Patents by Inventor Christopher Silk

Christopher Silk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sequencing methods using enzyme conformation
    Patent number: 8911972
    Abstract: Systems and methods are provided for single-molecule sequencing of template nucleic acids in which the signal from a label attached to a polymerase enzyme is used to monitor conformational changes in the polymerase which occur while labeled nucleotides or nucleotide analogs are added to a growing nucleic acid chain which is complementary to the template nucleic acid. The signal indicative of the conformational state of the enzyme is used to determine with higher confidence when true nucleotide or nucleotide analog incorporation events occur, allowing for the improved quality of base calls and sequence determination.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: December 16, 2014
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Mark Chaisson, Sonya Clark, Christopher Silk, John Lyle, Lei Jia, Keith Bjornson
  • SEQUENCING METHODS USING ENZYME CONFORMATION
    Publication number: 20110160077
    Abstract: Systems and methods are provided for single-molecule sequencing of template nucleic acids in which the signal from a label attached to a polymerase enzyme is used to monitor conformational changes in the polymerase which occur while labeled nucleotides or nucleotide analogs are added to a growing nucleic acid chain which is complementary to the template nucleic acid. The signal indicative of the conformational state of the enzyme is used to determine with higher confidence when true nucleotide or nucleotide analog incorporation events occur, allowing for the improved quality of base calls and sequence determination.
    Type: Application
    Filed: December 14, 2010
    Publication date: June 30, 2011
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Mark Chaisson, Sonya Clark, Christopher Silk, John Lyle, Lei Jia, Keith Bjornson