Patents by Inventor Christopher Sims
Christopher Sims has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11955966Abstract: An analog input device including at least one mounting panel and a matrix of analog push button assemblies mounted thereon. Each analog push button assembly including an analog pressure sensor including a pressure reception arrangement having an optical sensing sub-arrangement configured to measure an amount of light varied according to a pressure sensed at the pressure reception arrangement and an output terminal for outputting an analog signal corresponding to the amount of light measured, and a plunger element configured to exert the pressure on the pressure reception arrangement. The analog input device may include a multiplexer including an input side coupled to the push button assemblies and an output side; an analog-to-digital converter coupled to the output side of the multiplexer; a processor coupled to the analog-to-digital converter and configured to output a data packet; and a communication interface configured to transmit the data packet to a host computing device.Type: GrantFiled: August 23, 2022Date of Patent: April 9, 2024Assignee: Razer (Asia-Pacific) Pte. Ltd.Inventors: Chung Wei Lee, Thuan Teck Tan, Wenliang Yang, Alvin Sim, Kok Kiong Low, Ling Duan, Christopher Mitchell
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Publication number: 20240026270Abstract: The present invention is directed to a method of making a live cell construct or a support, comprising: (a) providing a non-cellular organic polymer support having a top surface, a bottom surface, and an intermediate portion there between, and (b) contacting a cross-linking agent to one surface of said support for a time sufficient to generate a gradient of cross-linking of said polymer in said intermediate portion. Also provided are live cell constructs, supports, and methods of use of the supports and live cell constructs.Type: ApplicationFiled: July 11, 2023Publication date: January 25, 2024Inventors: Nancy Allbritton, Yuli Wang, Hennayaka Mudiyanselage Dulan Gunasekara, Christopher Sims
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Patent number: 11566213Abstract: A microfabricated device having at least one gas-entrapping feature formed therein in a configuration that entraps air bubbles upon wetting the feature with a solvent or solution is described. The device includes a sacrificial residue in contact with the gas-entrapping feature, the dissolution of which guides the wetting of the gas-entrapping feature.Type: GrantFiled: July 29, 2019Date of Patent: January 31, 2023Assignee: The University of North Carolina at Chapel HillInventors: Nancy L. Allbritton, Yuli Wang, Christopher Sims
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Publication number: 20220288452Abstract: Aspects are directed to visual support for exercise compliance including capturing, via a camera of a user device, images of a first person performing one or more motions. Previously recorded images of a second person performing the one or more motions are accessed via the user device. Combined images are created by overlaying the images of the first person performing the one or more motions on the images of the second person performing the one or more motions. The combined images are output via a display device.Type: ApplicationFiled: August 13, 2020Publication date: September 15, 2022Inventors: Christopher Sims, Christopher Bignell
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Patent number: 11193110Abstract: A method of making a live cell construct is carried out by: (a) providing a non-cellular support having a top surface and a bottom surface, (b) contacting live undifferentiated cells to the non-cellular support, and then (c) propagating a gastrointestinal epithelial cell monolayer on said top surface. In some embodiments, the live cells in the monolayer include: (i) undifferentiated cells (e.g., stem or progenitor cells); and (ii) optionally, but in some embodiments preferably, differentiated cells (e.g., enterocytes, Paneth cells, enteroendocrine cells, tuft cells, microcells, intra-epithelial lymphocytes, and/or goblet cells). Constructs formed by such methods and methods of using the same (e.g., in high through-put screening) are also described.Type: GrantFiled: January 29, 2016Date of Patent: December 7, 2021Assignee: The University of North Carolina at Chapel HillInventors: Nancy Allbritton, Yuli Wang, Christopher Sims, Scott Magness, Scott Bultman
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Patent number: 11046926Abstract: An apparatus for collecting or culturing cells or cell colonies includes: a common substrate formed from a flexible resilient polymeric material and having a plurality of wells formed therein; and a plurality of rigid cell carriers releasably connected to said common substrate, with said carriers arranged in the form of an array, and with each of the carriers resiliently received in one of the wells. A method of collecting or culturing cells or cell colonies with such an apparatus is carried out by depositing a liquid media carrying cells on the apparatus so that said cells settle on or adhere to said the carriers; and then (c) releasing at least one selected carrier having said cells thereon by gradual application of release energy to each carrier from the cavity in which it is received (e.g., by pushing with a probe).Type: GrantFiled: April 4, 2018Date of Patent: June 29, 2021Assignee: The University of North Carolina at Chapel HillInventors: Nancy Allbritton, Christopher Sims, Yuli Wang, Pavak Kirit Shah
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Publication number: 20200231917Abstract: A microfabricated device having at least one gas-entrapping feature formed therein in a configuration that entraps air bubbles upon wetting the feature with a solvent or solution is described. The device includes a sacrificial residue in contact with the gas-entrapping feature, the dissolution of which guides the wetting of the gas-entrapping feature.Type: ApplicationFiled: July 29, 2019Publication date: July 23, 2020Inventors: Nancy L. Allbritton, Yuli Wang, Christopher Sims
