Abstract: The present invention relates to methods and means for detecting and/or quantifying lactate. Specifically, the present invention is directed to a method for detecting and/or quantifying lactate in a sample comprising the steps of: a) providing an electrode comprising a lactate dehydrogenase (LDH) comprising a flavin mononucleotide (FMN) and an amino acid sequence of SEQ ID NO: 2, or an amino acid sequence having at least 50% sequence identity to SEQ ID NO: 2, comprising the following sequence T-(Xx)n1-F-(Xx)n2-X1-X2-(Xx)n3-X3-X4 (SEQ ID NO: 1), wherein T is T122 of SEQ ID NO: 2, or corresponding to T122, F is F152 of SEQ ID NO: 2, or corresponding to F152, Xx is any amino acid, n1 is an integer of 25 to 35, n2 is an integer of 40 to 45, n3 is an integer of 5 to 20, X1 is N or F, X2 is L or F, X3 is G, T, or S, and X4 is I or V; b) contacting the sample with the electrode; and c) detecting the oxidation of lactate by the LDH, wherein the oxidation of lactate is performed in the presence of a redox mediator.

Abstract: 1. A vehicle system for controlling operation of a vehicle includes one or more processing circuits configured to set a pre-calibrated value of a steering input device of the vehicle as a center value, the steering input device configured to receive an input from an operator to steer one or more tractive elements of the vehicle, monitor a precheck condition regarding an operational characteristic of the vehicle associated with a straight-line travel of the vehicle, control, in response to the precheck condition not being satisfied for a threshold time, an operation of the vehicle, and update, in response to the precheck condition being satisfied for the threshold time, the center value to be a current steering position value of the steering input device.

Abstract: The present invention is directed to compositions and methods of treating or preventing diseases or disorders with inhibitors of SHP2, alone, and in combination with other therapeutic agents such as RAS pathway inhibitors (e.g., MEK inhibitors); methods of establishing appropriate treatment plans for subjects based upon the expression of one or more biomarker indicative of SHP2 inhibitor sensitivity; and methods of determining sensitivity to a SHP2 inhibitor based on a phosphorylation status of SHP2.

Abstract: An apparatus for repairing a test-contact arrangement includes: a movable arm at whose end effector at least one heat-conductive receptacle is formed, at which a heat-absorption surface is formed; a control device configured for controlling a movement of the arm; a heating device configured for heating the heat-absorption surface; and a temperature measuring device configured for measuring a radiation temperature of a solder material of the solder connection. The receptacle is configured for receiving at least one heat-conductive blade element, and the control device is configured for moving the blade element via a movement of the arm in relation to the test-contact arrangement to sever the at least one solder connection so that at least one solder bridge to be repaired is removable.

Abstract: A device for handling a test contact in which the device includes a contact head provided with a test contact receptacle at its contact end, the test contact receptacle having a positioning unit having at least two, preferably three, positioning surfaces for coming into positioning contact with a test contact and for positioning the test contact relative to the contact end of the contact head. The at least one positioning surface of the positioning unit being formed as a base contact surface and at least one more positioning surface of the positioning unit being formed as an edge contact surface. Furthermore, a manufacturing system is also provided for manufacturing a test contact arrangement for testing semiconductor components.

Abstract: A recombinant flavocytochrome b2 (FCb2), comprising a mature FCb2 peptide sequence of a native FCb2, or a functionally active variant of said mature FCb2 peptide sequence, wherein the N-terminus of said mature FCb2 peptide sequence consists of a truncated signal peptide sequence replacing the native signal peptide sequence, and wherein said truncated signal peptide sequence is of the following structure from N- to C-terminus: i. a methionine; ii. optionally a tag sequence; iii. an amino acid sequence of a length of 0-9 amino acids of the native signal peptide sequence, corresponding to the amino acid sequence up to 9 amino acids directly upstream of the I/L/V-x-N/A/L motif of the native signal peptide sequence of FCb2; and iv. the I/L/V-x-N/A/L motif, which can be of number 0, 1, or can be partially truncated, wherein if the number is 0 or the I/L/V-x-N/A/L is partially truncated, the length of the amino acid sequence of iii.

Abstract: A train station has at least one transportation route for traffic of vehicles, wherein the at least one transportation route is provided with a vehicle tunnel. At least one public waiting area is arranged adjacent to the at least one transportation route. An enclosure is provided in which the at least one public waiting area is arranged, wherein the enclosure has at least one side wall. At least one ambient air purification arrangement for purifying ambient air is provided that has one or more filter units for separating solid, liquid or gaseous ambient air pollutants from the ambient air. The one or more filter units are arranged at and/or in the at least one side wall of the enclosure.

Abstract: A system allows a user to create new designs for apparel and preview these designs before manufacture. Software and lasers are used in finishing apparel to produce a desired wear pattern or other design. As the user designs apparel, the system provides feedback as to what designs can be used, such as avoiding technical constraints with their designs.

Abstract: A filter device for ambient air filtration has a blower housing with air inlet and air outlet. A device for generating an air flow is arranged in the blower housing and generates an air flow in operation from air inlet to air outlet. A flexible air conducting hose is provided with a first open end connected to the air outlet of the blower housing and with a second closed end. The flexible air conducting hose has openings arranged between first open end and second closed end. Filter elements are arranged in the openings, respectively. The filter elements separate a raw side inside the air conducting hose from a clean side downstream of the filter element. The air conducting hose is inflated in operation of the device by the air flow. The flexible air conducting hose has a reduced air permeability compared to the air permeability of the filter elements.

