Patents by Inventor Christopher S. Theile

Christopher S. Theile has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Extrahepatic delivery
    Patent number: 12005074
    Abstract: One aspect of the present invention relates to a double stranded iRNA agent comprising an antisense strand which is complementary to a target gene; a sense strand which is complementary to said antisense strand; and one or more lipophilic moieties conjugated to one or more internal positions on at least one strand, optionally via a linker or carrier. Another aspect of the invention relates to a method of gene silencing, comprising administering to a cell or a subject in need thereof a therapeutically effective amount of the lipophilic moieties-conjugated double-stranded iRNAs.
    Type: Grant
    Filed: May 3, 2023
    Date of Patent: June 11, 2024
    Assignee: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Jayaprakash K. Nair, Martin Maier, Vasant Jadhav, Stuart Milstein, Kirk Brown, Rubina G. Parmar, Kallanthottathil G. Rajeev, Muthiah Manoharan, Alexander V. Kel'In, Muthusamy Jayaraman, Klaus Charisse, Adam Castoreno, Christopher S. Theile, Kevin Fitzgerald
  • Circular siRNAs
    Publication number: 20230257745
    Abstract: One aspect of the present invention relates to a small circular interfering RNA (sciRNA) comprising a sense strand and an antisense strand, each of said sense and antisense strands comprising at least one nucleic acid modification, optionally wherein the sense strand has a circular or substantially circular structure. Other aspects of the invention relate a pharmaceutical composition and a method for inhibiting the expression of a target gene in a subject using the sciRNA.
    Type: Application
    Filed: July 9, 2021
    Publication date: August 17, 2023
    Inventors: Hartmut JAHNS, Ivan ZLATEV, Muthiah MANOHARAN, Christopher S. THEILE
  • EXTRAHEPATIC DELIVERY
    Publication number: 20230016929
    Abstract: One aspect of the present invention relates to a compound comprising an antisense strand which is complementary to a target gene; a sense strand which is complementary to said antisense strand; and one or more lipophilic monomers, containing one or more lipophilic moieties, conjugated to one or more positions on at least one strand, optionally via a linker or carrier. Another aspect of the invention relates to a method of gene silencing, comprising administering to a cell or a subject in need thereof a therapeutically effective amount of the lipophilic monomer-conjugated compound.
    Type: Application
    Filed: November 6, 2020
    Publication date: January 19, 2023
    Inventors: Jayaprakash K. NAIR, Martin A. MAIER, Juan C. SALINAS, Shigeo MATSUDA, Alexander V. KEL'IN, Scott P. LENTINI, Guo HE, Michelle H. JUNG, Justin M. PIERSON, Muthiah MANOHARAN, Dale C. GUENTHER, Ivan ZLATEV, Christopher S. THEILE, Vasant R. JADHAV, Stuart MILSTEIN, Maja JANAS, Dhrubajyoti DATTA
  • DELIVERY OF OLIGONUCLEOTIDES TO THE STRIATUM
    Publication number: 20220307024
    Abstract: One aspect of the present invention relates to a double stranded iRNA agent comprising an antisense strand which is complementary to a target gene; a sense strand which is complementary to said antisense strand; and one or more lipophilic moieties conjugated to one or more internal positions on at least one strand, optionally via a linker or carrier, which provides for targeting to, and uptake by, tissues and cells of the CNS, and in particular the striatum. Another aspect of the invention relates to a method of gene silencing in tissues and cells of the CNS, and in particular the striatum, that includes administering to a tissue/cell or a subject in need thereof a therapeutically effective amount of the lipophilic moieties-conjugated double-stranded iRNAs.
    Type: Application
    Filed: June 16, 2020
    Publication date: September 29, 2022
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Jayaprakash K. Nair, Martin Maier, Vasant Jadhav, Stuart Milstein, Kirk Brown, Rubina G. Parmar, Kallanthottathil G. Rajeev, Muthiah Manoharan, Alexander V. Kel'in, Muthusamy Jayaraman, Klaus Charisse, Adam Castoreno, Christopher S. Theile, Kevin Fitzgerald
  • ENDOSOMAL CLEAVABLE LINKERS
    Publication number: 20220177885
    Abstract: The present disclosure relates generally to cleavable linkers and uses thereof.
    Type: Application
    Filed: February 10, 2022
    Publication date: June 9, 2022
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Jayaprakash K. NAIR, Kallanthottathil G. RAJEEV, Scott LENTINI, Christopher S. THEILE, Martin MAIER, Ivan ZLATEV
  • EXTRAHEPATIC DELIVERY
    Publication number: 20220125823
    Abstract: The invention relates to a method of gene silencing, comprising administering to a cell or a subject in need thereof a therapeutically effective amount of the lipophilic moieties-conjugated double-stranded iRNAs at one or more internal positions on at least one strand, optionally via a linker or carrier.
    Type: Application
    Filed: May 7, 2019
    Publication date: April 28, 2022
    Inventors: Jayaprakash K. NAIR, Martin MAIER, Vasant JADHAV, Stuart MILSTEIN, Kirk BROWN, Rubina G. PARMAR, Kallanthottathil G. RAJEEV, Muthiah MANOHARAN, Alexander V. KEL'IN, Muthusamy JAYARAMAN, Klaus CHARISSE, Adam CASTORENO, Christopher S. THEILE, Kevin FITZGERALD
  • Endosomal cleavable linkers
    Patent number: 11286482
    Abstract: The present disclosure relates generally to cleavable linkers and uses thereof.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: March 29, 2022
    Assignee: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Jayaprakash K. Nair, Kallanthottathil G. Rajeev, Scott Lentini, Christopher S. Theile, Martin Maier, Ivan Zlatev