Abstract: The invention relates to methods for treating prostate cancer by targeting the generation of splice variants of the androgen receptor. In one aspect, this can be achieved by targeting JMJD6 to reduce the production of androgen receptor splice variants. The invention finds particular use in the treatment of prostate cancer that is resistant to conventional androgen therapy.

Abstract: An electric pushback vehicle includes a frame having a forward portion and a rear portion. The vehicle further includes front drive axle and a rear drive axle configured to communicate power to ground engaging members. A traction battery is housed within the electric pushback vehicle and provides electric power to an electric motor to drive an output shaft. A transmission is connected to receive mechanical power from the electric motor through a torque converter.

Abstract: A method for operating a laboratory system comprising instruments for processing samples and a control unit connected by a communication network is presented. The method comprises receiving and identifying a biological sample and retrieving an order list from a database. The list comprises a plurality of targets defining one or more processing steps to be carried out on the biological sample by one or more of the laboratory instruments. The method also comprises selecting a workflow strategy and retrieving workflow acceptance criterion corresponding to the workflow strategy. The control unit determines a sample workflow for processing the sample based on the workflow strategy and determines whether the sample workflow satisfies the workflow acceptance criterion. If the sample workflow does not satisfy the workflow acceptance criterion, workflow strategy and the workflow acceptance criterion is refined and the sample workflow is determined again until it satisfies the workflow acceptance criterion.

Abstract: A method for simulating an in-vitro diagnostic IVD laboratory system (10) comprising an IVD laboratory instrumentation (2) and an IVD laboratory control software module (3) is proposed, together with a respective system (1) and various application thereof. The proposed method comprises: simulating sample processing within the IVD laboratory instrumentation (2) using a virtual IVD laboratory instrumentation (5) using sample processing data (SPD) provided by the IVD laboratory control software module (3), operating the IVD laboratory control software module (3) as if it was operating within the IVD laboratory system (10) but wherein sample processing data (SPD) intended for being exchanged between the IVD laboratory control software module (3) and the IVD laboratory instrumentation (2) is instead exchanged between the IVD laboratory control software module (3) and the virtual IVD laboratory instrumentation (5).

Abstract: A method for operating a laboratory system comprising instruments for processing samples and a control unit connected by a communication network is presented. The method comprises receiving and identifying a biological sample and retrieving an order list from a database. The list comprises a plurality of targets defining one or more processing steps to be carried out on the biological sample by one or more of the laboratory instruments. The method also comprises selecting a workflow strategy and retrieving workflow acceptance criterion corresponding to the workflow strategy. The control unit determines a sample workflow for processing the sample based on the workflow strategy and determines whether the sample workflow satisfies the workflow acceptance criterion. If the sample workflow does not satisfy the workflow acceptance criterion, workflow strategy and the workflow acceptance criterion is refined and the sample workflow is determined again until it satisfies the workflow acceptance criterion.

Abstract: A method for operating a laboratory system comprising instruments for processing samples and a control unit connected by a communication network is presented. The method comprises receiving and identifying a biological sample and retrieving an order list from a database. The list comprises a plurality of targets defining one or more processing steps to be carried out on the biological sample by one or more of the laboratory instruments. The method also comprises selecting a workflow strategy and retrieving workflow acceptance criterion corresponding to the workflow strategy. The control unit determines a sample workflow for processing the sample based on the workflow strategy and determines whether the sample workflow satisfies the workflow acceptance criterion. If the sample workflow does not satisfy the workflow acceptance criterion, workflow strategy and the workflow acceptance criterion is refined and the sample workflow is determined again until it satisfies the workflow acceptance criterion.

Abstract: A method of operating an analytical laboratory is disclosed. The method comprises receiving and identifying sample containers and sorting them into a sample rack, retrieving an order list A comprising test orders corresponding to the sample containers within the sample rack, determining an optimal transportation route for the sample rack based on the order list A, a set of constraints and an objective function, the optimal transportation route being indicative of a list and/or sequence of laboratory instrument(s) required to complete the order list A, re-determining the optimal transportation route upon a change of the constraint(s) and/or of the objective function, transporting the sample rack to one or more of the laboratory instruments according to the optimal transportation route by the sample transportation system, and processing the biological samples according to the corresponding test orders by the target laboratory instrument(s).

Abstract: A method for operating a laboratory system comprising instruments for processing samples and a control unit connected by a communication network is presented. The method comprises receiving and identifying a biological sample and retrieving an order list from a database. The list comprises a plurality of targets defining one or more processing steps to be carried out on the biological sample by one or more of the laboratory instruments. The method also comprises selecting a workflow strategy and retrieving workflow acceptance criterion corresponding to the workflow strategy. The control unit determines a sample workflow for processing the sample based on the workflow strategy and determines whether the sample workflow satisfies the workflow acceptance criterion. If the sample workflow does not satisfy the workflow acceptance criterion, workflow strategy and the workflow acceptance criterion is refined and the sample workflow is determined again until it satisfies the workflow acceptance criterion.

