vein is occluded. In one embodiment, a secondary lead is surrounded by the primary leads, and extends beyond the primary leads.

Abstract: A catheter includes a plurality of expandable primary leads to deliver energy to a fallopian tube, a vein such as a hemorrhoid or an esophageal varix, or another hollow anatomical structure requiring ligation or occlusion. Each of the primary leads includes an electrode located at the working end of the catheter. Separation is maintained between the primary leads such that the leads can receive power of selected polarity. The primary leads are constructed to expand outwardly to place the electrodes into apposition with a hollow anatomical structure. High frequency energy can be applied from the leads to create a heating effect in the surrounding tissue of the anatomical structure. The diameter of the hollow anatomical structure is reduced by the heating effect, and the electrodes of the primary leads are moved closer to one another.

Abstract: A catheter includes a first plurality of expandable leads and a second plurality of expandable leads separate and longitudinally spaced-apart from the first plurality to deliver energy to a hollow anatomical structure, such as vein, fallopian tube, hemorrhoid, esophageal varix, to effectively ligate that structure. Each of the leads includes an electrode located at the distal end of the respective electrode lead. Polarizations of the leads may be selected to achieve the power distribution desired. Each electrode lead includes an outward bend such that when a movable sheath is moved out of contact with the leads, they expand outwardly into apposition with an inner wall of the structure to be ligated. High frequency energy can be applied from the leads to create a heating effect in the surrounding tissue of the anatomical structure.

Abstract: The present invention relates to a compound of the Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3A, R3B, R4, R5, X, m, and n are as defined herein. Such novel benzamidazole derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

Abstract: A catheter includes a plurality of primary leads to deliver energy for ligating a hollow anatomical structure. Each of the primary leads includes an electrode located at the working end of the catheter. Separation is maintained between the primary leads such that each primary lead can individually receive power of selected polarity. The primary leads are constructed to expand outwardly to place the electrodes into apposition with an anatomical structure. High frequency energy can be applied from the leads to create a heating effect in the surrounding tissue of the anatomical structure. The diameter of the hollow anatomical structure is reduced by the heating effect, and the electrodes of the primary leads are moved closer to one another. Where the hollow anatomical structure is a vein, energy is applied until the diameter of the vein is reduced to the point where the vein is occluded. In one embodiment, a secondary lead is surrounded by the primary leads, and extends beyond the primary leads.