Abstract: A system for detecting a sub-surface defect comprising a transducer fluidly coupled to a part located in a tank containing a liquid configured to transmit ultrasonic energy, the transducer configured to scan the part to create scan data of the scanned part; a pulser/receiver coupled to the transducer configured to receive and transmit the scan data; a processor coupled to the pulser/receiver, the processor configured to communicate with the pulser/receiver and collect the scan data; and the processor configured to detect the sub-surface defect and the processor configured to have a sub-surface defect confidence assessment and a prioritization for further human evaluation.

Abstract: The present invention is directed to compositions and methods of treating or preventing diseases or disorders with inhibitors of SHP2, alone, and in combination with other therapeutic agents such as RAS pathway inhibitors (e.g., MEK inhibitors); methods of establishing appropriate treatment plans for subjects based upon the expression of one or more biomarker indicative of SHP2 inhibitor sensitivity; and methods of determining sensitivity to a SHP2 inhibitor based on a phosphorylation status of SHP2.

Abstract: A 3-Dimensional golf game having a horizontal surface, a vertical surface, and a curvilinear surface that interconnects the horizontal and vertical surfaces, wherein at least the vertical surface includes one or more ball-receiving cups. The game of skill is played by one or more players putting or striking a golf ball along the horizontal surface with sufficient force to travel through the curvilinear surface and up the vertical surface. The force of gravity then causes the ball to return back down the vertical surface and—if appropriately aimed and struck—the ball travels downwardly into the opening of the least one ball receiving cup. Players are awarded points for successfully landing the ball into the ball receiving cup and the game may include differently sized and/or positioned cups having different point values.

Abstract: A 3-Dimensional golf game having a horizontal surface, a vertical surface, and a curvilinear surface that interconnects the horizontal and vertical surfaces, wherein at least the vertical surface includes one or more ball-receiving cups. The game of skill is played by one or more players putting or striking a golf ball along the horizontal surface with sufficient force to travel through the curvilinear surface and up the vertical surface. The force of gravity then causes the ball to return back down the vertical surface and—if appropriately aimed and struck—the ball travels downwardly into the opening of the least one ball receiving cup. Players are awarded points for successfully landing the ball into the ball receiving cup and the game may include differently sized and/or positioned cups having different point values.

Abstract: An ambient air purification device has a filter device arranged in a filter receiving region of its housing. The filter device has a main filter element and a prefilter element, each having a circumferential frame device. A clamping force generating device is provided in the housing to exert an axial clamping force on the frame device of the main filter element resting, when mounted, at the frame device of the prefilter element. The clamping force is transmitted to the frame device of the prefilter element and presses the latter seal-tightly via a seal against a circumferential contact shoulder of the filter receiving region to seal the filter device in the filter receiving region. The frame device of the main filter element is sealed indirectly by the frame device of the prefilter element in relation to the housing and has no seal location of its own in relation to the housing.

Abstract: A circuit for controlling electrical power is described herein. In accordance with one embodiment, the circuit comprises: a circuit node operably connected to a pass element configured to be switched on and off in accordance with a drive signal applied at the circuit node; a communication interface configured to receive data from an external controller operably connected to the communication interface; and a control circuit configured to generate, in a first mode of operation, the drive signal dependent on parameters of a first parameter set and based on data received via the communication interface, and to generate, in a second mode of operation, the drive signal dependent on parameters of a second parameter set while discarding data received via the communication interface.

Abstract: An ambient air purifying device has a blower housing with air inlet and air outlet. In the blower housing, a flow generating device is arranged generating an air flow from air inlet to air outlet. Between air inlet and air outlet, a filter device is arranged with filter elements arranged relative to each other in a V shape. The blower housing has a servicing door through which the blower housing interior is accessible. The filter device has a filter element support held at the blower housing and supporting the filter elements. The filter element support is pivotably supported about an axis at the blower housing. The filter element support is transferrable from an operating state, in which it is completely inside the blower housing, into a servicing state, in which it projects at least partially through the servicing door from the blower housing, by pivoting about the axis.

Abstract: A 3-Dimensional golf game having a horizontal surface, a vertical surface, and a curvilinear surface that interconnects the horizontal and vertical surfaces, wherein at least the vertical surface includes one or more ball-receiving cups. The game of skill is played by one or more players putting or striking a golf ball along the horizontal surface with sufficient force to travel through the curvilinear surface and up the vertical surface. The force of gravity then causes the ball to return back down the vertical surface and—if appropriately aimed and struck—the ball travels downwardly into the opening of the least one ball receiving cup. Players are awarded points for successfully landing the ball into the ball receiving cup and the game may include differently sized and/or positioned cups having different point values.

Abstract: A road vehicle with a vehicle frame and a rear axle connected to the vehicle frame is provided with an ambient air purification device with filter elements for removing dust, particulate matter, and gases from ambient air. The ambient air purification device is arranged transverse to a longitudinal vehicle axis in an exterior region of the road vehicle at a vehicle rear of the road vehicle in an underfloor region such that at least the filter elements are arranged behind the rear axle of the road vehicle in a travel direction of the road vehicle. The ambient air purification device is received in an installation space of the vehicle frame. The ambient air purification device is flowed through in longitudinal vehicle direction. A free outflow zone of the ambient air purification device is arranged, in travel direction of the road vehicle, behind the ambient air purification device.

Abstract: The present invention is directed to compositions and methods of treating or preventing diseases or disorders with inhibitors of SHP2, alone, and in combination with other therapeutic agents such as RAS pathway inhibitors (e.g., MEK inhibitors); methods of establishing appropriate treatment plans for subjects based upon the expression of one or more biomarker indicative of SHP2 inhibitor sensitivity; and methods of determining sensitivity to a SHP2 inhibitor based on a phosphorylation status of SHP2.