Abstract: Disclosed herein are methods for selecting tumor-specific neoantigens from a tumor of a subject that are suitable for subject-specific immunogenic compositions.

Abstract: A cloud computing environment receives a request from a client. The request relates to access of an application executing in the cloud computing environment and it encapsulates a certificate. This certificate is then translated into an authorization graph descriptor which, in turn, is used to traverse a certificate authorization graph to identify a match within a certificate repository. In response to the identification of the match, an access token is requested including the authorization graph descriptor. The access token is then encapsulated in the request which is then forwarded to an authentication service which provides access to the application if there is a match of the authorization graph descriptor against pre-defined authorization requirements. Related apparatus, systems, techniques and articles are also described.

Abstract: A cloud computing environment receives a request from a client. The request relates to access of an application executing in the cloud computing environment and it encapsulates a certificate. This certificate is then translated into an authorization graph descriptor which, in turn, is used to traverse a certificate authorization graph to identify a match within a certificate repository. In response to the identification of the match, an access token is requested including the authorization graph descriptor. The access token is then encapsulated in the request which is then forwarded to an authentication service which provides access to the application if there is a match of the authorization graph descriptor against pre-defined authorization requirements. Related apparatus, systems, techniques and articles are also described.

Abstract: This application discloses a computing system implementing a management system to generate a presentation populated with a portion of a meta model in response to a meta model access request for a first client device. The presentation includes one or more editable fields capable of data entry by the first client device. The management system receives an indication that the first client device utilized at least one of the editable fields of the presentation to initiate a modification to the portion of the meta model, and locks a second client device from modifying the portion of the meta model. When the first client device completes the modification to the portion of the meta model, the management system updates the portion of the meta model based on the modification to the portion of the meta model and unlocks the second client device from modifying the portion of the meta model.