Abstract: Computer-implemented method for providing access control to a function of an analyzer is presented. A user's log-in data is received from a first data entry terminal. Information descriptive of a position of the first data entry terminal is obtained. It is determined whether the position of the first data entry terminal is within a physical operating (PO) area of the analyzer. A user activatable position sensitive (PS) GUI element is displayed on the first data entry terminal if the position of the first data entry terminal is determined to be within the PO area. The activatable PS GUI element triggers, upon activation, the execution of the function. The execution of the function comprises the execution of a physical action by the analyzer. The display of the user activatable PS GUI element is otherwise prohibited or a non-activatable PS GUI element indicative of the function is displayed.

Abstract: Computer-implemented method for providing access control to a function of an analyzer is presented. A user's log-in data is received from a first data entry terminal. Information descriptive of a position of the first data entry terminal is obtained. It is determined whether the position of the first data entry terminal is within a physical operating (PO) area of the analyzer. A user activatable position sensitive (PS) GUI element is displayed on the first data entry terminal if the position of the first data entry terminal is determined to be within the PO area. The activatable PS GUI element triggers, upon activation, the execution of the function. The execution of the function comprises the execution of a physical action by the analyzer. The display of the user activatable PS GUI element is otherwise prohibited or a non-activatable PS GUI element indicative of the function is displayed.

Abstract: A method is provided for applying a reactive thiol containing coating to a substrate. The method includes subjecting the substrate to a plasma discharge in the presence of a compound of formula (I) or formula (Ia): where X is an optionally substituted straight or branched alkylene chain(s) or aryl group(s); R1, R2 or R3 are optionally substituted hydrocarbyl or heterocyclic groups, and m is an integer greater than 0; Rn is a number of optionally substituted hydrocarbyl or heterocyclic groups, where n is 0-5.

Abstract: The present invention relates to a process for the preparation of a pyrrolidone compound of the formula (I): where R1 is substituted or unsubstituted alkyl, alkenyl, or alkynyl, or an aromatic or non-aromatic cyclic or heterocyclic structure, R2 is substituted or unsubstituted alkyl or cycloalkyl, and each P is independently a protecting group.

Abstract: A method of identifying, screening, characterising or designing a chemical entity, which mimics or binds to FIH, is described. The method comprises comparing a structural model of FIH with a structural model for said chemical entity, wherein said structural model of FIH is derived from structural factors or structural coordinates determined by subjecting to X-ray diffraction measurements a crystal comprising FIH. Such chemical entities may be used in the treatment of a condition associated with increased or decreased HIF levels or activity.

Abstract: A pharmaceutical composition comprising a compound of formula (I) wherein X is an electron withdrawing group, Y1 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, —SO2R4, —CO2R4, —CONHR4 or —COR4, and each of R1, R2 and R4, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, or a compound of formula (II) wherein each of Y2 and Y3, which may be the same or different, is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, —SO2R9, —CO2R9, —CONHR9 or —COR9, Z is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclyl, —CH?C(NHR10)CH((CH2)mCO2R11)(C?O)CH3 or —CH2(C?O)CH((CH2)mCO2R11)(C?O)CH3, R8 is —(CH2)nCO2R12, each of R5 to R7 and R9 to R12, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, and each of m and n, which may be the same or different, is 1 to 6 or a compound of formula (III) wherein each of Y4 to Y6, which may be the same or

Abstract: A method of identifying an agent which modulates hydroxylation of hypoxia inducible factor (HIF), comprises contacting a HIF asparagine hydroxylase and a test substance in the presence of a substrate of the hydroxylase under conditions in which asparagine in the substrate is hydroxylated in the absence of the test substance; and determining hydroxylation of the substrate. Preferably the substrate is a HIF polypeptide comprising HIF-1?, a fragment thereof comprising Asn 803 of HIF-1? or a peptide analogue of HIF-1? or fragment thereof comprising an asparagine equivalent to Asn 803 of HIF-1? and wherein hydroxylation of Asn 803 or of a said equivalent asparagine is determined.

Abstract: The invention provides a compound of one of the formulae (A), (B), (C), (D), (E), (F) as herein defined, or a salt thereof, for use in the treatment of a condition associated with increased or decreased HIF levels or activity, or a condition in which an increase or decrease in HIF levels or activity may be beneficial.

Abstract: A method for detecting 2-oxoglutarate oxygenase activity, which method comprises: (i) contacting a 2-oxoglutarate oxygenase and a substrate of the 2-oxoglutarate oxygenase in the presence of 2-oxoglutarate; (ii) adding a derivatisation reagent capable of forming a fluorescent product with 2-oxoglutarate; (iii) detecting the fluorescent product produced by the reaction between the derivatisation reagent and 2-oxoglutarate, if any, thereby detecting 2-oxoglutarate oxgenase activity.

Abstract: A process for the preparation of a substituted C-2 ?-lactam comprises incubating a 2-substituted 3-aminocarboxylic acid with a ?-lactam synthetase under conditions such that the 2-substituted 3-aminocarboxylic acid is cyclised to produce a substituted C-2 ?-lactam. The process can be used to produce an antibiotic or ?-lactamase inhibitor.

Abstract: A process for preparing clavulanic acid and other clavam derivatives using an enzyme system from Streptomyces, particularly S. Clavuligerus.