Patents by Inventor Christopher S. Lange

Christopher S. Lange has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of assaying sensitivity of cancer stem cells to therapeutic modalities
    Patent number: 9410944
    Abstract: The present invention is directed to methods of measuring the proliferative ability of individual patient cancer stem cells. The present invention provides a method for treating a cancer patient according to an assay of the individual patient's tumor's cancer stem cell sensitivity, by measuring the proliferative ability of cancer stem cells from the patient. By the methods of the present invention it is possible to treat individual cancer stem cells presented in tumor cells. Methods of detecting and enumerating cancer stem cells in hybrid spheroids comprised of fibroblasts and tumor cells are also provided by the present invention. The present invention also contemplates a method for drug and other treatment development, wherein the effects of a drug or combination of drugs or other treatments are determined on the individual patient's cancer stem cells.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: August 9, 2016
    Assignee: The Research Foundation for The State University of New York
    Inventors: Christopher S. Lange, Bozidar Djordjevic, Marvin Z. Rotman
  • METHODS OF ASSAYING SENSITIVITY OF CANCER STEM CELLS TO THERAPEUTIC MODALITIES
    Publication number: 20150132792
    Abstract: The present invention is directed to methods of measuring the proliferative ability of individual patient cancer stem cells. The present invention provides a method for treating a cancer patient according to an assay of the individual patient's tumor's cancer stem cell sensitivity, by measuring the proliferative ability of cancer stem cells from the patient. By the methods of the present invention it is possible to treat individual cancer stem cells presented in tumor cells. Methods of detecting and enumerating cancer stem cells in hybrid spheroids comprised of fibroblasts and tumor cells are also provided by the present invention. The present invention also contemplates a method for drug and other treatment development, wherein the effects of a drug or combination of drugs or other treatments are determined on the individual patient's cancer stem cells.
    Type: Application
    Filed: January 15, 2015
    Publication date: May 14, 2015
    Applicant: The Research Foundation for The State University of New York
    Inventors: Christopher S. Lange, Bozidar Djordjevic, Marvin Z. Rotman
  • Methods of assaying sensitivity of cancer stem cells to therapeutic modalities
    Patent number: 8936938
    Abstract: The present invention is directed to methods of measuring the proliferative ability of individual patient cancer stem cells. The present invention provides a method for treating a cancer patient according to an assay of the individual patient's tumor's cancer stem cell sensitivity, by measuring the proliferative ability of cancer stem cells from the patient. By the methods of the present invention it is possible to treat individual cancer stem cells presented in tumor cells. Methods of detecting and enumerating cancer stem cells in hybrid spheroids comprised of fibroblasts and tumor cells are also provided by the present invention. The present invention also contemplates a method for drug and other treatment development, wherein the effects of a drug or combination of drugs or other treatments are determined on the individual patient's cancer stem cells.
    Type: Grant
    Filed: March 31, 2008
    Date of Patent: January 20, 2015
    Assignee: The Research Foundation of State University of New York
    Inventors: Christopher S. Lange, Bozidar Djordjevic, Marvin Z. Rotman
  • Methods of Assaying Sensitivity of Cancer Stem Cells to Therapeutic Modalities
    Publication number: 20100062481
    Abstract: The present invention is directed to methods of measuring the proliferative ability of individual patient cancer stem cells. The present invention provides a method for treating a cancer patient according to an assay of the individual patient's tumor's cancer stem cell sensitivity, by measuring the proliferative ability of cancer stem cells from the patient. By the methods of the present invention it is possible to treat individual cancer stem cells presented in tumor cells. Methods of detecting and enumerating cancer stem cells in hybrid spheroids comprised of fibroblasts and tumor cells are also provided by the present invention. The present invention also contemplates a method for drug and other treatment development, wherein the effects of a drug or combination of drugs or other treatments are determined on the individual patient's cancer stem cells.
    Type: Application
    Filed: March 31, 2008
    Publication date: March 11, 2010
    Inventors: Christopher S. Lange, Bozidar Djordjevic, Marvin Z. Rotman