Abstract: Compounds that inhibit the activity of Signal transducer and activator of transcription 3 (STAT3), or pharmaceutically acceptable salts or prodrugs thereof, and methods of using these compounds to treat cancer and other diseases.

Abstract: This document provides compositions comprising (or consisting essentially of or consisting of) one or more water-soluble oils selected from the group consisting of ethoxylated macadamia oil, ethoxylated olive oil, ethoxylated avocado oil, ethoxylated meadowfoam oil, ethoxylated almond oil, ethoxylated corn oil, ethoxylated soybean oil, ethoxylated jojoba oil, ethoxylated seabuckthorn oil (e.g., fruit, berry, or seed oil), ethoxylated emu oil, ethoxylated mink oil, PEG Glyceryl Dimyristate, PEG Glyceryl Dioleate, PEG Glyceryl Distearate, and PEG Glyceryl Palmitate; and one or more agricultural chemical or biological agents. Methods for making and using the compositions also are provided.

Abstract: This document provides compositions comprising (or consisting essentially of or consisting of) one or more water-soluble oils selected from the group consisting of ethoxylated macadamia oil, ethoxylated olive oil, ethoxylated avocado oil, ethoxylated meadowfoam oil, ethoxylated almond oil, ethoxylated corn oil, ethoxylated soybean oil, ethoxylated jojoba oil, ethoxylated seabuckthorn oil (e.g., fruit, berry, or seed oil), ethoxylated emu oil, ethoxylated mink oil, PEG Glyceryl Dimyristate, PEG Glyceryl Dioleate, PEG Glyceryl Distearate, and PEG Glyceryl Palmitate; and one or more agricultural chemical or biological agents. Methods for making and using the compositions also are provided.

Abstract: This document provides compositions comprising (or consisting essentially of or consisting of) one or more water-soluble oils selected from the group consisting of ethoxylated macadamia oil, ethoxylated olive oil, ethoxylated avocado oil, ethoxylated meadowfoam oil, ethoxylated almond oil, ethoxylated corn oil, ethoxylated soybean oil, ethoxylated jojoba oil, ethoxylated seabuckthorn oil (e.g., fruit, berry, or seed oil), ethoxylated emu oil, ethoxylated mink oil, PEG Glyceryl Dimyristate, PEG Glyceryl Dioleate, PEG Glyceryl Distearate, and PEG Glyceryl Palmitate; and one or more agricultural chemical or biological agents. Methods for making and using the compositions also are provided.

Abstract: The present invention provides compositions and methods for reducing water consumption by plants and for modifying the growth of plants. The present invention further provides methods for preparing bioactive solutions and micro and nano emulsions comprising water-soluble or water-miscible oils and/or non-water-soluble oils, which find use in the methods for reducing water consumption by plants and/or for modifying the growth of plants.

Abstract: An adhesively attached shoe sole product with forward directed grooves to prevent a loss of traction when the foot is moving in a forward direction, the product conforming to the toe and outer perimeter of the shoe sole and being attached by a permanent or temporary adhesive to the existing shoe sole.

Abstract: A steerable surgical suture passer providing single hand operation to selectively direct the operation tip in an upward or downward direction to reduce the degree of collateral tissue damage during the use of the instrument, the suture passer providing a shaped handle for ambidextrous use and defining an inner socket, an integrated inner member defining an upper trigger and lower trigger at a proximal end, a pair of resilient intermediate parallel shaft members and a distal operational tip, the inner member pivotally secured within the inner socket by a single pin and a rigid hollow shaft support tube connected to the handle through which the resilient parallel shaft members are directed, allowing the surgeon to steer the operations tip and required when performing a surgical procedure.

Abstract: A multi-positional dual drill guide for use in orthopedic surgical procedures provides two independent drill guides which are independently, pivotally and removably secured along a pivotal drill guide plate comprising two separate and independent guide plate sections, selectively aligning each of the two drill guides for drilling an intersecting bone channel into a common bone from different locations for the passage of a suture and associated tissue during an orthopedic repair of a joint. The drill guide provide for three dimensional movement of the drill guides to provide a range of drilling angles from nearly zero degrees up to 180-degrees apart and in a three dimensional array, the drill.

Abstract: An adapter attached between a dispenser containing a bone void filler and the head of a cannulated surgical screw allows the cannulated surgical screw to be used as a port to inject bone void filler into a bone void during the course of a surgical repair which would use a surgical screw to attach broken or separated bone fragments providing a more secure bone anchor matrix within which the surgical screw is set.

Abstract: A method for utilizing an adapter attached between a syringe filled with a bone void filler and the head of an inserted cannulated surgical screw during the process of a surgical repair to a bone allows the cannulated surgical screw to be used as a port to inject bone void filler into a bone void in the bone during the surgical repair which would use a surgical screw to attach broken or separated bone fragments, the bone void filler within the bone providing a more secure bone anchor matrix within which the surgical screw is set.

Abstract: An adapter attached between a syringe containing a bone void filler and the head of a cannulated surgical screw allows the cannulated surgical screw to be used as a port to inject bone void filler into a bone void during the course of a surgical repair which would use a surgical screw to attach broken or separated bone fragments providing a more secure bone anchor matrix within which the surgical screw is set.

Abstract: An adapter attached between a dispenser containing a bone void filler and the head of a cannulated surgical screw allows the cannulated surgical screw to be used as a port to inject bone void filler into a bone void during the course of a surgical repair which would use a surgical screw to attach broken or separated bone fragments providing a more secure bone anchor matrix within which the surgical screw is set.

Abstract: A surgical anchor device for the repair of a torn ligament or tendon, primarily the anterior cruciate ligament in the knee, is used to affix the ligament within a femoral bone tunnel in the distal portion of the femur from the intra-articular surface, the device providing a pulley for a suture, wherein a free end of the suture may be pulled away from the device to draw the suture attached to the ligament graft within the femoral bone tunnel securing the ligament graft within the bone tunnel. Installation of the device is provided by insertion of the device through a tibial hole, through the femoral tunnel out of the lateral femoral cortex, pulling the attached sutures simultaneously to flatten the device against the lateral femoral cortex, attaching one end of the suture to the ligament graft and pulling the other end of the suture until the graft is situated properly within the femoral bone tunnel and tying the free end of the suture to retain the graft within the femoral bone tunnel.

Abstract: A cancellous externally threaded pulley anchor for transporting an anterior cruciate ligament graft into the distal femur from the intra-articular surface during a surgical repair of the anterior cruciate ligament. A method using this device eliminates the need to pierce the lateral femoral skin during the surgery and also prevent interference with other surgical instruments and the knee and thigh holder, the anchor providing a pulley for the force insertion of the ligament graft into a femoral bone tunnel after the anchor is installed within the femoral bone tunnel by pulling the unattached end of the suture while the other end of the suture is secured to the ligament graft.

Abstract: A surgical anchor device for the repair of a torn ligament or tendon, primarily the anterior cruciate ligament in the knee, is used to affix the ligament within a femoral bone tunnel in the distal portion of the femur from the intra-articular surface, the device providing a pulley for a suture, wherein a free end of the suture may be pulled away from the device to draw the suture attached to the ligament graft within the femoral bone tunnel securing the ligament graft within the bone tunnel. Installation of the device is provided by insertion of the device through a tibial hole, through the femoral tunnel out of the lateral femoral cortex, pulling the attached sutures simultaneously to flatten the device against the lateral femoral cortex, attaching one end of the suture to the ligament graft and pulling the other end of the suture until the graft is situated properly within the femoral bone tunnel and tying the free end of the suture to retain the graft within the femoral bone tunnel.