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Patent number: 10364411Abstract: A microfabricated device having at least one gas-entrapping feature formed therein in a configuration that entraps air bubbles upon wetting the feature with a solvent or solution is described. The device includes a sacrificial residue in contact with the gas-entrapping feature, the dissolution of which guides the wetting of the gas-entrapping feature.Type: GrantFiled: June 1, 2018Date of Patent: July 30, 2019Assignee: The University of North Carolina at Chapel HillInventors: Nancy Allbritton, Yuli Wang, Christopher Sims
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Publication number: 20180346860Abstract: A microfabricated device having at least one gas-entrapping feature formed therein in a configuration that entraps air bubbles upon wetting the feature with a solvent or solution is described. The device includes a sacrificial residue in contact with the gas-entrapping feature, the dissolution of which guides the wetting of the gas-entrapping feature.Type: ApplicationFiled: June 1, 2018Publication date: December 6, 2018Inventors: Nancy Allbritton, Yuli Wang, Christopher Sims
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Publication number: 20180223237Abstract: An apparatus for collecting or culturing cells or cell colonies includes: a common substrate formed from a flexible resilient polymeric material and having a plurality of wells formed therein; and a plurality of rigid cell carriers releasably connected to said common substrate, with said carriers arranged in the form of an array, and with each of the carriers resiliently received in one of the wells. A method of collecting or culturing cells or cell colonies with such an apparatus is carried out by depositing a liquid media carrying cells on the apparatus so that said cells settle on or adhere to said the carriers; and then (c) releasing at least one selected carrier having said cells thereon by gradual application of release energy to each carrier from the cavity in which it is received (e.g., by pushing with a probe).Type: ApplicationFiled: April 4, 2018Publication date: August 9, 2018Inventors: Nancy Allbritton, Christopher Sims, Yuli Wang, Pavak Kirit Shah
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Patent number: 9994805Abstract: A microfabricated device having at least one gas-entrapping feature formed therein in a configuration that entraps air bubbles upon wetting the feature with a solvent or solution is described. The device includes a sacrificial residue in contact with the gas-entrapping feature, the dissolution of which guides the wetting of the gas-entrapping feature.Type: GrantFiled: May 31, 2013Date of Patent: June 12, 2018Assignee: The University of North Carolina at Chapel HillInventors: Nancy Allbritton, Yuli Wang, Christopher Sims
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Patent number: 9963666Abstract: An apparatus for collecting or culturing cells or cell colonies includes: a common substrate formed from a flexible resilient polymeric material and having a plurality of wells formed therein; and a plurality of rigid cell carriers releasably connected to said common substrate, with said carriers arranged in the form of an array, and with each of the carriers resiliently received in one of the wells. A method of collecting or culturing cells or cell colonies with such an apparatus is carried out by depositing a liquid media carrying cells on the apparatus so that said cells settle on or adhere to said the carriers; and then (c) releasing at least one selected carrier having said cells thereon by gradual application of release energy to each carrier from the cavity in which it is received (e.g., by pushing with a probe).Type: GrantFiled: May 18, 2015Date of Patent: May 8, 2018Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILLInventors: Nancy Allbritton, Christopher Sims, Yuli Wang, Pavak Kirit Shah
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Publication number: 20180002672Abstract: A method of making a live cell construct is carried out by: (a) providing a non-cellular support having a top surface and a bottom surface, (b) contacting live undifferentiated cells to the non-cellular support, and then (c) propagating a gastrointestinal epithelial cell monolayer on said top surface. In some embodiments, the live cells in the monolayer include: (i) undifferentiated cells (e.g., stem or progenitor cells); and (ii) optionally, but in some embodiments preferably, differentiated cells (e.g., enterocytes, Paneth cells, enteroendocrine cells, tuft cells, microcells, intra-epithelial lymphocytes, and/or goblet cells). Constructs formed by such methods and methods of using the same (e.g., in high through-put screening) are also described.Type: ApplicationFiled: January 29, 2016Publication date: January 4, 2018Inventors: Nancy Allbritton, Yuli Wang, Christopher Sims, Scott Magness, Scott Bultman
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Patent number: 9765291Abstract: An apparatus for collecting or culturing cells or cell colonies includes: a common substrate formed from a flexible resilient polymeric material and having a plurality of wells formed therein; and a plurality of rigid cell carriers releasably connected to said common substrate, with said carriers arranged in the form of an array, and with each of the carriers resiliently received in one of the wells. A method of collecting or culturing cells or cell colonies with such an apparatus is carried out by depositing a liquid media carrying cells on the apparatus so that said cells settle on or adhere to said the carriers; and then (c) releasing at least one selected carrier having said cells thereon by gradual application of release energy to each carrier from the cavity in which it is received (e.g., by pushing with a probe).Type: GrantFiled: May 18, 2015Date of Patent: September 19, 2017Assignee: The University of North Carolina at Chapel HillInventors: Nancy Allbritton, Christopher Sims, Yuli Wang, Pavak Kirit Shah
