Abstract: A modified U7 snRNA construct comprising at least one antisense sequence having between 16 to 30 nucleotides which are at least 90% complementary to a splicing element of a TDP-43 regulated cryptic exon sequence or flanking regions thereof and wherein the U7 snRNA construct is capable of modulating splicing of the TDP-43 regulated cryptic exon in a cell. The splicing element may be selected from a splice site, a TDP-43 binding region, or an exonic splice enhancer. Vectors and pharmaceutical compositions comprising the construct are also described, as well as constructs for use in the treatment of diseases associated with TDP-43 dysfunction. Example TDP-43 regulated cryptic exon sequences include TDP-43 regulated cryptic exons in UNC13A, STMN2 and INSR genes.

Abstract: A modified U7 snRNA construct, more particularly a U7 smOPT construct, is described having (i) an antisense sequence having between 16 to 30 nucleotides which is at least 90% complementary to a TDP-43 regulated cryptic exon sequence or flanking regions thereof, and (ii) a sequence comprising a binding domain for a hnRNP protein, wherein the construct is capable of modulating splicing of the TDP-43 regulated cryptic exon in a cell. Vectors and pharmaceutical compositions comprising the construct are also described, as well as constructs for use in the treatment of diseases associated with TDP-43 dysfunction. Example TDP-43 regulated cryptic exon sequences include TDP-43 regulated cryptic exons in UNC13A, STMN2 and INSR genes.

Abstract: A system includes a first sensor system and a second sensor system. The first sensor system includes a first internal clock, a first sensor configured to generate data describing an environment, and a Universal Serial Bus (USB) module. The second sensor system includes a second internal clock and a controller configured to perform a precision time protocol (PTP) to synchronize the second internal clock with the first internal clock. The precision time protocol includes transmitting timestamped messages encoded in USB bulk messages between the first sensor system and the second sensor system. The timestamped messages may be encoded in USB musical instrument digital interface (MIDI) bulk messages.

Abstract: Described herein are microRNA expression systems, and/or microRNA cloning systems. Described herein are also methods of expressing microRNAs or guide sequences against target mRNA, methods of producing said microRNA cloning systems and methods of knocking down target polynucleotides, such as mRNA.

Abstract: A wake-up radio system in a wireless sensor network, the wake-up radio comprising: an analog front end configured to communicate with matching network; an analog to digital converter coupled to the analog front end; and a digital baseband coupled to the analog to digital converter, wherein the digital baseband outputs a fast wake-up signal and a secure wake-up signal, and wherein the wake-up radio listens to all channels simultaneously.

Abstract: A system includes a first sensor system and a second sensor system. The first sensor system includes a first internal clock, a first sensor configured to generate data describing an environment, and a Universal Serial Bus (USB) module. The second sensor system includes a second internal clock and a controller configured to perform a precision time protocol (PTP) to synchronize the second internal clock with the first internal clock. The precision time protocol includes transmitting timestamped messages encoded in USB bulk messages between the first sensor system and the second sensor system. The timestamped messages may be encoded in USB musical instrument digital interface (MIDI) bulk messages.

Abstract: Described herein are methods for treating a subject having or at risk of developing a disorder affecting the central nervous system (CNS) (e.g., a neurocognitive disorder, a neuromuscular disorder, or a neurodegenerative disorder (such as FTD, AD, PD, dementia with Lewy bodies, ALS, or a related neurocognitive or motor neuron disorder) or a lysosomal storage disorder). The methods of the disclosure may include administering an adeno-associated viral (AAV) vector that expresses a therapeutic protein (e.g., whose deficiency or lack of activity is associated with the disorder or whose supplementation is likely to benefit the patient). The AAV vectors of the disclosure may be administered, e.g., in particular quantities and by way of particular routes of administration that achieve gene expression in the CNS while avoiding transduction in peripheral tissues (e.g., liver, lung, and spleen).

Abstract: A wake-up radio system in a wireless sensor network, the wake-up radio comprising: an analog front end configured to communicate with matching network; an analog to digital converter coupled to the analog front end; and a digital baseband coupled to the analog to digital converter, wherein the digital baseband outputs a fast wake-up signal and a secure wake-up signal, and wherein the wake-up radio listens to all channels simultaneously.

Abstract: Disclosed are compositions comprising cellular constructs comprising mesenchymal cells and epithelial cells. Also disclosed are methods of making the cellular constructs, methods of hair restoration, and kits. The invention also discloses parallel bio-printing systems and methods for making cellular constructs, such as cellular constructs comprising mesenchymal cells and epithelial cells.

Abstract: Disclosed are compositions comprising cellular constructs comprising mesenchymal cells and epithelial cells. Also disclosed are methods of making the cellular constructs, methods of hair restoration, and kits. The invention also discloses parallel bio-printing systems and methods for making cellular constructs, such as cellular constructs comprising mesenchymal cells and epithelial cells.