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Publication number: 20150259637Abstract: An apparatus for collecting or culturing cells or cell colonies includes: a common substrate formed from a flexible resilient polymeric material and having a plurality of wells formed therein; and a plurality of rigid cell carriers releasably connected to said common substrate, with said carriers arranged in the form of an array, and with each of the carriers resiliently received in one of the wells. A method of collecting or culturing cells or cell colonies with such an apparatus is carried out by depositing a liquid media carrying cells on the apparatus so that said cells settle on or adhere to said the carriers; and then (c) releasing at least one selected carrier having said cells thereon by gradual application of release energy to each carrier from the cavity in which it is received (e.g., by pushing with a probe).Type: ApplicationFiled: May 18, 2015Publication date: September 17, 2015Inventors: Nancy Allbritton, Christopher Sims, Yuli Wang, Pavak Kirit Shah
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Publication number: 20150251151Abstract: An apparatus for collecting or culturing cells or cell colonies includes: a common substrate formed from a flexible resilient polymeric material and having a plurality of wells formed therein; and a plurality of rigid cell carriers releasably connected to said common substrate, with said carriers arranged in the form of an array, and with each of the carriers resiliently received in one of the wells. A method of collecting or culturing cells or cell colonies with such an apparatus is carried out by depositing a liquid media carrying cells on the apparatus so that said cells settle on or adhere to said the carriers; and then (c) releasing at least one selected carrier having said cells thereon by gradual application of release energy to each carrier from the cavity in which it is received (e.g., by pushing with a probe).Type: ApplicationFiled: May 18, 2015Publication date: September 10, 2015Inventors: Nancy Allbritton, Christopher Sims, Yuli Wang, Pavak Kirit Shah
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Publication number: 20150210972Abstract: A microfabricated device having at least one gas-entrapping feature formed therein in a configuration that entraps air bubbles upon wetting the feature with a solvent or solution is described. The device includes a sacrificial residue in contact with the gas-entrapping feature, the dissolution of which guides the wetting of the gas-entrapping feature.Type: ApplicationFiled: May 31, 2013Publication date: July 30, 2015Applicant: The University of North Carolina at Chapel HillInventors: Nancy Allbritton, Yuli Wang, Christopher Sims
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Patent number: 9068155Abstract: An apparatus for collecting or culturing cells or cell colonies includes: a common substrate formed from a flexible resilient polymeric material and having a plurality of wells formed therein; and a plurality of rigid cell carriers releasably connected to said common substrate, with said carriers arranged in the form of an array, and with each of the carriers resiliently received in one of the wells. A method of collecting or culturing cells or cell colonies with such an apparatus is carried out by depositing a liquid media carrying cells on the apparatus so that said cells settle on or adhere to said the carriers; and then (c) releasing at least one selected carrier having said cells thereon by gradual application of release energy to each carrier from the cavity in which it is received (e.g., by pushing with a probe).Type: GrantFiled: June 1, 2012Date of Patent: June 30, 2015Assignee: The University of North Carolina at Chapel HillInventors: Nancy Allbritton, Christopher Sims, Yuli Wang, Pavak Kirit Shah
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Publication number: 20150012562Abstract: A literary recommendation engine is used to receive an object of interest to a user and make a recommendation based on the received object. For example, a user may provide a name of a book or author and receive a list of recommendations that a services determines to be responsive to the user's interests based on a profile for the “seed” book (or author) and/or the user profile.Type: ApplicationFiled: February 4, 2014Publication date: January 8, 2015Applicant: Zola Books Inc.Inventors: Patrick Hu, Ardeshir Khazaei, Christopher Sim, Karen Ye Sun
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Publication number: 20130065795Abstract: An apparatus for collecting or culturing cells or cell colonies includes: a common substrate formed from a flexible resilient polymeric material and having a plurality of wells formed therein; and a plurality of rigid cell carriers releasably connected to said common substrate, with said carriers arranged in the form of an array, and with each of the carriers resiliently received in one of the wells. A method of collecting or culturing cells or cell colonies with such an apparatus is carried out by depositing a liquid media carrying cells on the apparatus so that said cells settle on or adhere to said the carriers; and then (c) releasing at least one selected carrier having said cells thereon by gradual application of release energy to each carrier from the cavity in which it is received (e.g., by pushing with a probe).Type: ApplicationFiled: June 1, 2012Publication date: March 14, 2013Inventors: Nancy Allbritton, Christopher Sims, Yuli Wang, Pavak Kirit Shah