Abstract: A wake-up radio system in a wireless sensor network, the wake-up radio comprising: an analog front end configured to communicate with matching network; an analog to digital converter coupled to the analog front end; and a digital baseband coupled to the analog to digital converter, wherein the digital baseband outputs a fast wake-up signal and a secure wake-up signal, and wherein the wake-up radio listens to all channels simultaneously.

Abstract: A wake-up radio system in a wireless sensor network, the wake-up radio comprising: an analog front end configured to communicate with matching network; an analog to digital converter coupled to the analog front end; and a digital baseband coupled to the analog to digital converter, wherein the digital baseband outputs a fast wake-up signal and a secure wake-up signal, and wherein the wake-up radio listens to all channels simultaneously.

Abstract: The invention to which this application relates is to a propeller of the type for use in relation to water vessels and which can be moved between an in-use position in which the blades of the propeller extend outwardly to provide a propulsion force when rotated and, a storage position in which the desire is to minimize the effect of the blades as the vessel moves through the water and in which the blades are held substantially in line with the body of the propeller. The location means which allow the blades to be connected to the body are located within the body and thereby minimize the risk of corrosion and thereby increase the life of the propeller whilst also providing a secure fitment of the blades to the body and allowing ease of movement of the blades between in-use and storage positions.

Abstract: A wake-up radio system in a wireless sensor network, the wake-up radio comprising: an analog front end configured to communicate with matching network; an analog to digital converter coupled to the analog front end; and a digital baseband coupled to the analog to digital converter, wherein the digital baseband outputs a fast wake-up signal and a secure wake-up signal, and wherein the wake-up radio listens to all channels simultaneously.

Abstract: The invention relates to a drive system, and method of forming the same, for a craft in water, said drive system comprising a drive means, one or more shafts which are provided in connection with the drive means via one or more gear assemblies and at least one of said shafts having a free end with location means to allow the same to be located with a propeller of the said craft to impart rotational drive to the propeller. The location means are at least partially located within a port in the body of the propeller and intermediate said location means and the walls of the said port there is provided a substantially non-conductive deformable material sleeve which separates the propeller body from the said shaft and retains the propeller body in drive engagement with the location means.

Abstract: The invention relates to a drive system, and method of forming the same, for a craft in water, said drive system comprising a drive means, one or more shafts which are provided in connection with the drive means via one or more gear assemblies and at least one of said shafts having a free end with location means to allow the same to be located with a propeller of the said craft to impart rotational drive to the propeller. The location means are at least partially located within a port in the body of the propeller and intermediate said location means and the walls of the said port there is provided a substantially non-conductive deformable material sleeve which separates the propeller body from the said shaft and retains the propeller body in drive engagement with the location means.

Abstract: The invention to which this application relates is to a propeller of the type, which is typically, although not necessary exclusively, for use in relation to vessels for use in water and, most typically, propellers of a type which can be moved between an in-use position in which the blades of the propeller extend outwardly to provide a propulsion force when rotated and, a storage position in which the desire is to minimise the effect of the blades as the vessel moves through the water and in which the blades are held substantially in line with the body of the propeller. The location means which allow the blades to be connected to the body are located within the body and thereby minimise the risk of corrosion and thereby increase the life of the propeller whilst also providing a secure fitment of the blades to the body and allowing ease of movement of the blades between in-use and storage positions.

Abstract: Apparatus suitable for use in positioning ceiling or wall panels in predetermined locations. The apparatus includes one or more channel means shaped to receive at least part of a panel in use, said channel means at least partially defined by one or more substantially planar outer walls and at least one inner wall. At least part of the inner wall depends away from the outer wall thereby forming the opening into said channel means through which the ceiling or wall panel is inserted in use.

Abstract: Disclosed are compositions comprising cellular constructs comprising mesenchymal cells and epithelial cells. Also disclosed are methods of making the cellular constructs, methods of hair restoration, and kits. The invention also discloses parallel bio-printing systems and methods for making cellular constructs, such as cellular constructs comprising mesenchymal cells and epithelial cells.

Abstract: Embodiments of the present invention are directed to ingredients, formulations, methods of manufacture and use of an oral rehydration solution (“ORS”) in the prevention and treatment of dehydration in humans. More specifically, invention embodiments relate to flavored electrolyte drink mixtures that relieve the dehydrating effects caused by travel, exercise, over-indulgence of toxic substances, and various illnesses in individual subjects. An ORS embodiment of the present invention restores fluid and electrolyte balance in humans as fast and as effectively as IV therapy, and thereby reduces the incidence of dehydration in human populations as well as rehydrating individuals in circumstances where IV therapy is not practical or wanted.